Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Donal J. Cox"'
Autor:
Dearbhla M. Murphy, Anastasija Walsh, Laura Stein, Andreea Petrasca, Donal J. Cox, Kevin Brown, Emily Duffin, Gráinne Jameson, Sarah A. Connolly, Fiona O’Connell, Jacintha O’Sullivan, Sharee A. Basdeo, Joseph Keane, James J. Phelan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2898 (2024)
Neutrophils are dynamic cells, playing a critical role in pathogen clearance; however, neutrophil infiltration into the tissue can act as a double-edged sword. They are one of the primary sources of excessive inflammation during infection, which has
Externí odkaz:
https://doaj.org/article/0fcdcf15fdda40538d7cbf17238d2b37
Autor:
Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, Joseph Keane, Sharee A. Basdeo
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been r
Externí odkaz:
https://doaj.org/article/24b44d5422e842b18d691bd5b2e4fc5e
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Fergal D. Malone, Joseph Keane, Sharee A. Basdeo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The Warburg effect, defined as increased glycolysis and decreased oxidative phosphorylation, occurs in murine macrophages following LPS stimulation and is required for activation. There are differences between human and murine macrophage metabolic re
Externí odkaz:
https://doaj.org/article/dd41be26f8eb47d9beaaaaf1885151c4
Autor:
Donal J. Cox, Amy M. Coleman, Karl M. Gogan, James J. Phelan, Cilian Ó Maoldomhnaigh, Pádraic J. Dunne, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived macrophages (MDM) in the lung. Inf
Externí odkaz:
https://doaj.org/article/02d0040159e54ec2a417da3bfd05a263
Autor:
Christina Cahill, Fiona O’Connell, Karl M. Gogan, Donal J. Cox, Sharee A. Basdeo, Jacintha O’Sullivan, Stephen V. Gordon, Joseph Keane, James J. Phelan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2938 (2021)
For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on the rise and new therapies for
Externí odkaz:
https://doaj.org/article/75406c1e4d7a4d6cb6d088a2569f6700
Autor:
Fiona O'Connell, Christina Cahill, James J. Phelan, Joseph Keane, Donal J. Cox, Jacintha O'Sullivan, Cilian Ó'Maoldomhnaigh, Sharee A. Basdeo, Karl M. Gogan
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12189, p 12189 (2021)
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12189, p 12189 (2021)
Volume 22
Issue 22
Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were initially implemented based
Autor:
Seónadh O'Leary, Kate McQuaid, Lorraine Thong, Joseph Keane, Stephen V. Gordon, Gina Leisching, Dearbhla M. Murphy, Morgane Mitermite, Cilian Ó Maoldomhnaigh, Karl M. Gogan, Sharee A. Basdeo, Donal J. Cox, James J. Phelan, Amy M. Coleman
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Autor:
Éadaoin W. Griffin, Colm Cunningham, Carol L. Murray, Robert H. Field, Renata Rodrigues dos Reis, Orla Haugh, Ana Belen Lopez-Rodriguez, Lucas Silva Tortorelli, Lei Jin, Donal J. Cox, Ed C. Lavelle, Aisling Dunne, Arshed Nazmi, Edel Hennessy
Publikováno v:
Glia
Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during neurodegeneration, but
Autor:
Sharee A. Basdeo, Joseph Keane, Donal J. Cox, Fergal D. Malone, Cilian Ó Maoldomhnaigh, James J. Phelan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The Warburg effect, defined as increased glycolysis and decreased oxidative phosphorylation, occurs in murine macrophages following LPS stimulation and is required for activation. There are differences between human and murine macrophage metabolic re