Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Donald F. Weaver"'
Autor:
Christopher J. Barden, Fan Wu, J. Pedro Fernandez-Murray, Erhu Lu, Shengguo Sun, Marcia M. Taylor, Annette L. Rushton, Jason Williams, Mahtab Tavasoli, Autumn Meek, Alla Siva Reddy, Lisa M. Doyle, Irina Sagamanova, Kovilpitchai Sivamuthuraman, Robert T. M. Boudreau, David M. Byers, Donald F. Weaver, Christopher R. McMaster
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention. Here, computer-aided drug design is use
Externí odkaz:
https://doaj.org/article/d68ded4d00cb4c5f9f17aa749d95ef6c
Autor:
John Muscedere, MD, David M. Maslove, MD, MS, Christopher J. Barden, PhD, Donald F. Weaver, MD, PhD, J. Gordon Boyd, MD, PhD, Stephanie Sibley, MD, MS, Tracy Boyd, Oleksa Rewa, MD, MSc, Martin Albert, Marios Roussos, MD, MPH, Patrick A. Norman, MSc, Andrew G. Day, MSc, for the Canadian Critical Care Trials Group
Publikováno v:
Critical Care Explorations, Vol 6, Iss 2, p e1045 (2024)
OBJECTIVES:. Respiratory failure secondary to COVID-19 is associated with morbidity and mortality. Current anti-inflammatory therapies are effective but are given systemically and have significant side effects. Furosemide has anti-inflammatory proper
Externí odkaz:
https://doaj.org/article/75bfeef1c7a44b88adb6c1fa800a9118
Autor:
Donald F. Weaver
Publikováno v:
Brain Sciences, Vol 14, Iss 1, p 41 (2023)
One of the major obstacles confronting the formulation of a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity—a complexity that traverses the full structural and phenomenological spectrum, including molecular, macro
Externí odkaz:
https://doaj.org/article/2c30cdf7d41b49659bcd5f251990c620
Autor:
Myongin Oh, Donald F. Weaver
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The human brain is a dynamic multiplex of information, both neural (neurotransmitter-to-neuron, involving 1.5×1015 action potentials per minute) and immunological (cytokine-to-microglia, providing continuous immune surveillance via 1.5×1010 immunoc
Externí odkaz:
https://doaj.org/article/d0c6e7cd6b0a4219a1cda275123f943b
Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression
Publikováno v:
Brain Sciences, Vol 13, Iss 6, p 852 (2023)
Neuroimmune-triggered neuroinflammation of the central nervous system is emerging as an important aetiopathogenic factor for multiple neurological disorders, including depression, dementia, Alzheimer’s disease, multiple sclerosis and others. Trypto
Externí odkaz:
https://doaj.org/article/af456c0cbff2491d871f9cf0a0278d32
Autor:
Karl Savonije, Donald F. Weaver
Publikováno v:
Brain Sciences, Vol 13, Iss 2, p 292 (2023)
The need to identify new potentially druggable biochemical mechanisms for Alzheimer’s disease (AD) is an ongoing priority. The therapeutic limitations of amyloid-based approaches are further motivating this search. Amino acid metabolism, particular
Externí odkaz:
https://doaj.org/article/e1463ac5217341c6aae4e82d9dd5826e
Autor:
Felix S. Meier‐Stephenson, Vanessa C. Meier‐Stephenson, Michael D. Carter, Autumn R. Meek, Yanfei Wang, Luzhe Pan, Qiangwei Chen, Sheila Jacobo, Fan Wu, Erhu Lu, Gordon A. Simms, Laural Fisher, Alaina J. McGrath, Virgil Fermo, Christopher J. Barden, Harman D.S. Clair, Todd N. Galloway, Arun Yadav, Valérie Campágna‐Slater, Mark Hadden, Mark Reed, Marcia Taylor, Brendan Kelly, Elena Diez‐Cecilia, Igri Kolaj, Clarissa Santos, Imindu Liyanage, Braden Sweeting, Paul Stafford, Robert Boudreau, G. Andrew Reid, Ryan S. Noyce, Leanne Stevens, Agnieszka Staniszewski, Hong Zhang, Mamidanna R. V. S. Murty, Pascale Lemaire, Solenne Chardonnet, Christopher D. Richardson, Valérie Gabelica, Edwin DePauw, Richard Brown, Sultan Darvesh, Ottavio Arancio, Donald F. Weaver
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in concurrent, interdependent immunopathic and proteopathic path
Externí odkaz:
https://doaj.org/article/1e2d8b504a1f482e94ad2f6036b37c9c
Autor:
Zhiyu Wang, Yanfei Wang, Prachi Vilekar, Seung-Pil Yang, Mayuri Gupta, Myong In Oh, Autumn Meek, Lisa Doyle, Laura Villar, Anja Brennecke, Imindu Liyanage, Mark Reed, Christopher Barden, Donald F. Weaver
Publikováno v:
PeerJ, Vol 8, p e9533 (2020)
The novel coronavirus SARS-CoV-2 has become a global health concern. The morbidity and mortality of the potentially lethal infection caused by this virus arise from the initial viral infection and the subsequent host inflammatory response. The latter
Externí odkaz:
https://doaj.org/article/d693a7d171bf48fd9f935c5c836eac85
Autor:
Donald F. Weaver
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract A molecular level conceptualization of the pathogenesis of Alzheimer's disease (AD) remains elusive with many competing hypotheses, particularly via proteopathic and immunopathic mechanisms. However, these need not be competitive. If amyloid
Externí odkaz:
https://doaj.org/article/09cad2c76dd74e8d9d25e99d4dd4ab67
Autor:
Kurt R. Stover, Stellar Lim, Terri-Lin Zhou, Paul M. Stafford, Jonathan Chow, Haoyuan Li, Nila Sivanenthiran, Sivakami Mylvaganam, Chiping Wu, Donald F. Weaver, James Eubanks, Liang Zhang
Publikováno v:
IBRO Reports, Vol 3, Iss C, Pp 33-44 (2017)
The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated
Externí odkaz:
https://doaj.org/article/c2f5c86ad8ac45fa942ed56c54012e67