Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Don L Siegel"'
Autor:
Denarda Dangaj, Karen L Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S Kirby, Raphael Sandaltzopoulos, Daniel J Powell, Antonin Lamazière, Don L Siegel, Claude Wolf, Nathalie Scholler
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28386 (2011)
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and C
Externí odkaz:
https://doaj.org/article/a34c0064476e43049f7bf1b7cab6706f
Autor:
Sho Yoshimoto, Nicholas Chester, Ailian Xiong, Enrico Radaelli, Hong Wang, Marc Brillantes, Gayathri Gulendran, Patrick Glassman, Don L. Siegel, Nicola J. Mason
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTPD-1 checkpoint inhibitors have revolutionized the treatment of patients with different cancer histologies including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients show a dramatic clinica
Externí odkaz:
https://doaj.org/article/e2cc3ba3c4cc456f979a67ebfed7ed7f
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Autor:
Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 387-398 (2021)
Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modifi
Externí odkaz:
https://doaj.org/article/21295495ac0b4d158ff8bf09829bb9f3
Autor:
Hyeree Choi, Sagar B. Kudchodkar, Emma L. Reuschel, Kanika Asija, Piyush Borole, Sangya Agarwal, Lucas Van Gorder, Charles C. Reed, Gayathri Gulendran, Stephanie Ramos, Kate E. Broderick, J Joseph Kim, Kenneth E. Ugen, Gary Kobinger, Don L. Siegel, David B. Weiner, Kar Muthumani
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 4, Pp 907-918 (2020)
Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been an increase in cases of the devastating birth defect microcephaly as well as of Guillain–B
Externí odkaz:
https://doaj.org/article/4c5462e0a3344f308a609dd19930347f
Autor:
Alfred L. Garfall, Ehren K. Dancy, Adam D. Cohen, Wei-Ting Hwang, Joseph A. Fraietta, Megan M. Davis, Bruce L. Levine, Don L. Siegel, Edward A. Stadtmauer, Dan T. Vogl, Adam Waxman, Aaron P. Rapoport, Michael C. Milone, Carl H. June, J. Joseph Melenhorst
Publikováno v:
Blood Advances, Vol 3, Iss 19, Pp 2812-2815 (2019)
Externí odkaz:
https://doaj.org/article/c2b1211d1c304b2d96f08de44dae0f46
Autor:
Ying-Chao Hsueh, Yuzhen Wang, Rebecca L. Riding, Donna E. Catalano, Yu-Jung Lu, Jillian M. Richmond, Don L. Siegel, Mary Rusckowski, John R. Stanley, John E. Harris
Publikováno v:
Journal of Investigative Dermatology. 142:3294-3303
Despite the central role of IFN-γ in vitiligo pathogenesis, systemic IFN-γ neutralization is an impractical treatment option owing to strong immunosuppression. However, most patients with vitiligo present with20% affected body surface area, which p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e65e4630f900bc1b7f97aea5a802c85
https://doi.org/10.1016/j.jid.2022.06.007
https://doi.org/10.1016/j.jid.2022.06.007
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Alfred L. Garfall, Adam D. Cohen, Sandra P. Susanibar-Adaniya, Wei-Ting Hwang, Dan T. Vogl, Adam J. Waxman, Simon F. Lacey, Vanessa E. Gonzalez, Joseph A. Fraietta, Minnal Gupta, Irina Kulikovskaya, Lifeng Tian, Fang Chen, Natalka Koterba, Robert L. Bartoszek, Margaret Patchin, Rong Xu, Gabriela Plesa, Don L. Siegel, Andrea Brennan, Anne Marie Nelson, Regina Ferthio, Angela Cosey, Kim-Marie Shea, Rachel Leskowitz, Megan Four, Wesley V. Wilson, Fei Miao, Eric Lancaster, Beatriz M. Carreno, Gerald P. Linette, Elizabeth O. Hexner, Regina M. Young, Dexiu Bu, Keith G. Mansfield, Jennifer L. Brogdon, Carl H. June, Michael C. Milone, Edward A. Stadtmauer
Publikováno v:
Blood Cancer Discovery. 4:118-133
We conducted a phase I clinical trial of anti-BCMA chimeric antigen receptor T cells (CART-BCMA) with or without anti-CD19 CAR T cells (huCART19) in multiple myeloma (MM) patients responding to third- or later-line therapy (phase A, N = 10) or high-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af15a4e58dc3d2eade0573800002170e
https://doi.org/10.1158/2643-3230.bcd-22-0074
https://doi.org/10.1158/2643-3230.bcd-22-0074
Autor:
Andrew D. Fesnak, Don L. Siegel
Publikováno v:
Rossi's Principles of Transfusion Medicine. :633-641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c6a607a05cd1968f3e37f728b31630
https://doi.org/10.1002/9781119719809.ch55
https://doi.org/10.1002/9781119719809.ch55
Autor:
Connie M. Westhoff, Don L. Siegel
Publikováno v:
Rossi's Principles of Transfusion Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a6ad24ef1beb5bd64799f5b86e4887
https://doi.org/10.1002/9781119719809.ch10
https://doi.org/10.1002/9781119719809.ch10