Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Don Richard Finley"'
Autor:
Don Richard Finley, Mark A. Winter, Daniel Jon Sall, Mark L. Heiman, Marlene L. Cohen, Christopher John Rito, Tania Miles, Anthony J. Shuker, William E. Bloomquist, Anthony G. Borel, Thomas W. Stephens, Michael Gregory Bell, Cynthia Darshini Jesudason, Aidas Kriauciunas, Donald P. Matthews, David Andrew Neel, Frank C. Tinsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafcd2d226d8437bcf2e7a738cbeb735
https://pubmed.ncbi.nlm.nih.gov/16931005
https://pubmed.ncbi.nlm.nih.gov/16931005
Autor:
Samuel W. Oldham, M. Joelle Dill, Brian Morgan Watson, Craig W. Lindsley, Don Richard Finley, Dana Sindelar, Lisa Selsam Beavers, Cynthia Darshini Jesudason, Philip Arthur Hipskind, Robert Alan Gadski, Ajay Singh, Christopher Stephen Siedem, Jeffrey W Cramer, R. Todd Pickard, F. Craig Stevens
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(13)
The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac411e9c4aa2b7b111ec41de2547f44
https://pubmed.ncbi.nlm.nih.gov/16677814
https://pubmed.ncbi.nlm.nih.gov/16677814
Autor:
Don Richard Finley, Andrew L. Glasebrook, Ellen R. Rowley, Lorri L. Short, Adrian, Martin Michael John, Magee David Edward, David Lynn Phillips, Lewis D. Pennington, Lugar Cw rd, Sung-Yong Stephen Cho, Mark A. Winter, Ken Matsumoto, Harlan W. Cole, Bryant Hu, Timothy Alan Grese, Charles David Jones, Godfrey Ag
Publikováno v:
Journal of medicinal chemistry. 40(2)
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. A series of raloxifene analogs which contain modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82509c0f3ab244dea00fd753c3fcecf
https://pubmed.ncbi.nlm.nih.gov/9003514
https://pubmed.ncbi.nlm.nih.gov/9003514
Publikováno v:
The Journal of Antibiotics. 32:1155-1160
The synthesis of the acetoxymethyl (AOM) ester of cefamandole (CM) is described. The sparingly soluble ester is shown to be well absorbed orally by mice, but only when administered in solution in a partially non-aqueous vehicle, 50% propylene glycol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4d9136cb91b3960a0d64777f5c1d2a
https://doi.org/10.7164/antibiotics.32.1155
https://doi.org/10.7164/antibiotics.32.1155
Publikováno v:
The Journal of Antibiotics. 39:1611-1614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64e67e8c93084a63652749291b9cdc6
https://doi.org/10.7164/antibiotics.39.1611
https://doi.org/10.7164/antibiotics.39.1611
Autor:
Harold E. Obsorne, Jack B. Deeter, Donn G. Wishka, John T. Ott, William J. Wheeler, R. E. Koehler, Michael Dean Kinnick, John K. Swartzendruber, Don Richard Finley
Publikováno v:
The Journal of Antibiotics. 39:111-120
A series of 7 beta-[2-(5-aminooxadiazol-3-yl)-2-Z-methoximinoacetamido] -3-cephem-4-carboxylic acids (7a-g) were synthesized and evaluated microbiologically Although somewhat less active than cefotaxime 7a-g showed good antimicrobial activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c22fcb2ec5d2b4d18de45cc95077859
https://doi.org/10.7164/antibiotics.39.111
https://doi.org/10.7164/antibiotics.39.111
Publikováno v:
The Journal of Antibiotics. 33:72-75
The preparation of crystalline bis-trimethylsilylcefamandole (7) and its utility in the preparation and purification of cefamandole are described. Although stable to solvolysis in isopropyl alcohol, 7 underwent smooth conversion to cefamandole in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24aa2005f1275ec85faf08562f972dd
https://doi.org/10.7164/antibiotics.33.72
https://doi.org/10.7164/antibiotics.33.72
Publikováno v:
The Journal of antibiotics. 39(1)
7 beta-[2-(2-Aminooxazol-4-yl)-2-Z-methoximinoacetamido]-3-cep hem -4-carboxylic acids 12 and 13 were synthesized. The microbiological activity of 12 and 13 as well as the beta-lactamase stability of 12 were discussed. Both 12 and 13 were quite activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd5ef743b4b7aef31c3fafec74a566f
https://pubmed.ncbi.nlm.nih.gov/3485088
https://pubmed.ncbi.nlm.nih.gov/3485088