Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Donald C Sheppard"'
Autor:
François Le Mauff, Donald C. Sheppard
Publikováno v:
The Cell Surface, Vol 9, Iss , Pp 100095- (2023)
Half a century after their discovery, polymers of N-acetylgalactosamine produced by the Aspergilli have garnered new interest as mediators of fungal virulence. Recent work has focused on the Aspergillus fumigatus secreted and cell wall-associated het
Externí odkaz:
https://doaj.org/article/d748b189b3cf452a96e439981063d3d4
Autor:
Hong Liu, Jianfeng Lin, Quynh T. Phan, Fabrice N. Gravelat, Donald C. Sheppard, Scott G. Filler
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT During the initiation of invasive aspergillosis, inhaled Aspergillus fumigatus conidia are deposited on the epithelial cells lining the bronchi, terminal bronchioles, and alveoli. While the interactions of A. fumigatus with bronchial and typ
Externí odkaz:
https://doaj.org/article/ec3c38c7baaa4fb9b276cb2d53534c77
Autor:
Erum Razvi, Gregory B. Whitfield, Courtney Reichhardt, Julia E. Dreifus, Alexandra R. Willis, Oxana B. Gluscencova, Erin S. Gloag, Tarek S. Awad, Jacquelyn D. Rich, Daniel Passos da Silva, Whitney Bond, François Le Mauff, Donald C. Sheppard, Benjamin D. Hatton, Paul Stoodley, Aaron W. Reinke, Gabrielle L. Boulianne, Daniel J. Wozniak, Joe J. Harrison, Matthew R. Parsek, P. Lynne Howell
Publikováno v:
npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix determinants in bacteria. In Pseudomonas aeruginosa, Pel is crucial for cell-to-cell interactions and reducing susceptibility to antibiotic and mucolytic
Externí odkaz:
https://doaj.org/article/e6a5730ac34e41929995818e03acb97c
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract The filamentous fungus Aspergillus fumigatus is an ubiquitous mold that can cause invasive pulmonary infections in immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance resistance to antifungals and immune
Externí odkaz:
https://doaj.org/article/ff4c0885619c41afa65d8ea307718eea
Autor:
François Le Mauff, Erum Razvi, Courtney Reichhardt, Piyanka Sivarajah, Matthew R. Parsek, P. Lynne Howell, Donald C. Sheppard
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-7 (2022)
The structure of the Pel exopolysaccharide from Pseudomonas aeruginosa is fully characterized.
Externí odkaz:
https://doaj.org/article/4c56443ea27d41ecbc3e526a0a6e47fb
Autor:
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jürgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Eosinophilia is associated with various persisting inflammatory diseases and often coincides with chronic fungal infections or fungal allergy as in the case of allergic bronchopulmonary aspergillosis (ABPA). Here, we show that intranasal adm
Externí odkaz:
https://doaj.org/article/92daf7c4ba564f7e9c3b9b84d49251f7
Autor:
Quynh T Phan, Norma V Solis, Jianfeng Lin, Marc Swidergall, Shakti Singh, Hong Liu, Donald C Sheppard, Ashraf S Ibrahim, Aaron P Mitchell, Scott G Filler
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010681 (2022)
During hematogenously disseminated candidiasis, blood borne fungi must invade the endothelial cells that line the blood vessels to infect the deep tissues. Although Candida albicans, which forms hyphae, readily invades endothelial cells, other medica
Externí odkaz:
https://doaj.org/article/743b5ca3cf9542828ee062ad7674967c
Autor:
Joshua D. Kerkaert, François Le Mauff, Benjamin R. Wucher, Sarah R. Beattie, Elisa M. Vesely, Donald C. Sheppard, Carey D. Nadell, Robert A. Cramer
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Alanine metabolism has been suggested as an adaptation strategy to oxygen limitation in organisms ranging from plants to mammals. Within the pulmonary infection microenvironment, Aspergillus fumigatus forms biofilms with steep oxygen gradien
Externí odkaz:
https://doaj.org/article/3bd073db2b1b4278a1251f0c1e9a963e
Autor:
Natalie C. Bamford, François Le Mauff, Jaime C. Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a foundi
Externí odkaz:
https://doaj.org/article/bc12a17a65694000bd265c5f6442da5e
Autor:
George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. LiPuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. DePas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan, Michael A. Henson, Dean R. Madden, Jared R. Mayers, Carey Nadell, Dianne Newman, Alice Prince, Damian W. Rivett, Joseph D. Schwartzman, Daniel Schultz, Donald C. Sheppard, Alan R. Smyth, Melanie A. Spero, Bruce A. Stanton, Paul E. Turner, Chris van der Gast, Fiona J. Whelan, Rachel Whitaker, Katrine Whiteson
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways o
Externí odkaz:
https://doaj.org/article/1ed07d7593e74bbf8897df772ce78eb2