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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The classic guide to the undifferentiated patient–enhanced
Publikováno v:
Journal of the American College of Cardiology. 73:2743
Coronary artery subclavian steal syndrome has an incidence of 0.2-0.7%. First described in 1974 by Harjola and Valle, it results from >70% stenosis of the proximal subclavian artery, most commonly due to atherosclerotic disease. This results in lower
Publikováno v:
Developmental Biology. 331(1):89-98
Amphibian metamorphosis is accompanied by extensive intestinal remodeling. This process, mediated by thyroid hormone (TH) and its nuclear receptors, affects every cell type. Gut remodeling in Xenopus laevis involves epithelial and mesenchymal prolife
For more than forty years, the single-best guide for learning how to become a master clinical diagnostician Much more than a text describing how to perform a history and physical examination, DeGowin's Diagnostic Examination is unmatched in its abili
Publikováno v:
Developmental Biology. 304(1):260-271
Transgenic Xenopus laevis tadpoles that express a dominant negative form of the thyroid hormone receptor (TRDN) controlled by the cardiac actin muscle promoter (pCar) develop with very little limb muscle. Under the control of the tetracycline system
Autor:
Donald D. Brown
Publikováno v:
Thyroid. 15:815-821
Valerie Galton's prediction over 40 years ago that deiodinases would be important in amphibian metamorphosis has been confirmed. Expression of iodothyronine deiodinase type 2 (D2) and type 3 (D3) occurs in embryogenesis at relevant locations long bef
Publikováno v:
Proceedings of the National Academy of Sciences. 102:3720-3725
Thyroid hormone controls remodeling of the tadpole intestine during the climax of amphibian metamorphosis. In 8 days, the Xenopus laevis tadpole intestine shortens in length by 75%. Simultaneously, the longitudinal muscle fibers contract by about the
Autor:
Donald D. Brown
Publikováno v:
Journal of Biological Chemistry. 279:45291-45299
When I was asked to reflect as part of the celebration of the 100-year anniversary of the Journal of Biological Chemistry I recalled a talk by Seymour Cohen at the Federation meetings in Atlantic City about 1960. He began by thanking bacteriophage fo
Autor:
Donald D, Brown
Publikováno v:
Nature Medicine. 18:1496-1498
Publikováno v:
Proceedings of the National Academy of Sciences. 98:7348-7353
Two important features of amphibian metamorphosis are the sequential response of tissues to different concentrations of thyroid hormone (TH) and the development of the negative feedback loop between the pituitary and the thyroid gland that regulates