Synthesis, Internalization and Visualization of N-(4-Carbomethoxy) Pyrrolidone Terminated PAMAM [G5:G3-TREN] Tecto(dendrimers) in Mammalian Cells

Autor: Maciej Studzian, Paula Działak, Łukasz Pułaski, David M. Hedstrand, Donald A. Tomalia, Barbara Klajnert-Maculewicz

Publikováno v: Molecules, Vol 25, Iss 19, p 4406 (2020)

Tecto(dendrimers) are well-defined, dendrimer cluster type covalent structures. In this article, we present the synthesis of such a PAMAM [G5:G3-(TREN)]-N-(4-carbomethoxy) pyrrolidone terminated tecto(dendrimer). This tecto(dendrimer) exhibits nontra

Externí odkaz: https://doaj.org/article/12651fedb9cd425ab712eee1083ca1b0

A Serendipitous Journey Leading to My Love of Dendritic Patterns and Chemistry

Autor: Donald A. Tomalia

Publikováno v: Molecules, Vol 23, Iss 4, p 824 (2018)

As the oldest of four Midwestern boys who were offsprings of an accountant and a housewife, each with less than a formal high school degree, we were blessed to have such parents.[...]

Externí odkaz: https://doaj.org/article/9a6b6bf9cad846a38bcbafb1cde463c0

Critical evaluation of the interaction of special proteins with human stratum corneum via terahertz scanning reflectometry and spectrometry

Autor: Donald A. Tomalia, Zia Shariat-Madar, Kariah Crosby, Kera F Crawford, Aunik K. Rahman, Bozena Michniak-Kohn, Anis Rahman

Publikováno v: Precision Nanomedicine

Many patients with chronic skin disease develop hemostatic abnormalities. The blood coagulation factor XII is a multifunctional protease, which is involved in thrombosis, fibrinolysis, and inflammatory processes. The aim of this investigation was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c54f64a692d85bca40ef0b010f5c14
https://doi.org/10.33218/prnano2(2).181218.2

Early Goddard Contributions Confirming the Dendritic State: Engineering PAMAM Dendrimer CNDPs to Generate CW-Terahertz Radiation Suitable for Molecular, Bio- and Diagnostics Imaging Spectroscopy

Autor: Donald A. Tomalia

Publikováno v: Computational Materials, Chemistry, and Biochemistry: From Bold Initiatives to the Last Mile ISBN: 9783030187774

Essentially, all new disruptive discoveries/technologies begin with a predictable period of disbelief and rejection. In some cases, progress or delay of acceptance is determined by access to special experimental instrumentation or emerging new charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92a8cdead436be6d0c3449a981dd52ba
https://doi.org/10.1007/978-3-030-18778-1_39

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Autor: Ling Peng, Nikos Kostomitsopoulos, Stephanie Dorman, Edmund Wilkes, Joanna Nicholls, Isabella Reccia, Katherine Czysz, John J. Rossi, Vikash Reebye, Pål Sætrom, Nagy A. Habib, Simona Ciriello, Hong-Shiee Lai, Donald A. Tomalia, Pedro R. Cutillas, Robert Habib, Kai-Wen Huang

Publikováno v: Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Nature Publishing Group, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy-Nucleic Acids, Elsevier, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy-Nucleic Acids, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy. Nucleic Acids

International audience; Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e7732f7c883d8d12f47841d498fcfc
https://hal.archives-ouvertes.fr/hal-02480317