Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Donald E. Bergstrom"'
Autor:
Jutta Wanner, Darlene Romashko, Douglas S Werner, Earl W May, Yue Peng, Ryan Schulz, Kenneth W Foreman, Suzanne Russo, Lee D Arnold, Maneesh Pingle, Donald E Bergstrom, Francis Barany, Stuart Thomson
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121793 (2015)
We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules. We synthesized two directed libraries of monomers, each comprised of a liga
Externí odkaz:
https://doaj.org/article/a96fd43cf1cf4560b2de89acf1760b8b
Autor:
Sarah F. Giardina, Douglas S. Werner, Maneesh Pingle, Philip B. Feinberg, Kenneth W. Foreman, Donald E. Bergstrom, Lee D. Arnold, Francis Barany
Publikováno v:
Journal of medicinal chemistry. 63(6)
β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e5070c5aa57547e015befeca85ada5
https://pubmed.ncbi.nlm.nih.gov/32057241
https://pubmed.ncbi.nlm.nih.gov/32057241
Autor:
Douglas S. Werner, Lee D. Arnold, Maneesh Pingle, Donald E. Bergstrom, Kenneth W. Foreman, Sarah F Giardina, Francis Barany
Publikováno v:
ACS Medicinal Chemistry Letters
Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d226169ab9fee6ac95d8f5adba737956
https://doi.org/10.1021/acsmedchemlett.8b00204
https://doi.org/10.1021/acsmedchemlett.8b00204
Autor:
Francis Barany, Lee D. Arnold, Douglas S. Werner, Donald E. Bergstrom, Sarah F Giardina, Maneesh Pingle
Publikováno v:
Pharmacology. 102:233-243
β-Tryptase is released from mast cells upon degranulation in response to allergic and inflammatory stimuli. Human tryptase is a homotetrameric serine protease with 4 identical active sites directed toward a central pore. These active sites present a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878744e5a1ce7c49808aa6f9fb976d86
https://doi.org/10.1159/000492078
https://doi.org/10.1159/000492078
Autor:
Eric L. Barker, Abbas Jarrahian, Vida Zohrabi-Kalantari, Caterina Bissantz, Donald E. Bergstrom, Andreas Link
Publikováno v:
Medicinal Chemistry. 9:881-888
Starting from cyclopentadiene, two racemic mixtures of 4-aminocyclopentane-1,3-diols were prepared in 8 steps and characterized. Structure determination proved the anticipated trans-orientation of the two oxygen atoms with respect to the plane of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b54b8457f1ddfa843786e6081e3625f
https://doi.org/10.2174/1573406411309060013
https://doi.org/10.2174/1573406411309060013
Publikováno v:
Archiv der Pharmazie. 345:677-686
Despite their simplicity, relatively few examples of 1,2,4 (1,3,4)-amino-, azido-, and hydroxy-substituted cyclopentanes are reported in the literature. We found that cyclopent-3-en-1-ol can be transformed into a significant variety of compounds of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b826e540bcdf204299eeec3ffdee830
https://doi.org/10.1002/ardp.201200101
https://doi.org/10.1002/ardp.201200101
Publikováno v:
Bioconjugate Chemistry. 21:1537-1544
We have synthesized a series of short, self-complementary oligonucleotide sequences modified at their 5'- and/or 3'- termini with a lipophilic dodecane (C12); these systems serve as models to assess the biophysical properties of double-stranded DNA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f3c752b7a99d6c7cfce2cdd12e480f
https://doi.org/10.1021/bc100201n
https://doi.org/10.1021/bc100201n
Autor:
Brian M. Laing, Alan M. Friedman, Donald E. Bergstrom, Ganesan Balasundarum, Maneesh Pingle, Pei-Sze Ng
Publikováno v:
Bioconjugate Chemistry. 21:1545-1553
A series of aliphatic and aromatic spacer molecules designed to cap the ends of DNA duplexes have been synthesized. The spacers were converted into dimethoxytrityl-protected phosphoramidites as synthons for oligonucleotides synthesis. The effect of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f469939ab6e447ed8891e6971578c464
https://doi.org/10.1021/bc100202y
https://doi.org/10.1021/bc100202y
Publikováno v:
Bioconjugate Chemistry. 19:592-597
( E)-5-[2-(Methoxycarbonyl)ethenyl]cytidine was biotinylated through a diisopropylsilylacetal linkage and attached to the surface of hydrophilic streptavidin-coated microspheres through the high-affinity noncovalent interaction between biotin and str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2f155bf7deed4134e0fbc0b73a5862
https://doi.org/10.1021/bc700336x
https://doi.org/10.1021/bc700336x
Publikováno v:
Birck and NCN Publications
We have developed novel fluorogenic transformations based on formation of CC bonds catalyzed by palladium using iodocoumarin 1 as a model aryl iodide, where fluorescence is quenched completely due to effects of the heavy, polarizable iodine atom. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950d91392d9fade995522635a0464522
https://doi.org/10.1002/adsc.200700384
https://doi.org/10.1002/adsc.200700384