Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Donald D. Raymond"'
Autor:
Lars E. Clark, Selma Mahmutovic, Donald D. Raymond, Taleen Dilanyan, Takaaki Koma, John T. Manning, Sundaresh Shankar, Silvana C. Levis, Ana M. Briggiler, Delia A. Enria, Kai W. Wucherpfennig, Slobodan Paessler, Jonathan Abraham
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Mach
Externí odkaz:
https://doaj.org/article/daef1e9d51b8461ba2ffa8c665295132
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Influenza virus and some other human pathogens evolve to evade herd immunity and, hence, to reinfect previously immune individuals. Individual humoral immune responses also evolve, through somatic mutation and selection in a process know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071ddcfbc906dc722d366951c5d5de76
http://europepmc.org/articles/PMC6936356
http://europepmc.org/articles/PMC6936356
Autor:
Shuyi Wang, Chengyan Zhao, Anya M. Bauer, Fang-Hua Lee, Cara W. Chao, Emily Lindemuth, Nicole A. Doria-Rose, Juliette Rando, Frederic Bibollet-Ruche, Kevin Wiehe, Mario Roederer, Chaim A. Schramm, Bette T. Korber, Donald D. Raymond, Kwan-Ki Hwang, Weimin Liu, George M. Shaw, Mark G. Lewis, Ronnie M. Russell, Hui Li, Stephen C. Harrison, Baoshan Zhang, Ryan S. Roark, Andrew G. Smith, Jesse Connell, Kevin O. Saunders, Hui Geng, Alexander I. Murphy, Mattia Bonsignori, Elena E. Giorgi, Maho Okumura, Hema Chug, Beatrice H. Hahn, John R. Mascola, Peter D. Kwong, Peter T. Hraber, Christina Rosario, Jessica G. Smith, David R. Ambrozak, Yu Ding, Wenge Ding, Richard Nguyen, Rosemarie D. Mason, Barton F. Haynes, Mark K. Louder, Daniel C. Douek, Kshitij Wagh, Jason Gorman, Bob C. Lin, Thomas B. Kepler, Wilton B. Williams, Neha Chohan, Garnett Kelsoe, Gwo-Yu Chuang, Julia DeVoto, Katharine J. Bar, M. Anthony Moody
Publikováno v:
Science
Convergent HIV evolution across species Human immunodeficiency virus (HIV) has a highly diverse envelope protein that it uses to target human cells, and the complexity of the viral envelope has stymied vaccine development. Roark et al. report that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed080ccce387e2255c23bd3823a0579
https://doi.org/10.1101/2020.08.05.237693
https://doi.org/10.1101/2020.08.05.237693
Autor:
Thomas C, Atack, Donald D, Raymond, Christa A, Blomquist, Charisse Flerida, Pasaje, Patrick R, McCarren, Jamie, Moroco, Henock B, Befekadu, Foxy P, Robinson, Debjani, Pal, Lisl Y, Esherick, Alessandra, Ianari, Jacquin C, Niles, William R, Sellers
Publikováno v:
ACS Medicinal Chemistry Letters
FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a905af3a1edf9948f554a164783d3d0d
https://pubmed.ncbi.nlm.nih.gov/33209191
https://pubmed.ncbi.nlm.nih.gov/33209191
Autor:
Stephen C. Harrison, Jack Ferdman, Ethan C. Settembre, M. Anthony Moody, Pirada Suphaphiphat, Aaron G. Schmidt, Donald D. Raymond, Goran Bajic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Antigenic variation requires frequent revision of annual influenza vaccines. Next-generation vaccine design strategies aim to elicit a broader immunity by directing the human immune response toward conserved sites on the principal viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b2b48aae65a727440e021024537288
https://doi.org/10.1073/pnas.1715471115
https://doi.org/10.1073/pnas.1715471115
Autor:
Khoi T. Do, Timothy M. Caradonna, Aaron G. Schmidt, Junhua Pan, Stephen C. Harrison, Nikolaus Grigorieff, Yuhang Liu, Donald D. Raymond, Simon Jenni
Publikováno v:
Journal of Molecular Biology. 429:1829-1839
Structure-based vaccine design depends on extensive structural analyses of antigen-antibody complexes.Single-particle electron cryomicroscopy (cryoEM) can circumvent some of the problems of x-ray crystallography as a pipeline for obtaining the requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c171e12b9c7b32e257246b3f531fa17
https://doi.org/10.1016/j.jmb.2017.05.011
https://doi.org/10.1016/j.jmb.2017.05.011
Autor:
Barton F. Haynes, Giuseppe Del Giudice, Oretta Finco, George Georgiou, Hua-Xin Liao, Khoi T. Do, Gregory C. Ippolito, Jack Ferdman, M. Anthony Moody, Pirada Suphaphiphat, Goran Bajic, Ethan C. Settembre, Stephen C. Harrison, Tae Hyun Kang, Michael J. Ernandes, Aaron G. Schmidt, Philip R. Dormitzer, Thomas B. Kepler, Shaun M Stewart, Donald D. Raymond, Jiwon Lee
Publikováno v:
Nature Medicine. 22:1465-1469
For broad protection against infection by viruses such as influenza or HIV, vaccines should elicit antibodies that bind conserved viral epitopes, such as the receptor-binding site (RBS). RBS-directed antibodies have been described for both HIV1–3 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c30047827aa8eea20bfe7d406f4170
https://doi.org/10.1038/nm.4223
https://doi.org/10.1038/nm.4223
Publikováno v:
Proceedings of the National Academy of Sciences. 109:19208-19213
Rift Valley fever and Toscana viruses are human pathogens for which no effective therapeutics exist. These and other phleboviruses have segmented negative-sense RNA genomes that are sequestered by a nucleocapsid protein (N) to form ribonucleoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c770281b06938aea1a6476e3275ab82c
https://doi.org/10.1073/pnas.1213553109
https://doi.org/10.1073/pnas.1213553109
Publikováno v:
Proceedings of the National Academy of Sciences. 107:11769-11774
Rift Valley fever virus (RVFV) is a negative-sense RNA virus (genus Phlebovirus , family Bunyaviridae ) that infects livestock and humans and is endemic to sub-Saharan Africa. Like all negative-sense viruses, the segmented RNA genome of RVFV is encap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0080ecaea412b5fa3a1064068e3eb058
https://doi.org/10.1073/pnas.1001760107
https://doi.org/10.1073/pnas.1001760107
Autor:
Kai W. Wucherpfennig, Ana M. Briggiler, Delia Enria, Lars Clark, Sundaresh Shankar, Silvana Levis, Takaaki Koma, Donald D. Raymond, Slobodan Paessler, Selma Mahmutovic, John T. Manning, Jonathan Abraham, Taleen Dilanyan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1e197fa9353822c6c1e2e4467b68c8
http://repo.lib.tokushima-u.ac.jp/112467
http://repo.lib.tokushima-u.ac.jp/112467