Výsledky vyhledávání

Abstract 243: Modeling of Diastolic Dysfunction in Induced Pluripotent Stem Cell-derived Cardiomyocytes From Hypertrophic Cardiomyopathy Patients

Autor: Huaxiao Yang, Alex C.Y. Chang, Helen M. Blau, Ning Ma, Karim Sallam, Donald Bers, Chi Keung Lam, Joe Zhang, June-Wha Rhee, Haodi Wu, Joseph C. Wu

Publikováno v: Circulation Research. 123

Aims: Diastolic dysfunction (DD) is common among hypertrophic cardiomyopathy (HCM) patients, causing major morbidity and mortality. Yet its cellular mechanisms are not fully understood, and presently, there is no effective treatment. Patient-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d7ef2c00fcdd6e3e1157ec4f6543b1c
https://doi.org/10.1161/res.123.suppl_1.243

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Angiotensin II signalling kicks out p27Kip1: casein kinase 2 augmentation of Cav1.2 L-type Ca2+channel activity in immature ventricular cardiomyocytes

Autor: Johannes W Hell, Donald Bers, Mary Horne

Publikováno v: The Journal of Physiology. 595:4131-4132

Ca2+ influx via the L-type Ca2+ channel Cav1.2 triggers our heartbeat. Perinatally and particularly at birth, angiotensin II is produced to augment necessary physiological changes in blood flow such as pulmonary perfusion. This article is protected b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b9280cdc141e97f972ddcadc4bbdeee
https://doi.org/10.1113/jp274260

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Elektronická kniha

Excitation-Contraction Coupling and Cardiac Contractile Force

Autor: Donald Bers

The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be us

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Abstract 58: Modeling Pathogenesis in Familial Hypertrophic Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells

Autor: Feng lan, Andrew Lee, Ping Liang, Enrique Navarrete, Li Wang, Han Leng, Veronica Sanchez, Michelle Yen, Yongming Wang, Patricia Nguyen, Ning Sun, Oscar Abilez, Richard Lewis, Yoshinori Yamaguchi, Euan Ashley, Donald Bers, Robert Robbins, Michael Longaker, Joseph Wu

Publikováno v: Circulation Research. 111

Background: Hypertrophic cardiomyopathy (HCM) is a prevalent familial cardiac disorder linked to development of heart failure, arrhythmia, and sudden cardiac death. Molecular genetic studies have demonstrated HCM is caused by mutations in genes encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be123624d8d240567d5563724bc033f1
https://doi.org/10.1161/res.111.suppl_1.a58

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Abstract 802: Dynamic FRET-Based Ca-Calmodulin Measurements in Intact Ventricular Myocytes Uncover Differential Signal Integration Due to Ca-Calmodulin Affinity

Autor: Qiujing Song, Julie Bossuyt, Jeffrey Saucerman, Donald Bers

Publikováno v: Circulation. 116

Background: Myocyte [Ca] i varies beat-to-beat and calmodulin (CaM) transduces Ca signals to regulate many cardiac functions (e.g. via CaM-dependent kinase, CaMKII, and calcineurin, CaN). We hypothesize that the different Ca-CaM affinities of CaMKII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::753b0b60da4f7c04ee67589cca21bbec
https://doi.org/10.1161/circ.116.suppl_16.ii_155

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