Zobrazeno 1 - 10
of 419
pro vyhledávání: '"Donald A Morgan"'
Autor:
Tumininu S Faniyan, Xinyi Zhang, Donald A Morgan, Jorge Robles, Siresha Bathina, Paul S Brookes, Kamal Rahmouni, Rachel J Perry, Kavaljit H Chhabra
Publikováno v:
eLife, Vol 12 (2024)
The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose p
Externí odkaz:
https://doaj.org/article/2e669bfd729a4fe8806b8a45fdb3a01b
Autor:
Renata O Pereira, Alex Marti, Angela Crystal Olvera, Satya Murthy Tadinada, Sarah Hartwick Bjorkman, Eric Thomas Weatherford, Donald A Morgan, Michael Westphal, Pooja H Patel, Ana Karina Kirby, Rana Hewezi, William Bùi Trân, Luis Miguel García-Peña, Rhonda A Souvenir, Monika Mittal, Christopher M Adams, Kamal Rahmouni, Matthew J Potthoff, E Dale Abel
Publikováno v:
eLife, Vol 10 (2021)
Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood.
Externí odkaz:
https://doaj.org/article/c6e3dfd170734862af6b78cb638840db
Autor:
Deng-Fu Guo, Huxing Cui, Qihong Zhang, Donald A Morgan, Daniel R Thedens, Darryl Nishimura, Justin L Grobe, Val C Sheffield, Kamal Rahmouni
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005890 (2016)
Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determi
Externí odkaz:
https://doaj.org/article/92514b30f821463d935507322f537a10
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107206 (2014)
High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption
Externí odkaz:
https://doaj.org/article/97948389210748dc9296124eb31db10f
Autor:
Tamara R Castañeda, William Abplanalp, Sung Hee Um, Paul T Pfluger, Brigitte Schrott, Kimberly Brown, Erin Grant, Larissa Carnevalli, Stephen C Benoit, Donald A Morgan, Dean Gilham, David Y Hui, Kamal Rahmouni, George Thomas, Sara C Kozma, Deborah J Clegg, Matthias H Tschöp
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32631 (2012)
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dieta
Externí odkaz:
https://doaj.org/article/7da010e228ee4cde9cfbd8ad394306a7
Autor:
Mohamed Rouabhi, Deng-Fu Guo, Donald A. Morgan, Zhiyong Zhu, Miguel López, Leonid Zingman, Justin L. Grobe, Kamal Rahmouni
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101211- (2021)
Objectives: The hypothalamic ventromedial nucleus (VMH) plays a major role in metabolic control, but the molecular mechanisms involved remain poorly defined. We analyzed the relevance of the BBSome, a protein complex composed of 8 Bardet–Biedl synd
Externí odkaz:
https://doaj.org/article/ebac9cc55f5b42f999d32c2549e7184c
Autor:
Liliana Perdomo, Begoña Porteiro, Patricia Mallegol, Marcos Rios Garcia, Grégory Hilairet, Ismael González-García, Ramón Iglesias-Rey, Kamal Rahmouni, Verónica Rivas-Limeres, Jens Mittag, Cristina Contreras, Anxo Vidal, Donald A. Morgan, Rubén Nogueiras, Juan Carlos Roa, Ramaroson Andriantsitohaina, Edward Milbank, Manuel Tena-Sempere, Carlos Dieguez, Rebecca Oelkrug, Francesc Villarroya, Francisco Ruiz-Pino, Nathalia Romanelli Vicente Dragano, Juan Cuñarro, Miguel López, Aleix Gavaldà-Navarro, Luisa Vergori, Tomás Sobrino, Cristina García-Cáceres, M. Carmen Martinez
Publikováno v:
Nat. Metab. 3, 1415-1431 (2021)
Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in steroidogenic factor 1 (SF1) neurons of the ventromedial nucleus of the hypothal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fb87d6d344691ef77369cdd0a257d
https://doi.org/10.1038/s42255-021-00467-8
https://doi.org/10.1038/s42255-021-00467-8
Autor:
Anna Sieben, F. Thomas Wunderlich, Dong Kong, Xing Xiao, Peter Kloppenburg, André Kleinridders, Thomas E. Scammell, Gagik Yeghiazaryan, Simon Hess, A. Christine Hausen, Paul Klemm, Bradford B. Lowell, Jens C. Brüning, Kamal Rahmouni, Donald A. Morgan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in dorsal raphe nucleus-dorsal and -ventral, respectively. Serotonergic neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018121014cacedc640165017f559f8
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
Publikováno v:
Hypertension. 79
Mitochondria are best known as the powerhouse of the cell playing a critical role in energy metabolism with important implications in the development of obesity, a major cause of type 2 diabetes and hypertension. A-kinase anchoring protein 1 (AKAP1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8a98d8ca44079fbe41cc6cd019839e5
https://doi.org/10.1161/hyp.79.suppl_1.109
https://doi.org/10.1161/hyp.79.suppl_1.109
Autor:
Hussein Herz, Mohamad Mokadem, Kamal Rahmouni, Benjamin Linden, Meghan C. Naber, Yi Chu, Matthew J. Potthoff, Donald A. Morgan, Liping Tian
Publikováno v:
Obesity Surgery
Graphical abstract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6811a870fdbb345135fbde0911274d
http://europepmc.org/articles/PMC8458201
http://europepmc.org/articles/PMC8458201