Zobrazeno 1 - 10
of 591
pro vyhledávání: '"Donald E, Ingber"'
Autor:
Zohreh Izadifar, Justin Cotton, Siyu Chen, Viktor Horvath, Anna Stejskalova, Aakanksha Gulati, Nina T. LoGrande, Bogdan Budnik, Sanjid Shahriar, Erin R. Doherty, Yixuan Xie, Tania To, Sarah E. Gilpin, Adama M. Sesay, Girija Goyal, Carlito B. Lebrilla, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Modulation of the cervix by steroid hormones and commensal microbiome play a central role in the health of the female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate the human cervical epithelial-stroma
Externí odkaz:
https://doaj.org/article/0c123d582c57457d8c8042d389f2b87d
Autor:
Megan M Sperry, Berenice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski, Shanda Lightbown, Ramses Martinez, Susan Marquez, Joel Moore, Maria Plaza-Oliver, Adama M Sesay, Kostyantyn Shcherbina, Katherine Sheehan, Takako Takeda, Daniela Del Campo, Kristina Andrijauskaite, Exal Cisneros, Riley Lopez, Isabella Cano, Zachary Maxwell, Israel Jessop, Rafa Veraza, Leon Bunegin, Thomas J Percival, Jaclyn Yracheta, Jorge J Pena, Diandra M Wood, Zachary T Homas, Cody J Hinshaw, Jennifer Cox-Hinshaw, Olivia G Parry, Justin J Sleeter, Erik K Weitzel, Michael Levin, Michael Super, Richard Novak, Donald E Ingber
Publikováno v:
eLife, Vol 13 (2024)
Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially for organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screeni
Externí odkaz:
https://doaj.org/article/095738c148254bf3aca1f94a4c99d2bb
Autor:
Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K. Greene, Donald E. Ingber, Joyce Bischoff
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brain, and eyes. Patients may suffer from seizures, strokes, and glaucoma, and only symptomatic treatment is available. CM
Externí odkaz:
https://doaj.org/article/c5621ecbee9048b287dc17ebec595daa
Autor:
Jeong-Chan Lee, Su Yeong Kim, Jayeon Song, Hyowon Jang, Min Kim, Hanul Kim, Siyoung Q. Choi, Sunjoo Kim, Pawan Jolly, Taejoon Kang, Steve Park, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here,
Externí odkaz:
https://doaj.org/article/015a6a6345f84aa09864c957fcc97a30
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Human organs‐on‐chips (organ chips) are small microfluidic devices that allow human cells to perform complex organ‐level functions in vitro by recreating multi‐cellular and multi‐tissue structures and applying in vivo‐like biomec
Externí odkaz:
https://doaj.org/article/65071d66b6624c21a0c7ca48268af975
Autor:
Queeny Dasgupta, Amanda Jiang, Amy M. Wen, Robert J. Mannix, Yuncheng Man, Sean Hall, Emilia Javorsky, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Acute exposure to high-dose gamma radiation due to radiological disasters or cancer radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute pneumonitis and subsequent lung fibrosis. A microfluidic organ-on-a-c
Externí odkaz:
https://doaj.org/article/6ae3452b30aa4654a34caaf5a5e810af
Autor:
Sajjad Janfaza, Nandhinee Radha Shanmugam, Pawan Jolly, Prashanthi Kovur, Upasana Singh, Scott Mackay, David Wishart, Donald E. Ingber
Publikováno v:
Nanomaterials, Vol 14, Iss 9, p 796 (2024)
Continuous glucose monitoring is valuable for people with diabetes but faces limitations due to enzyme–electrode interactions and biofouling from biological samples that reduce sensor sensitivity and the monitoring performance. We created an enzyme
Externí odkaz:
https://doaj.org/article/aacb8688c00a491e804c84cb2c0f4e99
Autor:
Seongmin Kim, Arash Naziripour, Pranav Prabhala, Viktor Horváth, Abidemi Junaid, David T. Breault, Girija Goyal, Donald E. Ingber
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104921- (2024)
Summary: Background: Sulfadoxine-pyrimethamine (SP) antimalarial therapy has been suggested to potentially increase the birth weight of infants in pregnant women in sub-Saharan Africa, independently of malarial infection. Here, we utilized female int
Externí odkaz:
https://doaj.org/article/1052d97ecf594f1d99ffcccef20f927c
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
Externí odkaz:
https://doaj.org/article/8af1884ce4df43869295c061cce05605
Autor:
Gautam Mahajan, Erin Doherty, Tania To, Arlene Sutherland, Jennifer Grant, Abidemi Junaid, Aakanksha Gulati, Nina LoGrande, Zohreh Izadifar, Sanjay Sharma Timilsina, Viktor Horváth, Roberto Plebani, Michael France, Indriati Hood-Pishchany, Seth Rakoff-Nahoum, Douglas S. Kwon, Girija Goyal, Rachelle Prantil-Baun, Jacques Ravel, Donald E. Ingber
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and obstetric health, while the presence of diverse obligate or facultative anaerobic bacteria and a pa
Externí odkaz:
https://doaj.org/article/738d72b5adf94c56a245f3fe34145f30