Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Don W. Coulter"'
Autor:
Anup S. Pathania, Haritha Chava, Nagendra K. Chaturvedi, Srinivas Chava, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-16 (2024)
Abstract Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature nerve cells, presenting significant treatment challenges due to therapy resistance. Despite intensive treatment, approximately 50% of high-risk NB cases
Externí odkaz:
https://doaj.org/article/226c2af1afc4471e87df8788cc1ced8c
Autor:
Philip Prathipati, Anup S. Pathania, Nagendra K. Chaturvedi, Subash C. Gupta, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 101543- (2024)
Neuroblastoma is the most devastating extracranial solid malignancy in children. Despite an intense treatment regimen, the prognosis for high-risk neuroblastoma patients remains poor, with less than 40% survival. So far, MYCN amplification status is
Externí odkaz:
https://doaj.org/article/7d9eb9261b3e4d0b860be7a5cf90ac13
Autor:
Don W. Coulter, Yashpal S. Chhonker, Devendra Kumar, Varun Kesherwani, Wafaa N. Aldhafiri, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Shantaram S. Joshi, Rongshi Li, Daryl J. Murry, Nagendra K. Chaturvedi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor prognoses and therapy resistance. However, MYC itself has been one of the most challenging targets for cancer treatment. Here,
Externí odkaz:
https://doaj.org/article/1f0fbd593c6a46b394d3ab29ce868b00
Publikováno v:
Cancers, Vol 15, Iss 24, p 5855 (2023)
MYC amplification or overexpression is most common in Group 3 medulloblastomas and is positively associated with poor clinical outcomes. Recently, protein arginine methyltransferase 5 (PRMT5) overexpression has been shown to be associated with tumori
Externí odkaz:
https://doaj.org/article/91d67df646b040b1a04b3b492c1f1f5f
Autor:
Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-driven MB. The bromodo
Externí odkaz:
https://doaj.org/article/74ff7cb36dd04e48ba6d2bd841e3e5f5
Autor:
Anup S. Pathania, Philip Prathipati, Omalla A. Olwenyi, Srinivas Chava, Oghenetejiri V. Smith, Subash C. Gupta, Nagendra K. Chaturvedi, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 308-329 (2022)
Neuroblastoma (NB) is an enigmatic and deadliest pediatric cancer to treat. The major obstacles to the effective immunotherapy treatments in NB are defective immune cells and the immune evasion tactics deployed by the tumor cells and the stromal micr
Externí odkaz:
https://doaj.org/article/bc3461424d0e4c1087e702fa93012a6c
Autor:
Kaitlin Fraser, Miriam Kuhn, Rebecca Swanson, Don W. Coulter, Christopher Copeland, Jorge M. Zuniga
Publikováno v:
Children, Vol 10, Iss 8, p 1287 (2023)
The main objective of this study was to describe the cortical patterns of brain activity during a gross dexterity task and develop a behavioral profile of children experiencing isolation. A cross-sectional assessment was conducted during one visit. S
Externí odkaz:
https://doaj.org/article/cc77377e715243c9b86c9d10529f68d9
Autor:
Matthew J. Kling, Connor N. Griggs, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in
Externí odkaz:
https://doaj.org/article/1e0bff91543c41f7aa95510776436cfe
Autor:
Kyle A. Rohrer, Heyu Song, Anum Akbar, Yingling Chen, Suravi Pramanik, Phillip J. Wilder, Erin M. McIntyre, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Don W. Coulter, Sutapa Ray
Publikováno v:
Cancers, Vol 15, Iss 8, p 2239 (2023)
MB is a common childhood malignancy of the central nervous system, with significant morbidity and mortality. Among the four molecular subgroups, MYC-amplified Group 3 MB is the most aggressive type and has the worst prognosis due to therapy resistanc
Externí odkaz:
https://doaj.org/article/812d33d1664a40b7ba084b6707bfdfc3
Autor:
Varun Kesherwani, Mamta Shukla, Don W. Coulter, J. Graham Sharp, Shantaram S. Joshi, Nagendra K. Chaturvedi
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background Medulloblastoma (MB) is one of the most common malignant cancers in children. MB is primarily classified into four subgroups based on molecular and clinical characteristics as (1) WNT (2) Sonic-hedgehog (SHH) (3) Group 3 (4) Group
Externí odkaz:
https://doaj.org/article/aebfab7e45d04559b079a0f1131a8fd5