Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.

Autor: Barkan DT; Discovery Sciences, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Garland K; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Zhang L; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Eastman RT; Global Health, Novartis Biomedical Research, Emeryville, California 94608, United States., Hesse M; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Knapp M; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Ornelas E; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Tang J; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Cortopassi WA; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Wang Y; Discovery Sciences, Novartis Biomedical Research, La Jolla, California 92121, United States., King F; Discovery Sciences, Novartis Biomedical Research, La Jolla, California 92121, United States., Jia W; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Nguyen Z; Discovery Sciences, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Frank AO; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Chan R; Global Health, Novartis Biomedical Research, Emeryville, California 94608, United States., Fang E; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Fuller D; Discovery Sciences, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Busby S; Discovery Sciences, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States., Carias H; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Donahue K; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Tandeske L; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Diagana TT; Global Health, Novartis Biomedical Research, Emeryville, California 94608, United States., Jarrousse N; Global Health, Novartis Biomedical Research, Emeryville, California 94608, United States., Moser H; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Sarko C; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States., Dovala D; Discovery Sciences, Novartis Biomedical Research, Emeryville, California 94608, United States., Moquin S; Global Health, Novartis Biomedical Research, Emeryville, California 94608, United States., Marx VM; Global Discovery Chemistry, Novartis Biomedical Research, Emeryville, California 94608, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17454-17471. Date of Electronic Publication: 2024 Sep 27.

KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment.

Autor: Carpenter ES; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan., Kadiyala P; Immunology Graduate Program, University of Michigan, Ann Arbor, Michigan., Elhossiny AM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan., Kemp SB; Department of Molecular and Cellular Pathology, University of Michigan, Ann Arbor, Michigan., Li J; Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan., Steele NG; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan., Nicolle R; Université Paris Cité, Centre de Recherche sur l'Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, Paris, France., Nwosu ZC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Freeman J; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Dai H; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Paglia D; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Du W; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Donahue K; Cancer Biology Program, University of Michigan, Ann Arbor, Michigan., Morales J; Cancer Biology Program, University of Michigan, Ann Arbor, Michigan., Medina-Cabrera PI; Cancer Biology Program, University of Michigan, Ann Arbor, Michigan., Bonilla ME; Cancer Biology Program, University of Michigan, Ann Arbor, Michigan., Harris L; Department of Surgery, University of Michigan, Ann Arbor, Michigan., The S; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan., Gunchick V; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan., Peterson N; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan., Brown K; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Mattea M; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan., Espinoza CE; Department of Surgery, University of Michigan, Ann Arbor, Michigan., McGue J; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Kabala SM; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Baliira RK; Cancer Biology Program, University of Michigan, Ann Arbor, Michigan., Renollet NM; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Mooney AG; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Liu J; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Bhalla S; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Farida JP; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Ko C; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Machicado JD; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Kwon RS; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Wamsteker EJ; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Schulman A; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Anderson MA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Law R; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Prabhu A; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan., Coulombe PA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan., Rao A; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan.; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan., Frankel TL; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Bednar F; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Surgery, University of Michigan, Ann Arbor, Michigan., Shi J; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Sahai V; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan., Pasca Di Magliano M; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan.; Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jun 03; Vol. 30 (11), pp. 2497-2513.

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An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice.

Autor: Vossen C; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Schmidt P; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Wunderlich CM; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Mittenbühler MJ; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Tapken C; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Wienand P; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany., Mirabella PN; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany., Cabot L; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany., Schumacher AL; FACS & Imaging Core Facility, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany., Folz-Donahue K; FACS & Imaging Core Facility, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany., Kukat C; FACS & Imaging Core Facility, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany., Voigt I; Transgenic Core Facility, Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, 50931 Cologne, Germany., Brüning JC; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.; Department of neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany., Fenselau H; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Research Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany., Wunderlich FT; Obesity and Cancer Research Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.; Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.

Publikováno v: Cells [Cells] 2024 Jan 04; Vol. 13 (1). Date of Electronic Publication: 2024 Jan 04.

Deep learning estimation of northern hemisphere soil freeze-thaw dynamics using satellite multi-frequency microwave brightness temperature observations.

Autor: Donahue K; Numerical Terradynamic Simulation Group, University of Montana, Missoula, MT, United States.; Department of Computer Science, University of Montana, Missoula, MT, United States., Kimball JS; Numerical Terradynamic Simulation Group, University of Montana, Missoula, MT, United States., Du J; Numerical Terradynamic Simulation Group, University of Montana, Missoula, MT, United States., Bunt F; Department of Computer Science, University of Montana, Missoula, MT, United States., Colliander A; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, United States., Moghaddam M; Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States., Johnson J; Department of Computer Science, University of Montana, Missoula, MT, United States., Kim Y; Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates., Rawlins MA; Department of Earth, Geographic, and Climate Sciences, University of Massachusetts, Amherst, MA, United States.

Publikováno v: Frontiers in big data [Front Big Data] 2023 Nov 17; Vol. 6, pp. 1243559. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).