Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donald F. Hora"'
Autor:
David Wilson, Bindhu V. Karanam, Mona Purcell, Maria Madeira, Gary G. Chicchi, Jianming Bao, Liza Gantert, Robert J. DeVita, Huagang Lu, Wai-Si Eng, Sander G. Mills, Richard G. Ball, Andrew J. Kassick, Peter Lin, Sanjeev Kumar, Jaime Lynn Bunda, George A. Doss, Kwei-Lan C. Tsao, Jacquelyn J. Cook, Xinchun Tong, Richard Tschirret-Guth, Jinlong Jiang, Koppara Samuel, Richard Hargreaves, Hong Wang, Donald F. Hora
Publikováno v:
Journal of Medicinal Chemistry. 56:5940-5948
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba
Autor:
Steven B. Heymsfield, Amy O. Johnson-Levonas, Susan Nicolich, Alison M. Strack, Tung M. Fong, Joana Achanfuo-Yeboah, Donald Thompson, P Cunningham, G. J. Hickey, Donald F. Hora, Terry D. Faidley
Publikováno v:
Metabolism. 61:546-553
Pharmacologic inhibition of the cannabinoid-1 receptor (CB1R) in rodent models leads to weight loss and time-dependent changes in energy balance. This study evaluated the effects of CB1R inhibition on weight loss, energy expenditure (EE), and food in
Autor:
Kenneth Alves, Thomas S. Reger, Kelly M. Treonze, Susan Nicolich, Patricia Kellerhouse, Salony Maniar, Paul A. Fischer, Donald W. Nicholson, Jasmine Zunic, Russell B. Lingham, Donald F. Hora, Peppi Prasit, Nicholas D. Smith, Richard A. Mumford, Keith Judd, Alison A. Kulick, Donald Thompson, Qian Si, William K. Hagmann, Benito Munoz, Ken Vakerich
Publikováno v:
Veterinary Immunology and Immunopathology. 130:79-87
The purpose of this study was to characterize the alpha(4)beta(1) receptor (CD49d/CD29, very late antigen-4, VLA-4) on circulating equine leukocytes and to evaluate the intrinsic potency of an alpha(4)beta(1) receptor antagonist (Compound B) in the h
Autor:
Sloan Stribling, Donald F. Thompson, Junying Wang, Xinchun Tong, Lauren P. Shearman, Cathy C. R.-R. Huang, Joana Achanfuo-Yeboah, Susan Nicolich, Andrea Frassetto, Tung M. Fong, Donald F. Hora, Chun-Pyn Shen, Nancy N. Tsou, Alison M. Strack, Richard G. Ball, Julie Lao, Gerard J. Hickey, Terry D. Faidley, Jeffrey J. Hale, Joan M. Fletcher, William K. Hagmann, Petr Vachal, Richard Z. Chen, Jing Chen Xiao
Publikováno v:
Journal of Medicinal Chemistry. 52:2550-2558
A novel series of 1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists was discovered through high throughput screening (HTS) and medicinal chemistry lead optimization. Potency and in vivo properties were systemati
Autor:
Donald F. Hora, Suzanne L. Ciccotto, James R. Reed, Stella H. Vincent, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Ralph A. Stearns, Maria G. Beconi, Charles S. Elmore, Yohannes Teffera, Yuan-Qing Xia
Publikováno v:
Drug Metabolism and Disposition. 35:525-532
The pharmacokinetics, metabolism, and excretion of sitagliptin [MK-0431; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine], a potent dipeptidyl peptidase 4 inhibitor, were eva
Autor:
Christopher J. Kochansky, Donald F. Hora, Sui Wang, Stella H. Vincent, K Lynn, Zhen Wang, J Brunner, Mi-Sook Kim, Zhongzhou Shen, Ronald B. Franklin
Publikováno v:
Xenobiotica. 34:665-674
1. The metabolism and pharmacokinetics of two structurally similar PPAR agonists, MRL-I, (2R)-7-[3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy]-2-ethyl-3,4-dihydro-2H-benzopyran-2-carboxylic acid, and MRL-II, (2R)-7-[3-[2-chloro-4-(2,2,2,-trifluoroe
Autor:
Roy G. Smith, P Cunningham, Eric L. Rickes, D. Zhang, G. J. Hickey, C. H. Chang, Donald F. Hora, Terry D. Faidley, C. Li, Lesley Mcnamara, Susan Nicolich, T. J. McDonald, Drisko J
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. 222:70-77
The activity of the growth hormone secretagog, L-163,255, on growth hormone (GH), growth hormone-releasing factor (GRF), and somatostatin (SRIF) levels was evaluated in a porcine model of hypophyseal portal blood (HPB) collection. Young, castrated pi
Autor:
Susan Nicolich, Terry D. Faidley, Donald F. Hora, T. Abribat, D. Zhang, Eric L. Rickes, C. H. Chang, Roy G. Smith, Lesley Mcnamara, J. E. Drisko, G. J. Hickey
Publikováno v:
Experimental Biology and Medicine. 217:188-196
A method of collecting hypophyseal portal blood (HPB) in conscious pigs was used to show the relationship between GRF and somatostatin (SRIF) concentration and peripheral GH response. Six male castrate pigs (approximately 63 kg body weight) had HPB a
Autor:
Richard L. Lieber, Denise B. Cuizon, Donald F. Hora, Ravi P. Nargund, Randall L. Mohler, David H. Gershuni, Thomas M. Jacks, William P. Feeney, Klaus D. Schleim, Michelle L. Haven, Michael A. Lopez, Gerard J. Hickey
Publikováno v:
Journal of Orthopaedic Research. 15:519-527
Twenty-two beagles were divided into two equal groups, and the right hindlimb of each animal was immobilized at 105 degrees of knee flexion by external fixation. After 10 weeks of fixation, the device was removed, allowing free mobility for the follo
Autor:
Andrew J, Kassick, Jinlong, Jiang, Jaime, Bunda, David, Wilson, Jianming, Bao, Huagang, Lu, Peter, Lin, Richard G, Ball, George A, Doss, Xinchun, Tong, Kwei-Lan C, Tsao, Hong, Wang, Gary, Chicchi, Bindhu, Karanam, Richard, Tschirret-Guth, Koppara, Samuel, Donald F, Hora, Sanjeev, Kumar, Maria, Madeira, Waisi, Eng, Richard, Hargreaves, Mona, Purcell, Liza, Gantert, Jacquelyn, Cook, Robert J, DeVita, Sander G, Mills
Publikováno v:
Journal of medicinal chemistry. 56(14)
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba