Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Don R, Phillips"'
Autor:
Oula C. Mansour, Abraham Nudelman, Ada Rephaeli, Don R. Phillips, Suzanne M. Cutts, Benny J. Evison
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:773-784
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb5e36acd66c676857317f6b24b4a17
https://doi.org/10.1007/s00280-022-04435-1
https://doi.org/10.1007/s00280-022-04435-1
Autor:
Oula C, Mansour, Abraham, Nudelman, Ada, Rephaeli, Don R, Phillips, Suzanne M, Cutts, Benny J, Evison
Publikováno v:
Cancer chemotherapy and pharmacology. 89(6)
Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin's lymphoma. The drug is firmly established as a poison of the nuclear enzyme topoisomerase II, however, pixantrone can also generate covalent drug-DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::229458ca9d75d78a77adf2e3d6bb47df
https://pubmed.ncbi.nlm.nih.gov/35460360
https://pubmed.ncbi.nlm.nih.gov/35460360
Autor:
Keith G. Watson, Benny J. Evison, Brad E. Sleebs, Don R. Phillips, Jelena Medan, Suzanne M. Cutts, Kurt Lackovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking assays, electrophoretic gel shift assays, DNA and RNA stop assays, mass spectrometry-based methods and 32P-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae5ce5bb8656e0213c964940bc8181
https://pubmed.ncbi.nlm.nih.gov/33486050
https://pubmed.ncbi.nlm.nih.gov/33486050
Publikováno v:
BiopolymersREFERENCES. 112(4)
The application of artificial intelligence and machine learning to hyperspectral mass spectrometry imaging (MSI) data has received considerable attention over recent years. Various methodologies have shown great promise in their ability to handle the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a7266120bac4273be3d4691e2043b4
https://pubmed.ncbi.nlm.nih.gov/32937683
https://pubmed.ncbi.nlm.nih.gov/32937683
Autor:
Nataly Tarasenko, Suzanne M Cutts, Don R Phillips, Aida Inbal, Abraham Nudelman, Gania Kessler-Icekson, Ada Rephaeli
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31393 (2012)
The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) synergizes the cytotoxic effect of doxorubicin (Dox) and anti-HER2 on mammary carcinoma cells while protecting normal cells against their insults. This study investig
Externí odkaz:
https://doaj.org/article/dcc0d7c2dbf64f00a5e9eb8a6a71bb84
Autor:
Shyam K. Konda, Jelena Medan, J. Grant Collins, Paul P. Pumuye, Brad E. Sleebs, Suzanne M. Cutts, Celine Kelso, Don R. Phillips
Publikováno v:
Organic & Biomolecular Chemistry. 14:4728-4738
The ability of a bis-amino mitoxantrone anticancer drug (named WEHI-150) to form covalent adducts with DNA, after activation by formaldehyde, has been studied by electrospray ionisation mass spectrometry and HPLC. Mass spectrometry results showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bbbd7675d9bb8b11e5c6e8da5f8e96
https://doi.org/10.1039/c6ob00561f
https://doi.org/10.1039/c6ob00561f
Autor:
Brad E. Sleebs, Benny J. Evison, Paul P. Pumuye, Jelena Medan, Celine Kelso, Suzanne M. Cutts, Don R. Phillips, J. Grant Collins, Keith G. Watson, Shyam K. Konda
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115260
Mitoxantrone is an anticancer anthracenedione that can be activated by formaldehyde to generate covalent drug-DNA adducts. Despite their covalent nature, these DNA lesions are relatively labile. It was recently established that analogues of mitoxantr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff843e1e50e3195bb5a68e5e9272cf8e
https://doi.org/10.1016/j.bmc.2019.115260
https://doi.org/10.1016/j.bmc.2019.115260
Publikováno v:
Medicinal Research Reviews. 36:248-299
Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic profile of the anthracyclines and is commonly applied in the treatment of breast and prostate cancers, lymphomas, and leukemias. A comprehensive overview of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92dcdc4a4eb4bb12f893956e4606463b
https://doi.org/10.1002/med.21364
https://doi.org/10.1002/med.21364
Publikováno v:
ResearcherID
Doxorubicin has been in use as a key anticancer drug for forty years, either as a single agent or in combination chemotherapy. It functions primarily by interfering with topoisomerase II activity but in the presence of formaldehyde, it forms adducts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d7ad8e5246a1e5f26340894a21993
https://doi.org/10.2174/1568026615666150413154512
https://doi.org/10.2174/1568026615666150413154512
Autor:
Suzanne M. Cutts, Anthony I. Day, Alison Cheong, Lynne Wallace, Sean McGrath, Tina Robinson, Peter Lock, Don R. Phillips, Alex Spurling, Belinda S. Parker, Shyam K. Konda, Ruqaya Maliki, J. Grant Collins, Paul J. Pigram
Mitoxantrone was efficiently encapsulated within cucurbit[8]uril in a 2:1 complex where the two mitoxantrone molecules were symmetrically located through both portals of a cucurbit[8]uril cage. The novel complex facilitates increased mitoxantrone upt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fb5bf870310b26517cd4f97e943486
https://europepmc.org/articles/PMC5430389/
https://europepmc.org/articles/PMC5430389/
