Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dona L. Dyer"'
Autor:
S. Dale Lewis, Elizabeth A. Lyle, I.-W. Chen, Julie A. Krueger, Jacquelynn J. Cook, Zhongguo Chen, Jiunn H. Lin, Joseph P. Vacca, Bruce D. Dorsey, Adel M. Naylor-Olsen, Jules A. Shafer, Joseph J. Lynch, Kellie J. Cutrona, Bobby J. Lucas, Colleen M. McDonough, Dona L. Dyer, Maria T. Stranieri, Sanderson Philip E, Kari Vastag, Stephen J. Gardell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:817-822
Replacement of the amidinopiperidine P1 group of 3-benzylsulfonylamino-6-methyl-2-pyridinone acetamide thrombin inhibitor L-373,890 (2) with a mildly basic 5-linked 2-amino-6-methylpyridine results in an equipotent compound L-374,087 (5, Ki = 0.5 nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d69b196c0e5ba566f3044b070724ad
https://doi.org/10.1016/s0960-894x(98)00117-6
https://doi.org/10.1016/s0960-894x(98)00117-6
Autor:
Steven J. Gardell, S. Dale Lewis, Bobby J. Lucas, Sanderson Philip E, A. M. Mulichak, Joseph P. Vacca, Adel M. Naylor-Olsen, Dona L. Dyer, Joseph J. Lynch, Elizabeth A. Lyle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1497-1500
L-373,890, a highly selective and efficacious pyridinone acetamide thrombin inhibitor was designed using a combination of X-ray crystallography, molecular modeling and empirical structure optimization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b503fc3c722430317200a34a5420546
https://doi.org/10.1016/s0960-894x(97)00257-6
https://doi.org/10.1016/s0960-894x(97)00257-6
Autor:
Sanderson Philip E, B. J. Jun. Lucas, S. D. Lewis, Elizabeth A. Lyle, Dona L. Dyer, A. M. Mulichak, J. P. Vacca, Stephen J. Gardell, Adel M. Naylor-Olsen, J.J. Lynch
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97813019fd6092389cd6cdeb1042e924
https://doi.org/10.1002/chin.199742179
https://doi.org/10.1002/chin.199742179
Autor:
Bobby J. Lucas, Sanderson Philip E, S. Dale Lewis, Julie A. Krueger, Youwei Yan, Lawrence C. Kuo, Kellie J. Cutrona, Dona L. Dyer
Publikováno v:
ChemInform. 34
Use of a chlorophenoxyacetamide P1 group with a pyridinone acetamide P2/P3 gave an exceptionally potent thrombin inhibitor (K(i)=40 pM). Truncation of the molecule at the N-terminus gave unique, low nanomolar, non-covalent thrombin inhibitors which d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644bb17b1227dd1557f368b9ff06e85f
https://doi.org/10.1002/chin.200318116
https://doi.org/10.1002/chin.200318116
Autor:
Bobby J. Lucas, S. Dale Lewis, and Jules A. Shafer, Stephen J. Gardell, Maria T. Stranieri, Timothy R. Hare, Kellie J. Cutrona, Joseph J. Lynch, Dona L. Dyer, Adel M. Naylor-Olsen, Joseph P. Vacca, Sanderson Philip E, Colleen M. McDonough, Kari Vastag, Julie A. Krueger, Youwei Yan, Bruce D. Dorsey, C. M. Cooper, Terry A. Lyle, Zhongguo Chen, Elizabeth A. Lyle, I.-W. Chen, Jacquelynn J. Cook, Jiunn H. Lin
Publikováno v:
Journal of medicinal chemistry. 41(23)
We have addressed the key deficiency of noncovalent pyridinone acetamide thrombin inhibitor L-374,087 (1), namely, its modest half-lives in animals, by making a chemically stable 3-alkylaminopyrazinone bioisostere for its 3-sulfonylaminopyridinone co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101908dac9992dec57b4ab69f9856a5d
https://pubmed.ncbi.nlm.nih.gov/9804686
https://pubmed.ncbi.nlm.nih.gov/9804686