Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Donald F. M. Stevenson"'
Autor:
Valerie May, Jeremy J. Lambert, David K. Gemmell, Alison Anderson, Maurice S. Maidment, Alexander C. Campbell, David R. Hill, Donald F. M. Stevenson, Claire Hill-Venning, David Rees, Richard J. Marshall, Andrew C. Boyd, Alan Byford, Hardy Sundaram, John A. Peters, Niall M. Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 40:1668-1681
(3 alpha,5 alpha)-3-Hydroxypregnan-20-ones and (3 alpha,5 alpha)-3-hydroxypregnane-11,20-diones bearing a 2 beta-morpholinyl substituent were synthesized, and the utility of these steroids as anesthetic agents was evaluated through determination of t
Autor:
Jeremy J. Lambert, McPhail P, John A. Peters, Sansbury Fh, Muntoni A, Hutchinson Ej, Bennett Dj, Donald F. M. Stevenson, Maurice S. Maidment, Alison Anderson, Feilden H, Miller S, Ross McGuire, Cooke A, Delia Belelli, Buchanan Ki, Casula A, Sundaram H, Gemmell Dk, Hamilton Nm
Publikováno v:
Journal of medicinal chemistry. 44(22)
In the search for a novel water-soluble general anesthetic agent the activity of an alpha-amino acid phenolic ester lead, identified from patent literature, was markedly improved. In addition to improving in vivo activity in mice, good in vitro activ
Autor:
Donald F. M. Stevenson, Colin L. Hewett, Robert Thomas Logan, George Mcgarry, James Cairns, Gilbert F. Woods
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1558-1564
The sequential reaction of 3β-acetoxypregna-5,16-dien-20-one (1) with methylmagnesium bromide and then methyl iodide has been examined in detail. The major product (85%) was 3β-hydroxy-16α,17α-dimethylpregn-5-en-20-one (2). Other products identif
Autor:
Robert Thomas Logan, Gilbert F. Woods, James Cairns, Donald F. M. Stevenson, George Mcgarry, Robert Gibson Roy
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2306-2316
The development of a 21-alkylation reaction which proceeds via the lithium 20(21)-enolate is described and its scope demonstrated by the preparation of a variety of 21-alkylpregnane derivatives. Application of this process to 11β-acetoxy-16α,17α-d
Autor:
John H. Pick, Gilbert F. Woods, Maurice S. Maidment, Donald F. M. Stevenson, Alexander C. Campbell
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :163-171
17,17-Dimethyl-18-nor-5β-androsta-8,11,13-trien-3α-yl acetate (6) has been prepared from 9α,11α-epoxy-17α-methyl-5β-androstane-3α,17β-diol 3-acetate (5) in good yield. An attempt to repeat the aromatisation with the analogous 9α,11α-epoxy-5
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1567
Two new routes to pulvinones have been developed, one of which involves a novel Wittig reaction. For the first time, members of the E-series, including the parent (E)-pulvinone, are reported and the structural elucidation of the geometric isomers is