Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Don Mason"'
Autor:
Don Mason
Publikováno v:
Immunological Reviews. 182:80-88
How the adaptive immune system achieves self-non-self discrimination is not well understood, and in this article consideration is given to some of the quantitative aspects of this problem. In particular, the modification of the T-cell repertoire as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369c28ea2603784bbd347a599d7b851a
https://doi.org/10.1034/j.1600-065x.2001.1820106.x
https://doi.org/10.1034/j.1600-065x.2001.1820106.x
Publikováno v:
European Journal of Immunology. 31:1247-1254
CD4(+)CD25(+) T cells in mice and rats are capable of transferring protection against organ-specific autoimmune disease and colitis and suppressing the proliferation of other T cells after polyclonal stimulation in vitro. Here we describe the existen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7baf1e3d326226764585ad5125bd574
https://doi.org/10.1002/1521-4141(200104)31:4<1247::aid-immu1247>3.0.co
https://doi.org/10.1002/1521-4141(200104)31:4<1247::aid-immu1247>3.0.co
Publikováno v:
Immunology. 101:178-184
Among peripheral T cells, the expression of CD4 and CD8 is almost mutually exclusive. However, here we show, using flow cytometric analysis, that ex vivo approximately 6% of rat T cells stained for both CD4 and CD8. These double positive cells were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67f9f7fa824a10011ba26e040caa4b2
https://doi.org/10.1046/j.1365-2567.2000.00071.x
https://doi.org/10.1046/j.1365-2567.2000.00071.x
Autor:
Don Mason, Leigh A. Stephens
Publikováno v:
The Journal of Immunology. 165:3105-3110
Previously we have shown that autoimmune diabetes, induced in rats by a protocol of adult thymectomy and split-dose gamma irradiation, can be prevented by the transfer of a subset of CD4+ T cells with a memory phenotype (CD45RC−), as well as by CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1375d3cc5fc75b57c824c4643cea71c3
https://doi.org/10.4049/jimmunol.165.6.3105
https://doi.org/10.4049/jimmunol.165.6.3105
Autor:
Francisco Ramirez, Don Mason
Publikováno v:
The Journal of Immunology. 165:1816-1823
CD4+ T cell subsets are unequally distributed in rat secondary lymphoid organs. Those with the memory phenotype CD45RClow Thy-1− L-selectin− are present at a higher frequency in Peyer’s patches (PP) than in lymph nodes and spleen, and increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4710c2cd60ec835758c4c705a2ab7187
https://doi.org/10.4049/jimmunol.165.4.1816
https://doi.org/10.4049/jimmunol.165.4.1816
Autor:
Francisco Ramirez, Don Mason
Publikováno v:
European Journal of Immunology. 30:747-758
We have produced T cell lines with a Th2 phenotype in the presence of IL-4 and the glucocorticoid dexamethasone (DEX). IL-4 and DEX together were more effective in inducing a Th2 response than IL-4 alone. Myelin basic protein (MBP)-specific Th2 lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504fa7746d3e5e35ef22435cb346b220
https://doi.org/10.1002/1521-4141(200003)30:3<747::aid-immu747>3.0.co
https://doi.org/10.1002/1521-4141(200003)30:3<747::aid-immu747>3.0.co
Publikováno v:
Diabetes. 48:2157-2165
Two rodent models of autoimmune type 1 diabetes have been used to investigate the role of insulin as an autoantigen in this disease. In lymphopoenia-induced diabetes in the PVG.RT1u rat, neonatal tolerization with insulin B-chain peptides, but not A-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752dfc9a8e51a03881b9c39d07532fc7
https://doi.org/10.2337/diabetes.48.11.2157
https://doi.org/10.2337/diabetes.48.11.2157
Publikováno v:
Journal of Immunological Methods. 221:141-150
The present article describes procedures to measure rat IL-4 protein. The RT-PCR technique has been successfully and widely used to measure IL-4 mRNA, but it does not determine IL-4 protein synthesis. Assays to measure rat IL-4 protein based on its b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b358c656141c0aadbb4e3c6511435d9b
https://doi.org/10.1016/s0022-1759(98)00176-8
https://doi.org/10.1016/s0022-1759(98)00176-8
Autor:
Don Mason
Publikováno v:
Immunology Today. 19:395-404
It is commonly accepted that a high level of antigen specificity is a feature of T-cell activation. However, here, Don Mason argues that a comprehensive response to foreign antigens requires that T cells are widely crossreactive, such that one cell r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6093bf82860e2301fd59be96a27570a8
https://doi.org/10.1016/s0167-5699(98)01299-7
https://doi.org/10.1016/s0167-5699(98)01299-7
Publikováno v:
Seminars in Immunology. 9:375-380
The data in this article challenge the current paradigm that self tolerance among T cells can be fully accounted for in terms of intrathymic clonal deletion, anergy and T-cell ‘indifference’. We show that autoreactive T cells are under the contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e959c3bcd55ef7d4b01255aef7be0544
https://doi.org/10.1006/smim.1997.0095
https://doi.org/10.1006/smim.1997.0095