Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Donald E. Thornton"'
Autor:
Patricia E. Cole, Michael A. Carducci, Merrill S. Kies, Roy S. Herbst, Donald E. Thornton, Vikram Sinha, Rana Sullivan, Luna Musib, Jill Schmidt, Jeanne R. Riddle, Roberto Pili, Julie R. Brahmer, Mylene T. Truong, Nathan Enas
Publikováno v:
Journal of Clinical Oncology. 24:4092-4099
Purpose This phase I study was conducted to determine the recommended dose of enzastaurin, an oral protein kinase C beta (PKCβ) inhibitor, for phase II trials. Secondary objectives were maximum-tolerated dose (MTD), pharmacokinetics (PK), toxicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5345e17e3dbebeea79e6f43e9fc907
https://doi.org/10.1200/jco.2005.05.3447
https://doi.org/10.1200/jco.2005.05.3447
Autor:
Eric K. Rowinsky, Patrick J. Loehrer, Charles D. Blanke, Joel Picus, Donald E. Thornton, William John, Jeffery W. Clark, Lawrence N. Schulman
Publikováno v:
Cancer. 88:1807-1813
BACKGROUND The aim of this study was to confirm the activity and assess the safety profile of multitargeted antifolate (MTA) for patients with metastatic colorectal adenocarcinoma. METHODS Forty-six patients were enrolled in the study, 35 with colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc69c82db0cae55c826e96b6e891acee
https://doi.org/10.1002/(sici)1097-0142(20000415)88:8<1807::aid-cncr8>3.0.co
https://doi.org/10.1002/(sici)1097-0142(20000415)88:8<1807::aid-cncr8>3.0.co
Autor:
Indrajati Kohar, David G. Cornwell, Donald E. Thornton, Laura E. Lantry, Peter T. Southwell-Keely, Zongcheng Jiang, Kenneth H. Jones
Publikováno v:
Lipids. 33:295-301
Cytotoxicities of tocopherols (alpha-T, gamma-T, delta-t), their para (alpha-TQ, gamma-TQ, delta-TQ)- and ortho (Tocored)-quinone oxidation products, the synthetic quinone analog of gamma-TQ containing a methyl group substituted for the phytyl side-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f9c8f27c5738560201f206de8f6689
https://doi.org/10.1007/s11745-998-0208-8
https://doi.org/10.1007/s11745-998-0208-8
Publikováno v:
Cancer Treatment Reviews. 21:185-198
Despite nearly five decades of investigating numerous agents and regimens, there is no curative cytotoxic chemotherapy for advanced, metastatic, breast cancer. Total response rates of 45-80% and complete response rates of 5-25% can be achieved, but m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a80947b110e1275435f472fff8cc4b
https://doi.org/10.1016/0305-7372(95)90000-4
https://doi.org/10.1016/0305-7372(95)90000-4
Autor:
Chuan Shih, Donald E. Thornton
Publikováno v:
Antifolate Drugs in Cancer Therapy ISBN: 9781475745214
Since the early 1950s, extensive research efforts have been devoted to the discovery and development of antifolate antimetabolites as chemotherapeutic agents for the management of neoplastic diseases. However, it was only in the last 10–15 yr, beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6759189885352826ed527959218828c
https://doi.org/10.1007/978-1-59259-725-3_8
https://doi.org/10.1007/978-1-59259-725-3_8
Autor:
Donald E. Thornton, Zongcheng Jiang, Guifen Liu, Hanfang Zhang, Kenneth H. Jones, David G. Cornwell
Publikováno v:
Free radical biologymedicine. 18(6)
We found previously that [d]-alpha-tocopherol (alpha-T) and [d]-gamma-tocopherol (gamma-T) are lipid antioxidants (thiobarbituric acid test) in model systems containing arachidonic acid (AA), cumene hydroperoxide, and Fe3+ and in smooth muscle cell (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6de906201f556b41873772265e121f
https://pubmed.ncbi.nlm.nih.gov/7628732
https://pubmed.ncbi.nlm.nih.gov/7628732
Publikováno v:
American journal of medical genetics. 41(4)
Multiple genes of hematopoietic importance have been localized to the long arm of chromosome 5 including granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukins (IL) 3, 4 and 5 to 5q23-31, colony stimulating factor 1 (CSF1) to 5q33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d584cff481c819e80952435fb1b37c40
https://pubmed.ncbi.nlm.nih.gov/1723247
https://pubmed.ncbi.nlm.nih.gov/1723247
Autor:
Earl N. Metz, Donald E. Thornton
Publikováno v:
Contemporary Internal Medicine ISBN: 9781475798258
A 32-year-old carpenter was in vigorous good health until about two months before his admission to the hospital when he began to be aware of increasing fatigue and some loss of appetite. A few weeks later, he developed shortness of breath with exerti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d85daca9d06e344af994ae5eed3097b
https://doi.org/10.1007/978-1-4757-9823-4_3
https://doi.org/10.1007/978-1-4757-9823-4_3
Publikováno v:
European Journal of Cancer. 33:S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26657027bb560dbaa158ebae75cffcf
https://doi.org/10.1016/s0959-8049(97)84450-4
https://doi.org/10.1016/s0959-8049(97)84450-4
Autor:
Donald E. Thornton, Alvie L. Davis, Anna M. Goebel, Criss C. Yakshe, Janet K. Swan, David R. Smith, Tommy J. McCord
Publikováno v:
Journal of Heterocyclic Chemistry. 16:1249-1252
Methyl 5-chloro- and 5,7-dichloro-2,1-benzisoxazole-3-carboxylates have been synthesized by treatment of o-nitromandelic and 5-chloro-2-nitroamandelic methyl esters, respectively, with thionyl chloride under appropriate reaction conditions. The struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fccabbf6d7c0031e21b204e3b8d0681b
https://doi.org/10.1002/jhet.5570160631
https://doi.org/10.1002/jhet.5570160631