Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Autor: Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. de Vries, Jai G. Broome, James P. Pirruccello, Michael C. Honigberg, Krishna Aragam, Brooke Wolford, Jennifer A. Brody, Lucinda Antonacci-Fulton, Moscati Arden, Stella Aslibekyan, Themistocles L. Assimes, Christie M. Ballantyne, Lawrence F. Bielak, Joshua C. Bis, Brian E. Cade, Ron Do, Harsha Doddapaneni, Leslie S. Emery, Yi-Jen Hung, Marguerite R. Irvin, Alyna T. Khan, Leslie Lange, Jiwon Lee, Rozenn N. Lemaitre, Lisa W. Martin, Ginger Metcalf, May E. Montasser, Jee-Young Moon, Donna Muzny, Jeffrey R. O’Connell, Nicholette D. Palmer, Juan M. Peralta, Patricia A. Peyser, Adrienne M. Stilp, Michael Tsai, Fei Fei Wang, Daniel E. Weeks, Lisa R. Yanek, James G. Wilson, Goncalo Abecasis, Donna K. Arnett, Lewis C. Becker, John Blangero, Eric Boerwinkle, Donald W. Bowden, Yi-Cheng Chang, Yii-Der I. Chen, Won Jung Choi, Adolfo Correa, Joanne E. Curran, Mark J. Daly, Susan K. Dutcher, Patrick T. Ellinor, Myriam Fornage, Barry I. Freedman, Stacey Gabriel, Soren Germer, Richard A. Gibbs, Jiang He, Kristian Hveem, Gail P. Jarvik, Robert C. Kaplan, Sharon L. R. Kardia, Eimear Kenny, Ryan W. Kim, Charles Kooperberg, Cathy C. Laurie, Seonwook Lee, Don M. Lloyd-Jones, Ruth J. F. Loos, Steven A. Lubitz, Rasika A. Mathias, Karine A. Viaud Martinez, Stephen T. McGarvey, Braxton D. Mitchell, Deborah A. Nickerson, Kari E. North, Aarno Palotie, Cheol Joo Park, Bruce M. Psaty, D. C. Rao, Susan Redline, Alexander P. Reiner, Daekwan Seo, Jeong-Sun Seo, Albert V. Smith, Russell P. Tracy, Ramachandran S. Vasan, Sekar Kathiresan, L. Adrienne Cupples, Jerome I. Rotter, Alanna C. Morrison, Stephen S. Rich, Samuli Ripatti, Cristen Willer, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, FinnGen, Gina M. Peloso

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the

Externí odkaz: https://doaj.org/article/09cb57a2d8544b5e803b374995f412e4

Abstract 042: Trends In Hypertensive Disorders Of Pregnancy Among Nulliparous Individuals With Singleton Live Births In The United States: An Age-period-cohort Analysis Between 1995-2019

Autor: Natalie A Cameron, Lucia Petito, Nilay Shah, Amanda M Perak, Janet M Catov, Natalie A Bello, Simon CAPEWELL, Martin E Oflaherty, Don M Lloyd-jones, Philip Greenland, William GROBMAN, Sadiya Khan

Publikováno v: Circulation. 145

Introduction: Incidence of hypertensive disorders of pregnancy (HDP) has increased concurrently with maternal age at first birth. To better understand the contributions of age, delivery year (period), and maternal birth year (birth cohort) to HDP rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3bbad8c2c92c24a1b3efbb74927e81d
https://doi.org/10.1161/circ.145.suppl_1.042

Abstract 12810: Data-Driven Clusters of Cardiac Structure and Function and Association With Premature Cardiovascular Disease: The Coronary Artery Disease in Young Adults (CARDIA) Study

Autor: Michael C Wang, Lindsay R Pool, Norrina B Allen, Paul A Reyfman, Yuan Luo, Joao A Lima, Don M Lloyd-jones, Sadiya S Khan

Publikováno v: Circulation. 144

Introduction: Abnormal indices of cardiac structure and function likely cluster together. However, the clinical relevance of data-driven patterns of cardiac remodeling across a broad range of echocardiographic measures, particularly in mid-life, is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a17125dc400b76aa54b3e5dddc2641fc
https://doi.org/10.1161/circ.144.suppl_1.12810