Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Donald A Simone"'
Publikováno v:
Addiction Neuroscience, Vol 12, Iss , Pp 100168- (2024)
The Special Issue on Stress and Addiction is concerned with interrelationships between environmental stimuli such as stress and endogenous opioid systems that lead to addiction and other behaviors. Stress can have a profound effect on pain that is me
Externí odkaz:
https://doaj.org/article/bf712865fc424cfcac6dd0c959c61c96
Autor:
David J Matson, Darryl T Hamamoto, Howard Bregman, Melanie Cooke, Erin F DiMauro, Liyue Huang, Danielle Johnson, Xingwen Li, Jeff McDermott, Carrie Morgan, Ben Wilenkin, Annika B Malmberg, Stefan I McDonough, Donald A Simone
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138140 (2015)
While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological N
Externí odkaz:
https://doaj.org/article/0837a210c9304876b8143a23aa472839
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Aims Bone cancer produces severe pain that is treated with opioids, but serious side effects limit opioid utilization. There is therefore a need to develop effective and safe non‐opioid alternatives. The lipid mediator, Resolvin D1 (RvD1),
Externí odkaz:
https://doaj.org/article/20826b38ba244904b817eaa151787986
Autor:
Ratan K. Banik, Twan Sia, Mohab M. Ibrahim, Eellan Sivanesan, Megan Uhelski, Adrian Pena, John M. Streicher, Donald A. Simone
Publikováno v:
PAIN Reports, Vol 8, Iss 5, p e1097 (2023)
Abstract. Background:. This study investigated if a localized increase in skin temperature in rat models of incisional and inflammatory pain correlates with the intensity of spontaneous and evoked pain behaviors. Methods:. Anesthetized rats received
Externí odkaz:
https://doaj.org/article/1264a56e4adc4feca9a8357596d36a0a
Autor:
Iryna A. Khasabova, Jacob Gable, Malcolm Johns, Sergey G. Khasabov, Alexander E. Kalyuzhny, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, Virginia S. Seybold, Donald A. Simone
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches. Humanized transgenic mouse models have been inst
Externí odkaz:
https://doaj.org/article/d52cf4b8931e4d4a97173e7e6f955e02
Autor:
Giuseppe Cataldo, Mary M. Lunzer, Eyup Akgün, Henry L. Wong, Philip S. Portoghese, Donald A. Simone
Publikováno v:
Neuroscience. 516:54-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c048e45c72204f282d9c739b70b78754
https://doi.org/10.1016/j.neuroscience.2023.02.006
https://doi.org/10.1016/j.neuroscience.2023.02.006
Autor:
Megan L, Uhelski, Malcolm E, Johns, Alec, Horrmann, Sadiq, Mohamed, Ayesha, Sohail, Iryna A, Khasabova, Donald A, Simone, Ratan K, Banik
Publikováno v:
Molecular pain. 18
Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdde8811ee09494fc3fa2e16b6942904
https://pubmed.ncbi.nlm.nih.gov/36408567
https://pubmed.ncbi.nlm.nih.gov/36408567
Autor:
Iryna I. Khasabova, Joseph Juliette, Victoria M. Rogness, Sergey G. Khasabov, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, John D. Belcher, Gregory M. Vercellotti, Virginia S. Seybold, Donald A. Simone
Publikováno v:
Blood. 140(16)
In order to better understand mechanisms underlying acute pain during vaso-occlusive crises (VOCs) in patients with sickle cell disease, Khasabova et al report on a clinically relevant model in mice where VOC is stimulated by exposure to cold. Cold e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf74be60d0e81aa7d516729770bd64b
https://pubmed.ncbi.nlm.nih.gov/35960856
https://pubmed.ncbi.nlm.nih.gov/35960856
Autor:
Li-Lian Yuan, Lucy Vulchanova, Phu V. Tran, Montana B. Beeson, Victoria M. Rogness, Donald A. Simone, Sergey G. Khasabov
Publikováno v:
Neuroscience
Pain is a major health problem, affecting over fifty million adults in the US alone, with significant economic cost in medical care and lost productivity. Despite evidence implicating nicotinic acetylcholine receptors (nAChRs) in pathological pain, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5c0f71c477ad7e7b7c0d1bb3c8f5ab
https://doi.org/10.1016/j.neuroscience.2020.12.027
https://doi.org/10.1016/j.neuroscience.2020.12.027