Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Don Wai Ching Chin"'
Autor:
Carol Lai-Hung Cheng, Felice Hoi-Ching Tsang, Lai Wei, Mengnuo Chen, Don Wai-Ching Chin, Jialing Shen, Cheuk-Ting Law, Derek Lee, Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Chun-Ming Wong
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2. Its high levels are correlated with poor survival in HCC patients, and targeting i
Externí odkaz:
https://doaj.org/article/a00c4f2a8e644de8ab49c7c3c780d42a
Autor:
Lai Wei, Derek Lee, Cheuk-Ting Law, Misty Shuo Zhang, Jialing Shen, Don Wai-Ching Chin, Allen Zhang, Felice Ho-Ching Tsang, Ceci Lok-Sze Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge. Here, the authors show that phosphoglycerate dehydrogenase, a key enzyme in the serine synthe
Externí odkaz:
https://doaj.org/article/1f27ce98d13a42cd9355ac519e4b7c2f
Autor:
Don Wai Ching Chin, Vera Zhi Yuan Zheng, George K.C. Wong, Paul B.S. Lai, Hui Ma, Yi-Xiang J. Wang, Cindy See Wai Tong, Kevin Ka Wang Wang, Kin Ki Yan Lo, Ping Kuen Lam, Wai Sang Poon
Publikováno v:
Journal of Clinical Neuroscience. 71:226-233
In this study, the neuro-modulation effect of topical mesenchymal stem cells (MSCs) was tested in a rodent middle carotid artery occlusion (MCAO) model. Twenty-four hours after MCAO, craniotomy was made and 0.8 × 106 GFP-MSCs were topically applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22972c0da75d85d17063f4d24b61965e
https://doi.org/10.1016/j.jocn.2019.08.051
https://doi.org/10.1016/j.jocn.2019.08.051
Autor:
Cheuk-Ting Law, Jialing Shen, Carol Lai-Hung Cheng, Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Mengnuo Chen, Derek Lee, Lai Wei, Felice Hoi-Ching Tsang, Don Wai-Ching Chin, Chun-Ming Wong
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Epigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC) progression. Bromodomains are epigenetic “readers” of histone acetylation. Recently, bromodomain inhibitors have exhibited promising therapeutic potential for cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a988e91927adfae73ea64af4920719
http://europepmc.org/articles/PMC8292510
http://europepmc.org/articles/PMC8292510
Autor:
Don Wai-Ching Chin, Mengnuo Chen, Joyce Man-Fong Lee, Chun-Ming Wong, Derek Lee, Jialing Shen, Lai Wei, Irene Oi-Lin Ng, Cheuk-Ting Law, Carmen Chak-Lui Wong, Felice Ho-Ching Tsang, Carol Lai-Hung Cheng
Publikováno v:
Gut. 69:329-342
ObjectiveFacilitates Chromatin Transcription (FACT) complex is a histone chaperone participating in DNA repair-related and transcription-related chromatin dynamics. In this study, we investigated its oncogenic functions, underlying mechanisms and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c828c5522cf7df0bfcf4254c74d2785d
https://doi.org/10.1136/gutjnl-2019-318668
https://doi.org/10.1136/gutjnl-2019-318668
Autor:
Jialing Shen, Chunxue Yang, Misty Shuo Zhang, Don Wai-Ching Chin, For-Fan Chan, Cheuk-Ting Law, Gengchao Wang, Carol Lai-Hung Cheng, Mengnuo Chen, Rebecca Ting-Chi Wan, Mengjie Wu, Zhijian Kuang, Rakesh Sharma, Terence Kin Wah Lee, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong
Publikováno v:
Cell reports. 38(5)
Cancer cells adapt to hypoxia through HIFs (hypoxia-inducible factors), which initiate the transcription of numerous genes for cancer cell survival in the hypoxia microenvironment. In this study, we find that the FACT (facilitates chromatin transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5577d6932d58a02b104e076d341c8f3
https://pubmed.ncbi.nlm.nih.gov/35108543
https://pubmed.ncbi.nlm.nih.gov/35108543
Autor:
Don Wai-Ching Chin, Chun-Ming Wong, Vincent Wai-Hin Yuen, Scott W. Lowe, Siu-Ho Chok, David Kung-Chun Chiu, Iris Ming-Jing Xu, Tan To Cheung, Daniel For-Fan Chan, Carmen Chak-Lui Wong, Aki Pui-Wah Tse, Cerise Yuen-Ki Chan, Josef Leibold, Robin Kit-Ho Lai, Derek Lee, Irene Oi-Lin Ng, Macus Hao-Ran Bao
Publikováno v:
Hepatology
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancer worldwide which lacks effective treatment. Cancer cells experience high levels of oxidative stress due to increased generations of reactive oxygen species (ROS). Increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d153b30861e3d49fd2349a97524b8b6d
https://pubmed.ncbi.nlm.nih.gov/30561826
https://pubmed.ncbi.nlm.nih.gov/30561826
Autor:
Felice Ho-Ching Tsang, Don Wai-Ching Chin, Chun-Ming Wong, Carmen Chak-Lui Wong, Tsz-Ching Chloe Tang, Cheuk-Ting Law, Lai Wei, Irene Oi-Lin Ng, Wing-Sum Vincy Tam, Carol Lai-Hung Cheng
Publikováno v:
Hepatology (Baltimore, Md.). 69(6)
Hepatocellular carcinoma (HCC) cells exploit an aberrant transcriptional program to sustain their infinite growth and progression. Emerging evidence indicates that the continuous and robust transcription of oncogenes in cancer cells is often driven b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc685c8b5c142d072a35a17ec7a92ebd
https://pubmed.ncbi.nlm.nih.gov/30723918
https://pubmed.ncbi.nlm.nih.gov/30723918
Autor:
Cindy See Wai Tong, Don Wai Ching Chin, Anthony W.H. Chan, Andrew K Y Fung, Charing C N Chong, Yi-Xiang J. Wang, Richard Kwong Wai Choy, Kenneth Hoi Kin Wong, Ka Fai To, Anthony W.I. Lo, Ping Kuen Lam, Paul B.S. Lai
Publikováno v:
Transplantation Direct
Supplemental digital content is available in the text.
Background Ischemia-reperfusion injury (IRI) is commonly encountered after liver surgery. This study evaluated the hepatoprotective effects of topically applied adipose-derived mesenchymal s
Background Ischemia-reperfusion injury (IRI) is commonly encountered after liver surgery. This study evaluated the hepatoprotective effects of topically applied adipose-derived mesenchymal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea68b09871755b5957ddaea4481bd469
https://doi.org/10.1097/txd.0000000000000675
https://doi.org/10.1097/txd.0000000000000675