Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Donald A Belcher"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008157 (2020)
Oxygen (O2) delivery facilitated by hemoglobin (Hb)-based O2 carriers (HBOCs) is a promising strategy to increase the effectiveness of chemotherapeutics for treatment of solid tumors. However, the heterogeneous vascular structures present within tumo
Externí odkaz:
https://doaj.org/article/1a978880b8ef4f4880fbcf0c7de38cb1
Autor:
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191275 (2018)
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to incre
Externí odkaz:
https://doaj.org/article/db402f0e3f0b4bf1b7da163fb38606ff
Autor:
Emre Eren, Sylvester M. Black, Brenda F. Reader, Eliza Beal, Clayton Cuddington, Donald A. Belcher, Andre F. Palmer, Bryan A. Whitson
Publikováno v:
ASAIO Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c85fa567eef8f0224bb1655f470192
https://doi.org/10.1097/mat.0000000000001918
https://doi.org/10.1097/mat.0000000000001918
Autor:
Donald A. Belcher, Alexander T. Williams, Carlos J. Munoz, Cynthia R. Muller, Cynthia Walser, Andre F. Palmer, Pedro Cabrales
Publikováno v:
J Appl Physiol (1985)
Ischemia-reperfusion injury increased vascular permeability, resulting in fluid extravasation from the intravascular compartment into the tissue space. Fluid and small protein extravasation lead to increased interstitial fluid pressure and capillary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9794162bcefe19c3b9a1f6b3b5211a89
https://doi.org/10.1152/japplphysiol.00117.2021
https://doi.org/10.1152/japplphysiol.00117.2021
Autor:
Clayton T. Cuddington, Savannah R. Wolfe, Donald A. Belcher, Megan Allyn, Alisyn Greenfield, Xiangming Gu, Richard Hickey, Shuwei Lu, Tanmay Salvi, Andre F. Palmer
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 119(12)
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the oxygen (Osub2/sub) carrying capacity of PolyhHb makes it appealing as an Osub2/subthera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcd2c97ed594a7e990c48282ce3de42
https://pubmed.ncbi.nlm.nih.gov/36120842
https://pubmed.ncbi.nlm.nih.gov/36120842
Publikováno v:
Heliyon. 9:e15878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3120bfbee38dd6f595962100aec49184
https://doi.org/10.1016/j.heliyon.2023.e15878
https://doi.org/10.1016/j.heliyon.2023.e15878
Autor:
Pedro Cabrales, Donald A. Belcher, Alfredo Lucas, Alexander T. Williams, Carlos Munoz, Andre F. Palmer
Publikováno v:
Oncotarget, vol 11, iss 42
Oncotarget
Oncotarget
Cisplatin is a promising therapeutic for the treatment of non-small cell lung cancer (NSCLC). Unfortunately, a significant portion of NSCLC patients relapse due to cisplatin chemoresistance. This chemoresistance is thought to be primarily associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c0aeb246de4150a03abfcb171f17ab
https://doi.org/10.18632/oncotarget.27776
https://doi.org/10.18632/oncotarget.27776
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Administration of hemoglobin-based oxygen carriers (HBOCs) into the systemic circulation is a potential strategy to relieve solid tumor hypoxia in order to increase the effectiveness of chemotherapeutics. Previous computational analysis indicated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ebf5edf37ea1b27df12daf1bb83a0a
http://link.springer.com/article/10.1038/s41598-020-68190-0
http://link.springer.com/article/10.1038/s41598-020-68190-0
Autor:
Andre F. Palmer, Xiangming Gu, Donald A. Belcher, Ivan S. Pires, Chintan Savla, Crystal Bolden-Rush, Clayton T. Cuddington
Publikováno v:
Biotechnol Bioeng
Previously, our lab developed high molecular weight (MW) tense (T) quaternary state glutaraldehyde polymerized bovine hemoglobins (PolybHbs) that exhibited reduced vasoactivity in several small animal models. In this work, we prepared PolybHb in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68572d3160cd60fd485e9f681738b8a2
https://doi.org/10.1002/bit.27382
https://doi.org/10.1002/bit.27382
Autor:
Clayton Cuddington, Savannah R. Wolfe, Donald A. Belcher, Megan Allyn, Alisyn Greenfield, Xiangming Gu, Richard Hickey, Shuwei Lu, Andre Palmer
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the O carrying capacity of PolyhHb makes it appealing as an O therapeutic, the commercial P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f437e748381f7017d1f9d95e60db76
https://doi.org/10.22541/au.164600516.65619478/v1
https://doi.org/10.22541/au.164600516.65619478/v1
