Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Donald C. Wilder"'
Autor:
Judith L. Treadway, David W. Piotrowski, R. Kirk McPherson, Jana Polivkova, Anne M. Brodeur, Shenping Liu, Bernard Hulin, David D. Boyer, Stephen J. Orena, Xiayang Qiu, Maria A. Vanvolkenburg, Dennis E. Danley, Donald C. Wilder, Janice C. Parker, Shawn D. Doran, Carolyn B. Soglia, Mark Ammirati, Kim M. Andrews
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1991-1995
A series of 4-substituted proline amides was synthesized and evaluated as inhibitors of dipeptidyl pepdidase IV for the treatment of type 2 diabetes. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb8cf65715687f0bc8ee1e7e04655a6
https://doi.org/10.1016/j.bmcl.2009.02.041
https://doi.org/10.1016/j.bmcl.2009.02.041
Autor:
Hong Wang, Judith L. Treadway, Maria A. Vanvolkenburg, Anne M. Brodeur, L. D. Mcclure, Shawn D. Doran, Jay S. Lillquist, Kim M. Andrews, Stephen J. Orena, Stephen W. Wright, Donald C. Wilder, Jana Polivkova, R. Kirk McPherson, Mark Ammirati, Janice C. Parker, Thanh V. Olson, Walter C. Soeller, Xiayang Qiu, Carolyn B. Soglia, Dennis E. Danley
Publikováno v:
Journal of Medicinal Chemistry. 49:3068-3076
Inhibitors of the glucagon-like peptide-1 (GLP-1) degrading enzyme dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes in animal models and in human subjects. A novel series of cis-2,5-dicyanopyrrolidine al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225566352cae2523ca6fd2fce0bf4d9
https://doi.org/10.1021/jm0600085
https://doi.org/10.1021/jm0600085