Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Don-On Daniel Mak"'
Autor:
Horia Vais, Min Wang, Karthik Mallilankaraman, Riley Payne, Chris McKennan, Jeffrey T Lock, Lynn A Spruce, Carly Fiest, Matthew Yan-lok Chan, Ian Parker, Steven H Seeholzer, J Kevin Foskett, Don-On Daniel Mak
Publikováno v:
eLife, Vol 9 (2020)
Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Wh
Externí odkaz:
https://doaj.org/article/dd23c45a2e9c46ebb92e8492d4b3087c
Autor:
Horia Vais, Karthik Mallilankaraman, Don-On Daniel Mak, Henry Hoff, Riley Payne, Jessica E. Tanis, J. Kevin Foskett
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 403-410 (2016)
The mitochondrial uniporter (MCU) is an ion channel that mediates Ca2+ uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca2+ signaling. Matrix Ca2+ concentration is similar to that in cytoplasm, despite an enormous driving f
Externí odkaz:
https://doaj.org/article/8734499e717c4d678ba27e2910d8ed3c
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004529 (2015)
Familial Alzheimer's disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Aβ) production-independent mann
Externí odkaz:
https://doaj.org/article/7e5e2b104e7e4abd990ca3f49c1e90de
Publikováno v:
Cell Calcium. 76:23-35
Intracellular accumulation of oligomeric forms of β amyloid (Aβ) are now believed to play a key role in the earliest phase of Alzheimer(′)s disease (AD) as their rise correlates well with the early symptoms of the disease. Extensive evidence poin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83fccefd9a1262329fdd1dca1d192cc
https://doi.org/10.1016/j.ceca.2018.09.003
https://doi.org/10.1016/j.ceca.2018.09.003
Autor:
Horia, Vais, Min, Wang, Karthik, Mallilankaraman, Riley, Payne, Chris, McKennan, Jeffrey T, Lock, Lynn A, Spruce, Carly, Fiest, Matthew Yan-Lok, Chan, Ian, Parker, Steven H, Seeholzer, J Kevin, Foskett, Don-On Daniel, Mak
Publikováno v:
eLife
Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eda83d6d159b4e7f26391615e8bc0584
https://pubmed.ncbi.nlm.nih.gov/32420875
https://pubmed.ncbi.nlm.nih.gov/32420875
Autor:
Ian Parker, Don-On Daniel Mak, John E. Pearson, Ghanim Ullah, Angelo Demuro, Syed Islamuddin Shah
Publikováno v:
Biophysical journal. 115(1)
Experimental records of single molecules or ion channels from fluorescence microscopy and patch-clamp electrophysiology often include high-frequency noise and baseline fluctuations that are not generated by the system under investigation and have to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba83afd6aeee0c0ad028053eb7971cd7
https://pubmed.ncbi.nlm.nih.gov/29972815
https://pubmed.ncbi.nlm.nih.gov/29972815
Publikováno v:
Biophysical Journal. 116:302a-303a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b174e12c7bef502986749a922b00a4
https://doi.org/10.1016/j.bpj.2018.11.1639
https://doi.org/10.1016/j.bpj.2018.11.1639
Autor:
J. Donald Joseph, Don-On Daniel Mak, King-Ho Cheung, J. Kevin Foskett, Huafeng Wei, Horia Vais, Yi Peng
Publikováno v:
Anesthesiology. 121:528-537
Background: Pharmacological evidence suggests that inhalational general anesthetics induce neurodegeneration in vitro and in vivo through overactivation of inositol trisphosphate receptor (InsP3R) Ca2+-release channels, but it is not clear whether th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d9b09353cb30d6851434e6428ea7a6
https://doi.org/10.1097/aln.0000000000000316
https://doi.org/10.1097/aln.0000000000000316
Publikováno v:
Biophysical Journal. 110(3)
Mutants in presenilins (PS1 or PS2) is the major cause of familial Alzheimer's disease (FAD). FAD causing PS mutants affect intracellular Ca(2+) homeostasis by enhancing the gating of inositol trisphosphate (IP3) receptor (IP3R) Ca(2+) release channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff56fd655ace328547b83d3562cdb780