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Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family
Autor:
Ye Wu, Nathan D Lakey, Thomas Brody, Karen J. Moore, Janice A. Culpepper, George A. Carlson, Lisa Holmgren, Geoffrey D Alperin, John Lee, Patrick W. Kleyn, Jim Deeds, Elizabeth A. Woolf, Don J Misumi, Lucy R Berkemeier, Olga Tayber, Chris Ebeling, Linda Baldini, Olga Charlat, Jacqueline C. Pulido, Pei Shu, M.Alexandra Glücksmann-Kuis, Geoffrey M. Duyk, Steve G. Kovats, Brenda Kennedy, Fiona Hawkins, Hong Chen, Wei Fan
Publikováno v:
Cell. (2):281-290
The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The conse