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Autor:
James G Wall, Howard A Burris, Daniel D Von Hoff, Gladys Rodriguez, Rayna Kneuper-Hall, Don Shaffer, Timothy OʼRourke, Thomas Brown, Geoffrey Weiss, Gary Clark, Shirley McVea, Randall Johnson, Carl Friedman, Brian Smith, William S Mann, John Kuhn
Publikováno v:
Anti-cancer drugs. 3(4)
Topotecan (SKF 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I. An analog of camptothecin, topotecan was designed to be more water soluble in an effort to decrease the severe and