Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Donald B. Spencer"'
Publikováno v:
Journal of Biological Chemistry. 270:19816-19822
We report the results of a stopped-flow kinetic evaluation of the folding of human growth hormone (hGH). The results are compared with those obtained for a disulfide-modified analog in which the four cysteine residues have been reduced and alkylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdadb88449c0d3980a868c2af0bfc6aa
https://doi.org/10.1074/jbc.270.34.19816
https://doi.org/10.1074/jbc.270.34.19816
Autor:
Alita Miller, Steven R. Maple, Allen H. Pekar, Donald B. Spencer, David N. Brems, Christopher Bryant, Diane Lee Bakaysa, Karen S. McCune
Publikováno v:
Biochemistry. 32:8075-8082
The effect of pH on the conformational stability of insulin was studied. Surprisingly, the Gibbs free energy of unfolding increased approximately 30% by acidification. pH titration of insulin's conformational stability is described by a transition in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbfb6fb7d884e176aa2a23207375ba8
https://doi.org/10.1021/bi00083a004
https://doi.org/10.1021/bi00083a004
Publikováno v:
Biochemistry. 31(25)
The cis/trans isomerization of the peptide bond preceding proline residues in proteins can limit the rate at which a protein folds to its native conformation. Mutagenic analyses of dihydrofolate reductase (DHFR) from Escherichia coli show that this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00dd7e72e9ceea707016930df342f040
https://pubmed.ncbi.nlm.nih.gov/1610817
https://pubmed.ncbi.nlm.nih.gov/1610817
Publikováno v:
Experimental Biology and Medicine. 93:361-366
Summary1) Two patients with choriocarcinoma and one with chorioadenoma destruens with proven progressive metastases were treated with methotrexate, a folic acid antagonist, according to intensive regimen of repeated courses of dosages producing subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab270831e5e999beee422928c1f004e
https://doi.org/10.3181/00379727-93-22757
https://doi.org/10.3181/00379727-93-22757
Autor:
Donald B. Spencer, Sam G. Wildman
Publikováno v:
Biochemistry. 3:954-959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b55bfd9c293618cc5b74da444d018c
https://doi.org/10.1021/bi00895a019
https://doi.org/10.1021/bi00895a019