Dissociable genetic contributions to error processing: a multimodal neuroimaging study.

Autor: Yigal Agam, Mark Vangel, Joshua L Roffman, Patience J Gallagher, Jonathan Chaponis, Stephen Haddad, Donald C Goff, Jennifer L Greenberg, Sabine Wilhelm, Jordan W Smoller, Dara S Manoach

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101784 (2014)

Neuroimaging studies reliably identify two markers of error commission: the error-related negativity (ERN), an event-related potential, and functional MRI activation of the dorsal anterior cingulate cortex (dACC). While theorized to reflect the same

Externí odkaz: https://doaj.org/article/bcb8ef10f6a541fbbc499d12b9d79290

A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.

Autor: Joshua L Roffman, Adam Z Nitenson, Yigal Agam, Marlisa Isom, Jesse S Friedman, Kara A Dyckman, David G Brohawn, Jordan W Smoller, Donald C Goff, Dara S Manoach

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25253 (2011)

Responding to errors is a critical first step in learning from mistakes, a process that is abnormal in schizophrenia. To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic

Externí odkaz: https://doaj.org/article/a53ce123cb8740fb8c1a1de7d661d0dd

Impairment in acquisition of conditioned fear in schizophrenia

Autor: Liana Romaniuk, Jeremy Hall, Mohammed R. Milad, Donald C. Goff, Daphne J. Holt, Lauri Tuominen

Publikováno v: Neuropsychopharmacology
Tuominen, L, Romaniuk, L, Milad, M R, Goff, D C, Hall, J & Holt, D J 2021, ' Impairment in acquisition of conditioned fear in schizophrenia ', Neuropsychopharmacology . https://doi.org/10.1038/s41386-021-01193-1

Individuals with schizophrenia show impairments in associative learning. One well-studied, quantifiable form of associative learning is Pavlovian fear conditioning. However, to date, studies of fear conditioning in schizophrenia have been inconclusiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1883702c900949358706f5c090e2ab97
https://doi.org/10.1038/s41386-021-01193-1

Decreased Basal Ganglia and Thalamic Iron in Early Psychotic Spectrum Disorders are Associated with Increased Psychotic and Schizotypal Symptoms

Autor: Yu Veronica Sui, Faye McKenna, Hilary Bertisch, Pippa Storey, Rebecca Anthopolos, Donald C. Goff, Alexey Samsonov, Mariana Lazar

Publikováno v: Mol Psychiatry

Iron deficits have been reported as a risk factor for psychotic spectrum disorders (PSD). However, examinations of brain iron in PSD remain limited. The current study employed quantitative MRI to examine iron content in several iron-rich subcortical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b717619105a3a2280dc59e3bc22dbe0
https://europepmc.org/articles/PMC9772130/

Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia

Autor: Jijun Wang, YanYan Wei, Jinhong Wang, HuiRu Cui, Botao Zeng, Yuping Jia, Tianhong Zhang, Junjie Wang, Lihua Xu, Wenjun Su, Donald C. Goff, Yingying Tang, Tianyuan Zhu

Publikováno v: Brain Imaging and Behavior. 15:1748-1759

D-amino acid oxidase activator (DAOA) gene, which plays a crucial role in the process of glutamatergic transmission and mitochondrial function, is frequently linked with the liability for schizophrenia. We aimed to investigate whether the variation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0431d20564ce7e9bb65b66bb172d3184
https://doi.org/10.1007/s11682-020-00368-6