Zobrazeno 1 - 10
of 583
pro vyhledávání: '"Donald A. Prough"'
Autor:
Tuvshintugs Baljinnyam, Yosuke Niimi, John R. Salsbury, Satoshi Fukuda, Casey M. Ouellette, Clark R. Andersen, Yasutaka Hirasawa, Donald A. Prough, C. Edwin Garner, Andrew L. Salzman, Perenlei Enkhbaatar
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Characterization of the pathophysiology of ARDS following chlorine gas inhalation in clinically relevant translational large animal models is essential, as the opportunity for clinical trials in this type of trauma is extremely limited. To i
Externí odkaz:
https://doaj.org/article/92f5f5112ba446bf8f9d92c0a9c0e0f1
Autor:
Cordell Cunningham, Christian Tapking, Michael Salter, Roger Seeton, George C. Kramer, Donald S. Prough, Melinda Sheffield-Moore, Michael P. Kinsky
Publikováno v:
Perioperative Medicine, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract Background Organ function is known to decline with age. Optimizing cardiac, pulmonary and renal function in older adults has led to significant improvements in perioperative care. However, when substantial blood loss and fluid shifts occur,
Externí odkaz:
https://doaj.org/article/1012044452664c2bb64f96de5980432b
Autor:
Kento Homma, Nikolay Bazhanov, Kazuki Hashimoto, Masaru Shimizu, Thomas Heathman, Qi Hao, Ranjana Nawgiri, Vidarshi Muthukumarana, Jae Woo Lee, Donald S. Prough, Perenlei Enkhbaatar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe pathogenesis of sepsis is an imbalance between pro-inflammatory and anti-inflammatory responses. At the onset of sepsis, the lungs are severely affected, and the injury progresses to acute respiratory distress syndrome (ARDS), with a
Externí odkaz:
https://doaj.org/article/7200a633c0aa4309b859dd6538b89688
Autor:
Satoshi Fukuda, Yosuke Niimi, Yasutaka Hirasawa, Ennert R. Manyeza, C. Edwin Garner, Garry Southan, Andrew L. Salzman, Donald S. Prough, Perenlei Enkhbaatar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modu
Externí odkaz:
https://doaj.org/article/0a205f198d544ea58822c974d20c9099
Autor:
Yosuke Niimi, Dannelys Pérez-Bello, Koji Ihara, Satoshi Fukuda, Sam Jacob, Clark R. Andersen, Tuvshintugs Baljinnyam, Jisoo Kim, Suzan Alharbi, Donald S. Prough, Perenlei Enkhbaatar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract This study investigated the efficacy of Omega-7 isolated from the sea buckthorn oil (Polyvit Co., Ltd, Gangar Holding, Ulaanbaatar, Mongolia) in ovine burn wound healing models. In vitro, proliferation (colony-forming rate) and migration (sc
Externí odkaz:
https://doaj.org/article/ff39f71cdc104a4c97eb231c4c1d4253
Autor:
Harris A. Weisz, Deborah Kennedy, Steven Widen, Heidi Spratt, Stacy L. Sell, Christine Bailey, Melinda Sheffield-Moore, Douglas S. DeWitt, Donald S. Prough, Harvey Levin, Claudia Robertson, Helen L. Hellmich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract High-throughput sequencing technologies could improve diagnosis and classification of TBI subgroups. Because recent studies showed that circulating microRNAs (miRNAs) may serve as noninvasive markers of TBI, we performed miRNA-seq to study T
Externí odkaz:
https://doaj.org/article/c734795419e6481684153ad2356800bb
Autor:
Harris A. Weisz, Deborah R. Boone, William S. Coggins, Gabrielle A. Edwards, Hannah E. Willey, Steven G. Widen, Dionicio Siegel, Andrew T. Nelson, Donald S. Prough, Helen L. Hellmich
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Evaluating novel compounds for neuroprotective effects in animal models of traumatic brain injury (TBI) is a protracted, labor-intensive and costly effort. However, the present lack of effective treatment options for TBI, despite decades of research,
Externí odkaz:
https://doaj.org/article/db582d781c84428caddccf89f35d1893
Autor:
James L. Sowers, Mark L. Sowers, Alexander S. Shavkunov, Bridget E. Hawkins, Ping Wu, Douglas S. DeWitt, Donald S. Prough, Kangling Zhang
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103108- (2021)
Summary: The release of excess glutamate following traumatic brain injury (TBI) results in glutamate excitotoxicity and metabolic energy failure. Endogenous mechanisms for reducing glutamate concentration in the brain parenchyma following TBI are poo
Externí odkaz:
https://doaj.org/article/ecf19e6a96b14dc49a8fb377e9d5d3fb
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 341-343 (2020)
The availability of clinical-relevant large animal models for research in wound healing study is limited. Although a few reports described the wound dressing fixation method using polyurethane foam in patients, no animal studies were conducted to inv
Externí odkaz:
https://doaj.org/article/92284597762242428685ebf520667196
Autor:
Osamu Fujiwara, Satoshi Fukuda, Ernesto Lopez, Yaping Zeng, Yosuke Niimi, Douglas S. DeWitt, David N. Herndon, Donald S. Prough, Perenlei Enkhbaatar
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background Sepsis is one of the most frequent causes of death in the intensive care unit. Host vascular hypo-responsiveness to vasopressors during septic shock is one of the challenging problems. This study tested the hypothesis that adjunct
Externí odkaz:
https://doaj.org/article/b7fb8777160f4d51a05f6704dcbb28ac