Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Donald Chu"'
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766
https://doi.org/10.1021/acs.jmedchem.2c00766
Autor:
Xinkang Wang, Dietmar Seiffert, Kenneth P. Ellsworth, Mark D. Erion, Xueping Zhou, Patrick Andre, Amjad Ali, Gino Castriota, Scott D. Edmondson, Stan Kurowski, David E. Gutstein, Zhu Chen, Donald Chu, Weizhen Wu, Lin Chu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:476-483
Factor XI (FXI) is an integral component of the intrinsic pathway of the coagulation cascade and plays a critical role in thrombus formation. Because its role in the pathogenesis of cerebral microembolic signals (MES) is unclear, this study used a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb6f4efc77b882cdf123fcb2b15ca6a
https://doi.org/10.1124/jpet.116.238600
https://doi.org/10.1124/jpet.116.238600
Publikováno v:
Data in Brief, Vol 49, Iss , Pp 109434- (2023)
Data on the biotransfer of heavy metals along the soil-plant-edible insect-human food chain collected along a 60km pollution gradient is presented here. These datasets consists of concentrations of eight heavy metals (Arsenic, Cadmium, Copper, Chromi
Externí odkaz:
https://doaj.org/article/a97afe789fd245dbadcf6b763547a9e1
Autor:
Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala, Arielle Dorfman, Mary Atalla, Donald Chun, Veronica Viramontes, Christina Chang, Franziska Leifer, Patrick P. McDonald, David C. Cipolla
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Brensocatib is a novel, oral, selective, reversible inhibitor of dipeptidyl peptidase 1 (DPP1), which activates several neutrophil serine proteases (NSPs), including neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in the bone mar
Externí odkaz:
https://doaj.org/article/a26331d5dd3f4103b5293969b4ae00de
Autor:
Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Neutrophils have been implicated in initiating and perpetuating systemic lupus erythematosus and the resultant kidney damage in lupus nephritis (LN) patients, in part through an excessive release of neutrophil serine proteases (NSPs). NSP zymogens ar
Externí odkaz:
https://doaj.org/article/39068ea155094654afda96d63a8b6583
Autor:
Xinkang Wang, Dietmar Seiffert, Aimie M. Ogawa, Kim O’Neill, Xueping Zhou, Zhu Chen, Christopher M. Barbieri, David E. Gutstein, Weizhen Wu, Gino Castriota, Donald Chu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 360(3)
Coagulation Factor XII (FXII) plays a critical role in thrombosis. What is unclear is the level of enzyme occupancy of FXIIa that is needed for efficacy and the impact of FXIIa inhibition on cerebral embolism. A selective activated FXII (FXIIa) inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd024940e3436d99cf23b96edf33dfad
https://pubmed.ncbi.nlm.nih.gov/28035006
https://pubmed.ncbi.nlm.nih.gov/28035006
Publikováno v:
SPIE Proceedings.
The Geostationary Lightning Mappers (GLM) for the Geostationary Operational Environmental Satellite (GOES) GOES-R series will, for the first time, provide hemispherical lightning information 24 hours a day from longitudes of 75 and 137 degrees west.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2bce5499eae8dbb9586c1ce417e2e4
https://doi.org/10.1117/12.2242141
https://doi.org/10.1117/12.2242141
Publikováno v:
SPIE Proceedings.
The GOES-R magnetometer subsystem accuracy requirement is 1.7 nanoteslas (nT). During quiet times (100 nT), accuracy is defined as absolute mean plus 3 sigma. During storms (300 nT), accuracy is defined as absolute mean plus 2 sigma. Error comes both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::187ebfe7a16f5c9085c34caa32b89978
https://doi.org/10.1117/12.2228542
https://doi.org/10.1117/12.2228542
Autor:
Sivakumara K. Tadikonda, Monica Todirita, Melissa Dahya, Donald Chu, Delano R. Carter, Jeffrey Kronenwetter, Douglas C. Freesland
Publikováno v:
2016 ESA Workshop on Aerospace EMC (Aerospace EMC).
Time-varying spacecraft magnetic fields, i.e. stray fields, are a problem for magnetometer systems. While constant fields can be removed by calibration, stray fields are difficult to distinguish from ambient field variations. Putting two magnetometer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e090b704ff198ae2cf2a9f769b9552c1
https://doi.org/10.1109/aeroemc.2016.7504597
https://doi.org/10.1109/aeroemc.2016.7504597
Autor:
Aiwu Zhang, Ronald E. Painter, Stephen F. Previs, Shuo Quan, Heather Zhou, Adam B. Weinglass, Anka G. Ehrhardt, Daphne Szeto, Michael Kavana, Sheng-Ping Wang, Dan Xie, Marina Ichetovkin, Brian K. Hubbard, Larissa Wilsie, Karen O. Akinsanya, Thomas P. Roddy, Oksana C Palyha, Jing Xiao, Mark Rosenbach, Alison M. Strack, Donald Chu, Weihua Ni, Douglas Wisniewski, Douglas G. Johns, Jim Milligan, Paul A. Fischer, Sookhee Ha, Xi Ai, George H. Addona, Thomas F. Vogt, Gail Forrest, Jennifer Baysarowich
Publikováno v:
Biochemistry & Molecular Biology Journal.
Human genetics and pharmacologic clinical intervention demonstrate the key role of PCSK9 in cholesterol regulation. To understand the role of the C-terminal domain of PCSK9, two human mutations in this region (S462P and A522T PCSK9) have been profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80bb26633f7235181b008b1018ab1fa7
https://doi.org/10.21767/2471-8084.100026
https://doi.org/10.21767/2471-8084.100026