Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Donald A. Belcher"'
Publikováno v:
Heliyon, Vol 9, Iss 5, Pp e15878- (2023)
Hemoglobin (Hb) based oxygen carriers (HBOCs) are designed to minimize the toxicity of extracellular Hb, while preserving its high oxygen-carrying capacity for oxygen delivery to cells. Polymerized human Hb (PolyHb) is a novel type of nanosized HBOC
Externí odkaz:
https://doaj.org/article/bc2855a17c1644e48ef0da159b4abea9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Fluid resuscitation following severe inflammation-induced hypoperfusion is critical for the restoration of hemodynamics and the prevention of multiorgan dysfunction syndrome during septic shock. Fluid resuscitation with commercially availabl
Externí odkaz:
https://doaj.org/article/c975693a2e82403babdaba58ccc0bc55
Autor:
Emre Eren, Sylvester M. Black, Brenda F. Reader, Eliza Beal, Clayton Cuddington, Donald A. Belcher, Andre F. Palmer, Bryan A. Whitson
Publikováno v:
ASAIO Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c85fa567eef8f0224bb1655f470192
https://doi.org/10.1097/mat.0000000000001918
https://doi.org/10.1097/mat.0000000000001918
Autor:
Donald A. Belcher, Alexander T. Williams, Carlos J. Munoz, Cynthia R. Muller, Cynthia Walser, Andre F. Palmer, Pedro Cabrales
Publikováno v:
J Appl Physiol (1985)
Ischemia-reperfusion injury increased vascular permeability, resulting in fluid extravasation from the intravascular compartment into the tissue space. Fluid and small protein extravasation lead to increased interstitial fluid pressure and capillary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9794162bcefe19c3b9a1f6b3b5211a89
https://doi.org/10.1152/japplphysiol.00117.2021
https://doi.org/10.1152/japplphysiol.00117.2021
Autor:
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191275 (2018)
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to incre
Externí odkaz:
https://doaj.org/article/db402f0e3f0b4bf1b7da163fb38606ff
Autor:
Donald Andrew Belcher, Uddyalok Banerjee, Christopher Michael Baehr, Kristopher Emil Richardson, Pedro Cabrales, François Berthiaume, Andre Francis Palmer
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185988 (2017)
Pure tense (T) and relaxed (R) quaternary state polymerized human hemoglobins (PolyhHbs) were synthesized and their biophysical properties characterized, along with mixtures of T- and R-state PolyhHbs. It was observed that the oxygen affinity of Poly
Externí odkaz:
https://doaj.org/article/5dd85d98cb884f0e8aecb4c6b0f75166
Autor:
Clayton T. Cuddington, Savannah R. Wolfe, Donald A. Belcher, Megan Allyn, Alisyn Greenfield, Xiangming Gu, Richard Hickey, Shuwei Lu, Tanmay Salvi, Andre F. Palmer
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(12)
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the oxygen (Osub2/sub) carrying capacity of PolyhHb makes it appealing as an Osub2/subthera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcd2c97ed594a7e990c48282ce3de42
https://pubmed.ncbi.nlm.nih.gov/36120842
https://pubmed.ncbi.nlm.nih.gov/36120842
Autor:
Pedro Cabrales, Donald A. Belcher, Alfredo Lucas, Alexander T. Williams, Carlos Munoz, Andre F. Palmer
Publikováno v:
Oncotarget, vol 11, iss 42
Oncotarget
Oncotarget
Cisplatin is a promising therapeutic for the treatment of non-small cell lung cancer (NSCLC). Unfortunately, a significant portion of NSCLC patients relapse due to cisplatin chemoresistance. This chemoresistance is thought to be primarily associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c0aeb246de4150a03abfcb171f17ab
https://doi.org/10.18632/oncotarget.27776
https://doi.org/10.18632/oncotarget.27776
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Administration of hemoglobin-based oxygen carriers (HBOCs) into the systemic circulation is a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of chemotherapeutics. Previous computational analysis indicated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ebf5edf37ea1b27df12daf1bb83a0a
http://link.springer.com/article/10.1038/s41598-020-68190-0
http://link.springer.com/article/10.1038/s41598-020-68190-0
Autor:
Andre F. Palmer, Xiangming Gu, Donald A. Belcher, Ivan S. Pires, Chintan Savla, Crystal Bolden-Rush, Clayton T. Cuddington
Publikováno v:
Biotechnol Bioeng
Previously, our lab developed high molecular weight (MW) tense (T) quaternary state glutaraldehyde polymerized bovine hemoglobins (PolybHbs) that exhibited reduced vasoactivity in several small animal models. In this work, we prepared PolybHb in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68572d3160cd60fd485e9f681738b8a2
https://doi.org/10.1002/bit.27382
https://doi.org/10.1002/bit.27382