Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Donald A. Mcclain"'
Autor:
Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101715- (2023)
Objective: A buildup of skeletal muscle plasma membrane (PM) cholesterol content in mice occurs within 1 week of a Western-style high-fat diet and causes insulin resistance. The mechanism driving this cholesterol accumulation and insulin resistance i
Externí odkaz:
https://doaj.org/article/034b5171489647b9bf0aa2bbe510d46e
Autor:
Janet B. McGill, Mariko Johnson, Stacy Hurst, William T. Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donald A. McClain, Lisa de las Fuentes, Victor G. Davila-Roman, Daniel S. Ory, Samuel A. Wickline, Clay F. Semenkovich
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. T
Externí odkaz:
https://doaj.org/article/883cd46428644f2bb3fe9700c5ff28bf
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 18, Iss , Pp - (2019)
Aims: Clinical visits of non-diabetic patients reporting hypoglycemic symptoms are common in endocrinology practices, but remain understudied and lack clinical definition and evidence-based recommendations for diagnosis or treatment. Our goal was to
Externí odkaz:
https://doaj.org/article/75eb6515b17d46d5885e8302c3d064d8
Autor:
Kylie Kavanagh, Stephen M. Day, Morgan C. Pait, William R. Mortiz, Christopher B. Newgard, Olga Ilkayeva, Donald A. Mcclain, Shannon L. Macauley
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Epidemiological studies suggest that individuals with type 2 diabetes (T2D) have a twofold to fourfold increased risk for developing Alzheimer’s disease (AD), however, the exact mechanisms linking the two diseases are unknown. In both conditions, t
Externí odkaz:
https://doaj.org/article/038410c58ac243c385d46cac3e71dc68
Autor:
Ravinder Nagpal, Shaohua Wang, Leah C. Solberg Woods, Osborne Seshie, Stephanie T. Chung, Carol A. Shively, Thomas C. Register, Suzanne Craft, Donald A. McClain, Hariom Yadav
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Gut microbiome plays a fundamental role in several aspects of host health and diseases. There has been an exponential surge in the use of animal models that can mimic different phenotypes of the human intestinal ecosystem. However, data on host speci
Externí odkaz:
https://doaj.org/article/7c6e280759564b0fa7bf22ae93f30dff
Publikováno v:
Annual Review of Physiology. 85:339-362
High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal features: decreased insulin secretion, insulin resistance, and increased hepatic gluconeogenesis. This is true across the normal range of tissue iron leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ab47c8aee507c32a01eda91a77931c
https://doi.org/10.1146/annurev-physiol-022522-102832
https://doi.org/10.1146/annurev-physiol-022522-102832
Autor:
Gary E. Rosenthal, Donald A. McClain, Kevin P. High, Douglas Easterling, Angela Sharkey, Lynne E. Wagenknecht, Christopher O’Byrne, Rachel Woodside, Thomas K. Houston
Publikováno v:
Academic Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf22067a1643fd5e65e109fe22ff331
https://doi.org/10.1097/acm.0000000000005259
https://doi.org/10.1097/acm.0000000000005259
Publikováno v:
Diabetes. 71
The micronutrient iron is a risk factor for type II diabetes (T2D) . The effects of iron are, in part, mediated by the iron-sensing hypoxia inducible factor (HIF) pathway. The interactions of iron and hypoxia in the progression of T2D are not fully u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84de75ee760d552b482464d976538da
https://doi.org/10.2337/db22-223-lb
https://doi.org/10.2337/db22-223-lb
Publikováno v:
Diabetes. 71
The mechanism of action of MET (MET) remains controversial. MET induces an iron starvation response in yeast, so we hypothesized that tissue iron might influence MET responsiveness in higher organisms. We reviewed electronic health records to correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b82e275c4695a9779dc31123eec546b
https://doi.org/10.2337/db22-116-lb
https://doi.org/10.2337/db22-116-lb