Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Donald B. Jump"'
Autor:
Jyothi Padiadpu, Melinda H. Spooner, Zhipeng Li, Nolan Newman, Christiane V. Löhr, K. Denise Apperson, Amiran Dzutsev, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun, Donald B. Jump
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
BackgroundNonalcoholic fatty liver disease (NAFLD) is a global health problem. Identifying early gene indicators contributing to the onset and progression of NAFLD has the potential to develop novel targets for early therapeutic intervention. We repo
Externí odkaz:
https://doaj.org/article/46edeae843a44a259ad0dbc2f51e195b
Autor:
Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, Manuel García-Jaramillo, Renee Greer, Christopher Gaulke, Franziska Bauchinger, Hyekyoung You, Jacob W. Pederson, Stephany Vasquez-Perez, Kimberly D. White, Briana Frink, Benjamin Philmus, Donald B. Jump, Giorgio Trinchieri, David Berry, Thomas J. Sharpton, Amiran Dzutsev, Andrey Morgun, Natalia Shulzhenko
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating effects of the diet. Herein, we use a data-driven approach (Transkingdom Network
Externí odkaz:
https://doaj.org/article/2d75b1d838834d4e88d47f7baca85691
Autor:
D. Elizabeth Le, Manuel García-Jaramillo, Gerd Bobe, Armando Alcazar Magana, Ashish Vaswani, Jessica Minnier, Donald B. Jump, Diana Rinkevich, Nabil J. Alkayed, Claudia S. Maier, Sanjiv Kaul
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: While oxylipins have been linked to coronary artery disease (CAD), little is known about their diagnostic and prognostic potential.Objective: We tested whether plasma concentration of specific oxylipins may discriminate among number of di
Externí odkaz:
https://doaj.org/article/a2a4a033b1694a12b6d47c65600741e9
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1936-1946 (2015)
DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr−/− mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induc
Externí odkaz:
https://doaj.org/article/1cebf0b2cee442b6b20863d424e37037
Autor:
Sasmita Tripathy, Kelli A. Lytle, Robert D. Stevens, James R. Bain, Christopher B. Newgard, Andrew S. Greenberg, Li-Shin Huang, Donald B. Jump
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1448-1464 (2014)
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (
Externí odkaz:
https://doaj.org/article/681d31295d0247bf9e5e0f7fb808078a
Autor:
Katie M. Lebold, Jay S. Kirkwood, Alan W. Taylor, Jaewoo Choi, Carrie L. Barton, Galen W. Miller, Jane La Du, Donald B. Jump, Jan Frederik Stevens, Robert L. Tanguay, Maret G. Traber
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 105-113 (2014)
To test the hypothesis that embryogenesis depends upon α-tocopherol (E) to protect embryo polyunsaturated fatty acids (PUFAs) from lipid peroxidation, new methodologies were applied to measure α-tocopherol and fatty acids in extracts from saponifie
Externí odkaz:
https://doaj.org/article/baeb7803871346938e76286cc7b27465
Publikováno v:
Metabolites, Vol 9, Iss 11, p 252 (2019)
Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and primary hepatocellular cancer (HCC). Obesity and type 2 diabete
Externí odkaz:
https://doaj.org/article/95aa1cd29fe24676a978ddd5e458af50
Autor:
Sasmita Tripathy, Donald B. Jump
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 71-84 (2013)
Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content, and suppresses expression of genes involved in gluconeogenesis (GNG). In this report, we define the molecular and metabolic bas
Externí odkaz:
https://doaj.org/article/eb35ed798ce745328c0e99d1b05e5db0
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2525-2545 (2012)
Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C20–22ω 3 polyunsaturated fatty acids (PUFA)], blood levels of C20–22ω
Externí odkaz:
https://doaj.org/article/1927a18863e1432397ab668f6b0cb5e5
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2642-2654 (2010)
Elevated hepatic fatty acid elongase-5 (Elovl5) activity lowers blood glucose in fasted chow-fed C57BL/6J mice. As high-fat diets induce hyperglycemia and suppress hepatic Elovl5 activity, we tested the hypothesis that elevated hepatic Elovl5 express
Externí odkaz:
https://doaj.org/article/64f9dacef681460585684c53254a3a23