Výsledky vyhledávání - "Dona L. Bamberger"

Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages

Autor: Dona L. Bamberger, Jackson B. Gibbs, Oliff Allen I, Nancy E. Kohl, Samuel L. Graham, Rands E, Thorsten E. Fisher, Robert L. Smith, Scott D. Mosser, John S. Wai, David L. Pompliano

Publikováno v: Bioorganic & Medicinal Chemistry. 2:939-947

Replacement of the central amino methylene linkage of C[psi CH2NH]A[psi CH2NH]AX tetrapeptide inhibitors with carbon tethers led to compounds with potency in the nanomolar range. Some of the more potent olefinic compounds inhibit Ras processing in in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f12a4866dd3e02468fdf30eda06577
https://doi.org/10.1016/s0968-0896(00)82043-x

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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs

Autor: Jacob M. Hoffman, Barnes Jl, Clarence S. Rooney, Anthony M. Smith, Thorsten E. Fisher, James H. Jones, Dona L. Bamberger, Thomas Cm, Theresa M. Williams, John S. Wai

Publikováno v: Journal of Medicinal Chemistry. 36:953-966

A new series of potent specific 2-pyridinone reverse transcriptase (RT) inhibitors was developed based on the preliminary development lead 3-[(phthalmido)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (3), a non-nucleoside derivative which exhibited weak a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5c0b5f792f834681aed512f1491311
https://doi.org/10.1021/jm00060a002

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ChemInform Abstract: Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1 Specific Reverse Transcriptase Inhibitors. Part 2. Analogues of 3-Aminopyridin- 2(1H)-one

Autor: W. S. Saari, J. H. Nunberg, Jacob M. Hoffman, Julie A. O'Brien, P. S. Anderson, J. H. Jones, Thorsten E. Fisher, M. E. Goldman, A. M. Smith, Quintero Julio C, C. M. Thomas, C. S. Rooney, William A. Schleif, Dona L. Bamberger, John S. Wai, Emilio A. Emini

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8ec53cb79fe90022353996fb2d6cdf8
https://doi.org/10.1002/chin.199320214

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ChemInform Abstract: Synthesis and Evaluation of 2-Pyridinone Derivatives as Specific HIV-1 Reverse Transcriptase Inhibitors. Part 3. Pyridyl and Phenyl Analogs of 3-Aminopyridin-2(1H)-one

Autor: John S. Wai, R. J. Hudcosky, Theresa M. Williams, Jacob M. Hoffman, J. H. Nunberg, S. C. Mactough, Quintero Julio C, W. S. Saari, P. S. Anderson, M. E. Goldman, Emilio A. Emini, William A. Schleif, C. M. Thomas, C. S. Rooney, Thorsten E. Fisher, Dona L. Bamberger, Julie A. O'Brien

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b0ed6d1993895e455d819a69fcbfedd
https://doi.org/10.1002/chin.199408204

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Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one

Autor: Jacob M. Hoffman, S. C. Mactough, Dona L. Bamberger, Thorsten E. Fisher, W. S. Saari, John S. Wai, Clarence S. Rooney, R. J. Hudcosky, Theresa M. Williams, Thomas Cm

Publikováno v: Journal of medicinal chemistry. 36(2)

In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors, a series of 3-[(pyridylmethyl)amino]- and 3-[(phenylmethyl)amino]-2-pyridinone derivatives was synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310255646dee6bd531f361bd8b87cfcb
https://pubmed.ncbi.nlm.nih.gov/7678654

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