Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Don Souza"'
Autor:
Mary Sanville-Ross, Melissa Canfield, Gerhard Schaenzle, Bernd Guilliard, Eva Wex, Daniel Bischoff, Sylvia Blum, Don Souza, Andreas Schnapp, Mark Panzenbeck, Mohammed A. Kashem, Helena Obernolte, Oliver Radmacher, Della White, Georg Rast, Gerd-Michael Maier, Jennifer L Swantek, Olga Danov, Stefan lutz Wollin, Hannah Haas, Christine Strasser, Armin Braun, Katherina Sewald, Thierry Bouyssou, Klaus J. Erb, Takeshi Kono, Eva Thaler, Helga Nickel, Matthias Hoffmann, David J. Lamb
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 357(3)
BI 1002494 [(R)-4-{(R)-1-[7-(3,4,5-trimethoxy-phenyl)-[1,6]napthyridin-5-yloxy]-ethyl}pyrrolidin-2-one] is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with sustained plasma exposure after oral administration in rats, which q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14f89fa6cfeeec85a3fc0daa29eecf1
https://pubmed.ncbi.nlm.nih.gov/27048659
https://pubmed.ncbi.nlm.nih.gov/27048659
Autor:
Kerry L. M. Ralph, Mark Panzenbeck, Haiguang Xiao, Lee Frego, Tammy Bigwarfe, Erica Waltz, Christine Grimaldi, Kathy Last-Barney, Don Souza, Scott Brodeur, Gerald Nabozny, Jay S. Fine, Jorg H. W. Distler, Meera Ramanujam
Publikováno v:
The Journal of Immunology. 196:70.19-70.19
Targeting CD40-CD40L interactions has been an interesting drug concept for the treatment of autoimmune diseases given this pathway’s role in the development of both humoral and cell mediated immune responses. While preclinical blockade of CD40L is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a6c1ff851a90799154c339ba0d6cf8
https://doi.org/10.4049/jimmunol.196.supp.70.19
https://doi.org/10.4049/jimmunol.196.supp.70.19
Autor:
Angela Berry, Edward Pack, Gerald Nabozny, Alison Kukulka, Kirrane Thomas M, Daniel Kuzmich, Raj Betageri, Jörg Bentzien, Richard M. Nelson, Carol A. Torcellini, Bachir Latli, Christian Harcken, Mark Panzenbeck, Tazmeen N. Fadra, Roger M. Dinallo, Ljiljana Zuvela-Jelaska, Gilmore Thomas A, Don Souza, Heewon Lee, Josephine Pelletier, Younes Bekkali, Dieter Wiedenmayer, John R. Regan, Susan E. Goldrick, David S. Thomson
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(22)
We report a SAR of non-steroidal glucocorticoid mimetics that utilize indoles as A-ring mimetics. Detailed SAR is discussed with a focus on improving PR and MR selectivity, GR agonism, and in vitro dissociation profile. SAR analysis led to compound (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0894392651eead7a62f90ba3b953fd
https://pubmed.ncbi.nlm.nih.gov/21963986
https://pubmed.ncbi.nlm.nih.gov/21963986