Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Donal MacGrogan"'
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/b229037d58a8450f8feb06a26fb52e0b
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 11, Iss 7, p 223 (2024)
Genome-wide association studies and experimental mouse models implicate the MIB1 and GATA6 genes in congenital heart disease (CHD). Their close physical proximity and conserved synteny suggest that these two genes might be involved in analogous cardi
Externí odkaz:
https://doaj.org/article/42399031bcc248a693d23cac5017361c
Autor:
Belén Prados, Raquel del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is
Externí odkaz:
https://doaj.org/article/d4a09a541c4243abba6f5b49417ad8d7
Autor:
Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa
Publikováno v:
eLife, Vol 8 (2019)
Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus
Externí odkaz:
https://doaj.org/article/e068dc4aa318465da0fa0ae32f43e0ae
Autor:
Lorriane Eley, Ahlam MS Alqahtani, Donal MacGrogan, Rachel V Richardson, Lindsay Murphy, Alejandro Salguero-Jimenez, Marcos Sintes Rodriguez San Pedro, Shindi Tiurma, Lauren McCutcheon, Adam Gilmore, José Luis de La Pompa, Bill Chaudhry, Deborah J Henderson
Publikováno v:
eLife, Vol 7 (2018)
Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the atrio
Externí odkaz:
https://doaj.org/article/e17c18854ec64554b19872782cc6fda1
Autor:
Joaquim Grego-Bessa, Paula Gómez-Apiñaniz, Belén Prados, Manuel José Gómez, Donal MacGrogan, José Luis de la Pompa
BACKGROUNDCardiac ventricles are essential for providing the contractile force of the beating heart throughout life. How the primitive endocardium-layered myocardial projections called trabeculae form and mature into the adult ventricles is of great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea4b346939bd917d40d559e686d815f
https://doi.org/10.1101/2022.11.28.518154
https://doi.org/10.1101/2022.11.28.518154
Autor:
Marcos Siguero-Álvarez, Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Jorge de la Barrera, Donal MacGrogan, Belén Prados, Fernando Sánchez-Sáez, Rebeca Piñeiro-Sabarís, Natalia Felipe-Medina, Carlos Torroja, Manuel José Gómez, María Sabater-Molina, Rubén Escribá, Ivonne Richaud-Patin, Olalla Iglesias-García, Mauro Sbroggio, Sergio Callejas, Declan P. O’Regan, Kathryn A. McGurk, Ana Dopazo, Giovanna Giovinazzo, Borja Ibañez, Lorenzo Monserrat, José María Pérez-Pomares, Fátima Sánchez-Cabo, Alberto M. Pendas, Angel Raya, Juan R. Gimeno-Blanes, José Luis de la Pompa
The complex genetics underlying human cardiac disease is evidenced by its heterogenous manifestation, multigenic basis, and sporadic occurrence. These features have hampered disease modeling and mechanistic understanding. Here, we show that 2 structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c9d5c2f3da4e9446d77a979ec3f9f2
http://hdl.handle.net/2445/193600
http://hdl.handle.net/2445/193600
Autor:
Joaquim Grego-Bessa, José Luis de la Pompa, Donal MacGrogan, Marcos Siguero-Álvarez, Rebeca Torregrosa-Carrión, Rebeca Piñeiro-Sabarís, Luis Luna-Zurita, Vitor Samuel Fernandes, Didier Y.R. Stainier
Publikováno v:
Science Advances
Description
Mouse and zebrafish genetic experiments demonstrate GPR126 requirement for placentation and dispensability for heart development.
Mutations in the G protein–coupled receptor GPR126/ADGRG6 cause human diseases, including defect
Mouse and zebrafish genetic experiments demonstrate GPR126 requirement for placentation and dispensability for heart development.
Mutations in the G protein–coupled receptor GPR126/ADGRG6 cause human diseases, including defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bbdef43f35574e3e6a48cc3197ed54
https://doi.org/10.1126/sciadv.abj5445
https://doi.org/10.1126/sciadv.abj5445
Autor:
Donal MacGrogan, José Luis de la Pompa
Publikováno v:
Circ Res
RATIONALE: Coronary artery disease (CAD) is the leading cause of death worldwide, but there are currently no methods to stimulate artery growth or regeneration in diseased hearts. Studying how arteries are built during development could illuminate st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965a2fcaa481ec8f2be98a82a1dbe8fd
https://hdl.handle.net/20.500.12105/15355
https://hdl.handle.net/20.500.12105/15355
Autor:
Tania Papoutsi, Simón Méndez-Ferrer, Donal MacGrogan, José Luis de la Pompa, Belén Prados, Raquel del Toro, Paula Gómez-Apiñániz, Pura Muñoz-Cánoves
Publikováno v:
Cell Death and Disease
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is controll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdf29e223ff8b933504c2131b630bea
http://hdl.handle.net/10230/48593
http://hdl.handle.net/10230/48593