Výsledky vyhledávání - "Donald D Muccio"

Akademický článek

Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis.

Autor: Lizhi Wu, Sandeep C Chaudhary, Venkatram R Atigadda, Olga V Belyaeva, Steven R Harville, Craig A Elmets, Donald D Muccio, Mohammad Athar, Natalia Y Kedishvili

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153556 (2016)

UAB30 is an RXR selective agonist that has been shown to have potential cancer chemopreventive properties. Due to high efficacy and low toxicity, it is currently being evaluated in human Phase I clinical trials by the National Cancer Institute. While

Externí odkaz: https://doaj.org/article/09ed2b589b2e4e7abd2ce7f9805ba18f

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Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers

Autor: Venkatram R. Atigadda, Mahendra P. Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V. Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y. Kedishvili, Clinton J. Grubbs, Matthew B. Renfrow, Donald D. Muccio, Craig A. Elmets, Mohammad Athar

Publikováno v: J Med Chem

Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid toxicity from the anticancer activity of 1, we synthesized four new analogs of rexinoid 1, of whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b40461637cc0f417346b98efcc6e89d
https://doi.org/10.1021/acs.jmedchem.2c00735

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Supplementary Figure 1 from The CDK4/6 Inhibitor PD0332991 Reverses Epithelial Dysplasia Associated with Abnormal Activation of the Cyclin-CDK-Rb Pathway

Autor: Priscilla A. Furth, Donald D. Muccio, Clinton J. Grubbs, Michael J. Pishvaian, Bhaskar V.S. Kallakury, Edgar S. Díaz-Cruz, M. Carla Cabrera

PDF file - 643K, Relative expression levels of Cdk1, Rbl1 and Cdc25a in 4- and 7-month-old mice before and after TAg down-regulation by doxycycline treatment for 14 days and in conjunction with treatment with PD0332991 for 10 days, UAB30 for 14 days,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fab4c28919e1a5c101a4fde8c129ac
https://doi.org/10.1158/1940-6207.22525134

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Supplementary Figures 1 through 11 and Supplementary Figure Legends from Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma

Autor: Elizabeth A. Beierle, Clinton J. Grubbs, Donald D. Muccio, Elizabeth Mroczek-Musulman, Venkatram R. Atigadda, Jerry E. Stewart, Alicia M. Waters

Figure S1 / S2. UAB30 activated caspase 3. Figure S3. UAB30 increased nestin protein. Figure S4 / S5. UAB30 decreased neuroblastoma cellular proliferation. Figure S6 / S7. UAB30 did not alter expression or phosphorylation of ERK1/2 or AKT. Figure S8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eec685733995105952fb1722e984eab
https://doi.org/10.1158/1535-7163.22501552.v1

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Data from Preclinical Evaluation of a Novel RXR Agonist for the Treatment of Neuroblastoma

Autor: Elizabeth A. Beierle, Clinton J. Grubbs, Donald D. Muccio, Elizabeth Mroczek-Musulman, Venkatram R. Atigadda, Jerry E. Stewart, Alicia M. Waters

Neuroblastoma remains a common cause of pediatric cancer deaths, especially for children who present with advanced stage or recurrent disease. Currently, retinoic acid therapy is used as maintenance treatment to induce differentiation and reduce tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::348dc350f3894592ab83c27de40a958f
https://doi.org/10.1158/1535-7163.c.6536827.v1

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Data from The CDK4/6 Inhibitor PD0332991 Reverses Epithelial Dysplasia Associated with Abnormal Activation of the Cyclin-CDK-Rb Pathway

Autor: Priscilla A. Furth, Donald D. Muccio, Clinton J. Grubbs, Michael J. Pishvaian, Bhaskar V.S. Kallakury, Edgar S. Díaz-Cruz, M. Carla Cabrera

Loss of normal growth control is a hallmark of cancer progression. Therefore, understanding the early mechanisms of normal growth regulation and the changes that occur during preneoplasia may provide insights of both diagnostic and therapeutic import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0637b647844371086cfc433845fdc2
https://doi.org/10.1158/1940-6207.c.6544590

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Supplemental Figure 1: UAB30 increased nuclear expression of RXR. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

Autor: Elizabeth A. Beierle, Clinton J. Grubbs, Donald D. Muccio, Elizabeth Mroczek-Musulman, Venkatram R. Atigadda, Jerry E. Stewart, Alicia M. Waters

Representative photomicrographs of G401 cells stained for total RXR (red) and nucleus (DAPI, blue) showed increased overlap after UAB30 treatment (merged, bottom right panel) indicating increased RXR staining in the nucleus following UAB30 treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90e1c915e3151ca1804658caf4c5644
https://doi.org/10.1158/1535-7163.22508349.v1

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Supplemental Figure 3: UAB30 decreased proliferation. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

Autor: Elizabeth A. Beierle, Clinton J. Grubbs, Donald D. Muccio, Elizabeth Mroczek-Musulman, Venkatram R. Atigadda, Jerry E. Stewart, Alicia M. Waters

Cellular proliferation was measured with trypan blue exclusion. Cell lines were treated with UAB30 at 0 or 10 μM for 24 hrs. Cells were stained with trypan blue and counted with a hemacytometer. A The total number of cells decreased in all 3 cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b50f9f9e20fbcc372b8f6168f23d0b
https://doi.org/10.1158/1535-7163.22508343

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