Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Dona M, Chikaraishi"'
Publikováno v:
Journal of Neurochemistry. 76:201-209
The mechanisms for neuronal survival in the CNS are not well understood, but are likely to be complex due to possible autocrine and redundant neurotrophic support. Most studies have focused on the nerve growth factor (NGF)/TrkA pathway in peripheral
Autor:
Ole Isacson, C. Kim, H. Ishiguro, G. Feng, B.B. Kelly, Dona M. Chikaraishi, Eva Hedlund, Kwang-Soo Kim
Publikováno v:
Neuroscience. 142:343-354
Degeneration of the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson's disease. To facilitate the study of the differentiation and mainte- nance of this population of dopaminergic neurons both in vivo and in vitro, we generated
Autor:
Andrea L. Portbury, Marybeth Groelle, Rashmi Chandra, Margie Ream, Dona M. Chikaraishi, Alisa M Ray
Publikováno v:
Neonatology. 89:147-158
β-Adrenergic receptor (βAR) activation has been shown to maintain heart rate during hypoxia and to rescue the fetus from the fetal lethality that occurs in the absence of norepinephrine. This study examines whether the same subtype of βAR is respo
Publikováno v:
Journal of Neurochemistry. 94:731-741
Prolonged stress or chronic nicotine administration leads to induction of tyrosine hydroxylase (TH) in adrenal medulla and locus coeruleus (LC) of the rat. In this study we use mice that express a transgene encoding 4.5 kb of TH gene 5'-flanking regi
Publikováno v:
Molecular and Cellular Neuroscience. 25:536-547
In neurons and neuroendocrine cells, tyrosine hydroxylase (TH) gene expression is induced by stimuli that elevate cAMP, by depolarization, and by hypoxia. Using these stimuli, we examined TH promoter mutants, cAMP response element binding protein (CR
Autor:
Dona M. Chikaraishi, Heinz Breer, Xinhai Yang, Jürgen Krieger, John S. Kauer, James E. Marchand
Publikováno v:
The Journal of Comparative Neurology. 474:453-467
Physiological studies of odor-elicited responses from the olfactory epithelium and bulb in the tiger salamander, Ambystoma tigrinum, have elucidated a number of features of olfactory coding that appear to be conserved across several vertebrate specie
Autor:
Suzanne Roffler-Tarlov, Maribel Rios, Michael K. McMillian, Marybeth Groelle, Rashmi Chandra, Andrea L. Portbury, James Rene Herlong, Alana Elias, Dona M. Chikaraishi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H2069-H2077
Mice lacking catecholamines die before birth, some with cardiovascular abnormalities. To investigate the role of catecholamines in development, embryonic day 12.5 (E12.5) fetuses were cultured and heart rate monitored. Under optimal oxygenation, wild
Publikováno v:
Journal of Neurochemistry. 71:51-59
Recently, a tyrosine hydroxylase (TH)-expressing CNS-derived cell line, CAD, was obtained that is capable of undergoing reversible morphological differentiation. The isolation of the CAD line allowed us to ask whether different DNA regulatory element
Publikováno v:
The Journal of Neuroscience. 17:4076-4086
Transcription of the rat tyrosine hydroxylase (TH) gene is controlled by enhancer sequences in its 5′ flanking region; these enhancers include the AP1, dyad, and cAMP response element (CRE) motifs. We show that a novel basal promoter element (−17
Publikováno v:
The Journal of Neuroscience. 17:1217-1225
A CNS catecholaminergic cell line, Cath.a, was established by targeted oncogenesis in transgenic mice. Cath.a cells express neuronal properties but lack neuronal morphology. Here, we describe a variant of Cath.a, called CAD (Cath.a-differentiated), i