Zobrazeno 1 - 10
of 442
pro vyhledávání: '"Donald F, Hunt"'
Autor:
Xu Huang, Rodolfo Zentella, Jeongmoo Park, Larry Reser, Dina L. Bai, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Tai-ping Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DELLA proteins are conserved master growth regulators that play a central role in controlling plant development in response to internal and environmental cues. DELLAs function as transcription regulators, which are recruited to target promot
Externí odkaz:
https://doaj.org/article/d4b402e6ea0c4bd589f53ff346977a2d
Autor:
Benjamin M. Lorton, Christopher Warren, Humaira Ilyas, Prithviraj Nandigrami, Subray Hegde, Sean Cahill, Stephanie M. Lehman, Jeffrey Shabanowitz, Donald F. Hunt, Andras Fiser, David Cowburn, David Shechter
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109458- (2024)
Summary: Histone chaperones–structurally diverse, non-catalytic proteins enriched with acidic intrinsically disordered regions (IDRs)–protect histones from spurious nucleic acid interactions and guide their deposition into and out of nucleosomes.
Externí odkaz:
https://doaj.org/article/308a4f46ac144de8bb1576a4e9c88faf
Autor:
Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausió
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
ABSTRACTAn immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions undergone during differentiation, with special
Externí odkaz:
https://doaj.org/article/54a5cb1d65414b17924e9dea1aa45c9f
Autor:
Shivesh Kumar, Yan Wang, Ye Zhou, Lucas Dillard, Fay-Wei Li, Carly A. Sciandra, Ning Sui, Rodolfo Zentella, Emily Zahn, Jeffrey Shabanowitz, Donald F. Hunt, Mario J. Borgnia, Alberto Bartesaghi, Tai-ping Sun, Pei Zhou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that reg
Externí odkaz:
https://doaj.org/article/a852133c77164e09acf70749474a4f8e
Autor:
Maxim I. Maron, Stephanie M. Lehman, Sitaram Gayatri, Joseph D. DeAngelo, Subray Hegde, Benjamin M. Lorton, Yan Sun, Dina L. Bai, Simone Sidoli, Varun Gupta, Matthew R. Marunde, James R. Bone, Zu-Wen Sun, Mark T. Bedford, Jeffrey Shabanowitz, Hongshan Chen, Donald F. Hunt, David Shechter
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102971- (2021)
Summary: Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To determine the cellular consequences of type I (Rme2a) and II (Rme2s) P
Externí odkaz:
https://doaj.org/article/c804eaefab6848b4b721da294a0ebcd5
Autor:
Sarah A. Penny, Jennifer G. Abelin, Stacy A. Malaker, Paisley T. Myers, Abu Z. Saeed, Lora G. Steadman, Dina L. Bai, Stephen T. Ward, Jeffrey Shabanowitz, Donald F. Hunt, Mark Cobbold
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
There is a pressing need for novel immunotherapeutic targets in colorectal cancer (CRC). Cytotoxic T cell infiltration is well established as a key prognostic indicator in CRC, and it is known that these tumor infiltrating lymphocytes (TILs) target a
Externí odkaz:
https://doaj.org/article/c061e36b679342809afb621a520a51ca
Autor:
Brandon A. Kemp, Nancy L. Howell, John J. Gildea, Josh D. Hinkle, Jeffrey Shabanowitz, Donald F. Hunt, Mark R. Conaway, Susanna R. Keller, Robert M. Carey
Publikováno v:
Circulation Research. 132:1127-1140
Background: Extracellular renal interstitial guanosine cyclic 3’,5’-monophosphate (cGMP) inhibits renal proximal tubule (RPT) sodium (Na + ) reabsorption via Src (Src family kinase) activation. Through which target extracellular cGMP acts to indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cc45e96c54d2b952f325ba0e65f6698
https://doi.org/10.1161/circresaha.122.321693
https://doi.org/10.1161/circresaha.122.321693
Autor:
Mark E Smolkin, Gina R Petroni, Kimberly A Chianese-bullock, Kelly T Smith, Geoffrey Weiss, Nico Buettner, Mark Cobbold, Jeffrey Shabanowitz, Nikole Varhegyi, Elizabeth Gaughan, Victor H Engelhard, Rebecca C Obeng, Kara L Cummings, Angela L Ambakhutwala, Amanda Lulu, Paisley Myers, Keira E Mahoney, Emily H Hall, Kathleen Haden, Donald F Hunt, Craig L Slingluff, Jr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Phosphorylated peptides presented by MHC molecules represent a new class of neoantigens expressed on cancer cells and recognized by CD8 T-cells. These peptides are promising targets for cancer immunotherapy. Previous work identified an HLA
Externí odkaz:
https://doaj.org/article/2f1ba13970c949eeb55d8d1382a456e4
Autor:
Rebecca Pavlos, Elizabeth J. McKinnon, David A. Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Ryan Schutte, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Thomas Kaever, Paisley Myers, Ellen Speers, Stacy A. Malaker, Jeffrey Shabanowitz, Yuan Jing, Silvana Gaudieri, Donald F. Hunt, Mary Carrington, David W. Haas, Simon Mallal, Elizabeth J. Phillips
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediat
Externí odkaz:
https://doaj.org/article/713379e67e8e4c309dc4c182e4231712
Autor:
Mark Cobbold, Donald F. Hunt, Jeffrey Shabanowitz, Dina L. Bai, Manoj Raghavan, Justin C. Loke, Paisley T. Myers, Lora G. Steadman, Sarah A. Penny, Stacy A. Malaker
Table S1. Summary of samples used for this study. Table S2. Antibodies used in the study. Figure S1. Mass spectra of all peptides referenced in figures 2 and 3. Figure S2. ETD Mass spectrum of RPPItQSSL containing an asymmetrically dimethylated Arg r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fbf197129358e9555e813e2db890e2
https://doi.org/10.1158/2326-6066.22537801.v1
https://doi.org/10.1158/2326-6066.22537801.v1
