Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dona Alberti"'
Autor:
Joel M. Reid, Dona Alberti, Jill M. Kolesar, Jens C. Eickhoff, Rebecca Marnocha, Renee M. McGovern, Howard H. Bailey, Zhisheng Jiang, Igor Espinoza-Delgado, Steven Attia, Matthew M. Ames, John J. Wright, George Wilding, Anne M. Traynor, Tien Hoang, William R. Schelman, Kyle D. Holen
Publikováno v:
Investigational New Drugs. 31:1539-1546
Background A phase I study to assess the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK) and antitumor activity of vorinostat in combination with bortezomib in patients with advanced solid tumors. Methods Patients re
Autor:
Glenn Liu, George Wilding, Dona Alberti, Jill M. Kolesar, Anne M. Traynor, Tabraiz A. Mohammed, Michael D. Keppen, Naoko Takebe, Jens C. Eickhoff, Rebecca Marnocha, William R. Schelman
Publikováno v:
Investigational New Drugs. 32:295-302
Background. A phase I, dose-escalation study of AT-101 with cisplatin and etoposide was conducted to determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), safety and pharmacokinetics in patients with advanced solid tumors, with
Autor:
Jens C. Eickhoff, William R. Schelman, Kamakshi Sachidanandam, Christopher R. Chitambar, William E. Antholine, Anne M. Traynor, James P. Thomas, Dona Alberti, Jill M. Kolesar, Kyle D. Holen, George Wilding
Publikováno v:
Experimental and Therapeutic Medicine. 2:119-123
PURPOSE: 3-AP (3-aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP) is a metal chelator that potently inhibits the enzyme ribonucleotide reductase, RR, which plays a key role in cell division and tumor progression. A sub-unit of RR has a non-hem
Autor:
Jens C. Eickhoff, Dona Alberti, James P. Thomas, Brian S. Choi, Jill M. Kolesar, S. Percy Ivy, George Wilding, Rebecca Marnocha, William R. Schelman, Kyle D. Holen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 66:973-980
3-AP is a ribonucleotide reductase inhibitor and has been postulated to act synergistically with other chemotherapeutic agents. This study was conducted to determine the toxicity and antitumor activity of 3-AP with irinotecan. Correlative studies inc
Autor:
C. Sidor, Check Quon, Glenn Liu, George Wilding, Amye J. Tevaarwerk, Dona Alberti, Jamie Arnott, Kyle D. Holen
Publikováno v:
Clinical Cancer Research. 15:1460-1465
Purpose: 2-Methoxyestradiol (2ME2; Panzem) is an endogenous, estradiol-17β metabolite that at pharmacologic doses exerts antimitotic and antiangiogenic activities. Studies with a 2ME2 capsule formulation showed limited oral bioavailability. We repor
Autor:
Zhisheng Jiang, Fred T. Lee, Rebecca Marnocha, Percy Ivy, Sherry Morgan-Meadows, Jill M. Kolesar, Marcia Pomplun, Dona Alberti, Jens C. Eickhoff, William R. Schelman, George Wilding, Wei Huang, Anne M. Traynor
Publikováno v:
Cancer Chemotherapy and Pharmacology. 63:1147-1156
To assess the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics and antitumor activity of Triapine administered in combination with doxorubicin.Patients were treated with doxorubicin intravenously (IV) on day 1 and Triapine
Autor:
Mary Jane Staab, Harish Ahuja, Jules H. Blank, Rebecca Marnocha, Alcee Jumonville, Dottie Horvath, Dona Alberti, Jens C. Eickhoff, Jane Straus, Michael Eastman, Michael Glode, Douglas G. McNeel, Glenn Liu, Steven Attia, George Wilding, Daniel H. Shevrin
Publikováno v:
Clinical Cancer Research. 14:2437-2443
Purpose: Docetaxel is standard of care for androgen-independent prostate cancer (AIPC). Doxercalciferol (1α-hydroxyvitamin D2) had modest activity in phase I/II trials. Preclinical data support combining vitamin D analogues with docetaxel to treat A
Autor:
Kyle D. Holen, William R. Schelman, William E. Antholine, Peter G. Geiger, Anne M. Traynor, Dona Alberti, Jill M. Kolesar, James P. Thomas, Christopher R. Chitambar, George Wilding
Publikováno v:
Journal of Inorganic Biochemistry. 102:693-698
The metal chelator Triapine ® , 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, is a potent inhibitor of ribonucleotide reductase. EPR spectra consistent with signals from Fe–transferrin, heme, and low-spin iron or cupric ion were observed in
Autor:
Dorthea Horvath, Mark A. Ritter, Edward M. Messing, Paul R. Hutson, Kurt R. Oettel, Jeffrey A. Douglas, George Wilding, Mary Jane Staab, Dona Alberti
Publikováno v:
Cancer Chemotherapy and Pharmacology. 62:373-377
Testosterone administration can lead to increased antipyrine clearance in humans. Medical or surgical castration is a standard treatment of progressive prostate carcinoma, but the effect of the subsequent fall of testosterone concentrations upon drug
Autor:
Rebecca Marnocha, Yulin Zhang, Michael S. Huie, George Wilding, Amy Drezen, Dona Alberti, Jeffrey A. Douglas, Lynn Van Ummersen, Dottie Horvath, Kurt R. Oettel, Mary Jane Staab, Mann Kim Kyung
Publikováno v:
Investigational New Drugs. 24:255-260
Objective: To assess the efficacy and toxicity of the combination of interferon-alpha and doxycycline in patients with metastatic renal cell carcinoma and to assess the effect of this treatment on serum vascular endothelial growth factor (VEGF) level