Zobrazeno 1 - 10
of 433
pro vyhledávání: '"Don W Cleveland"'
Autor:
Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the t
Externí odkaz:
https://doaj.org/article/99efacbef7004ce6bd0c304590be3071
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS)
Externí odkaz:
https://doaj.org/article/95638d30dda343ee9bedd62a7544c554
Autor:
Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen
Publikováno v:
eLife, Vol 3 (2014)
The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centrome
Externí odkaz:
https://doaj.org/article/974d5ffd5ef4400b878f5e6af958c8c0
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106516- (2024)
Hyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 prote
Externí odkaz:
https://doaj.org/article/d52bed0e88e44065b4f372916bf8d8e0
Autor:
Michael P Hefferan, Jan Galik, Osamu Kakinohana, Gabriela Sekerkova, Camila Santucci, Silvia Marsala, Roman Navarro, Marian Hruska-Plochan, Karl Johe, Eva Feldman, Don W Cleveland, Martin Marsala
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42614 (2012)
Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimenta
Externí odkaz:
https://doaj.org/article/e8b98b01a9394c95af3b3e319e6e0d06
Autor:
Christine Vande Velde, Karli K McDonald, Yasmin Boukhedimi, Melissa McAlonis-Downes, Christian S Lobsiger, Samar Bel Hadj, Andre Zandona, Jean-Pierre Julien, Sameer B Shah, Don W Cleveland
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22031 (2011)
Mutations in superoxide dismutase (SOD1) are causative for inherited amyotrophic lateral sclerosis. A proportion of SOD1 mutant protein is misfolded onto the cytoplasmic face of mitochondria in one or more spinal cord cell types. By construction of m
Externí odkaz:
https://doaj.org/article/14f4e00cf1e547a98d384acdc5447147
Autor:
Alexander Samoshkin, Alexei Arnaoutov, Lars E T Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6831 (2009)
Condensins I and II in vertebrates are essential ATP-dependent complexes necessary for chromosome condensation in mitosis. Condensins depletion is known to perturb structure and function of centromeres, however the mechanism of this functional link r
Externí odkaz:
https://doaj.org/article/66fdcfa1740f4cf090bee580246d0dc0
Autor:
Yueming Chang, Qiongman Kong, Xiu Shan, Guilian Tian, Hristelina Ilieva, Don W Cleveland, Jeffrey D Rothstein, David R Borchelt, Philip C Wong, Chien-Liang Glenn Lin
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2849 (2008)
Accumulating evidence indicates that RNA oxidation is involved in a wide variety of neurological diseases and may be associated with neuronal deterioration during the process of neurodegeneration. However, previous studies were done in postmortem tis
Externí odkaz:
https://doaj.org/article/47b90d31b49b48ce8d3e00e9b55febff
Autor:
Nannette Jelluma, Arjan B Brenkman, Ian McLeod, John R Yates, Don W Cleveland, René H Medema, Geert J P L Kops
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2415 (2008)
BACKGROUND: Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN are weakened mitotic checkpoint signaling and persistent
Externí odkaz:
https://doaj.org/article/a85dd1c2764b4994aa7b4c8740159ff4