Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Don Hong Wang"'
Autor:
Bryan M. Burt, Edgar Engleman, Farrah Kheradmand, David J. Sugarbaker, Thomas M. Wheeler, Gerald Berry, David Yoon, Hyun-Sung Lee, Don-Hong Wang
Purpose: Lung adenocarcinomas with mutations in the EGFR have unprecedented initial responses to targeted therapy against the EGFR. Over time, however, these tumors invariably develop resistance to these drugs. We set out to investigate alternative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b259ba406e54c96bae2b42628d0437
https://doi.org/10.1158/1078-0432.c.6523299.v1
https://doi.org/10.1158/1078-0432.c.6523299.v1
Autor:
Bryan M. Burt, Edgar Engleman, Farrah Kheradmand, David J. Sugarbaker, Thomas M. Wheeler, Gerald Berry, David Yoon, Hyun-Sung Lee, Don-Hong Wang
(A) Flow cytometry was used to determine the expression of human EGFR on AM and CD45- cells within single cell suspensions of lung cells from bitransgenic mice fed dox for 7 weeks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336d19a9160ab5d16bac29f3e52ccb80
https://doi.org/10.1158/1078-0432.22456407
https://doi.org/10.1158/1078-0432.22456407
Autor:
Bryan M. Burt, Edgar Engleman, Farrah Kheradmand, David J. Sugarbaker, Thomas M. Wheeler, Gerald Berry, David Yoon, Hyun-Sung Lee, Don-Hong Wang
Bitransgenic mice were fed dox for 7 weeks and treated with a depleting antibody against CSF-1R every other day. Expression of MHC-II and CD40 were evaluated by flow cytometry (A) and tumor burden was evaluated by H-E staining on lung tissue sections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dd85f15e80e48085423d9bac7a337a
https://doi.org/10.1158/1078-0432.22456404.v1
https://doi.org/10.1158/1078-0432.22456404.v1
Autor:
Bryan M. Burt, Edgar Engleman, Farrah Kheradmand, David J. Sugarbaker, Thomas M. Wheeler, Gerald Berry, David Yoon, Hyun-Sung Lee, Don-Hong Wang
CD45-humanEGFR+ cells were sorted from the lungs of bitransgenic mice fed dox for 7 weeks and cultured for 24 hours in the presence of empty liposomes or clodronate-liposomes. Flow cytometry was used to evaluate cell death (DAPI) and apoptosis (Annex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4368d68775897c6d38691016928b8652
https://doi.org/10.1158/1078-0432.22456401
https://doi.org/10.1158/1078-0432.22456401
Autor:
Yoshihiro Izumiya, Keisuke Kobayashi, Kevin Y Kim, Mamata Pochampalli, Chie Izumiya, Bogdan Shevchenko, Don-Hong Wang, Steve B Huerta, Anthony Martinez, Mel Campbell, Hsing-Jien Kung
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003506 (2013)
The small ubiquitin-like modifier (SUMO) is a protein that regulates a wide variety of cellular processes by covalent attachment of SUMO moieties to a diverse array of target proteins. Sumoylation also plays an important role in the replication of ma
Externí odkaz:
https://doaj.org/article/f2099a97d1774c93a822916574ce05dc
Autor:
Brittany Weems, Carolina F. Reis, Hsing Jien Kung, Brianna Ribeiro, Xiaobing Wang, Don Hong Wang, Chao Yu Chen, Daniel H. Enter, Sara Ahadi, Seth Dixon, Liping Meng, Laura M. Ramirez, Leonardo J. Leon, Jason Kato, Yoshiko Maeda, Kit S. Lam, Chun Yi Wu
Publikováno v:
ACS combinatorial science, vol 18, iss 6
ACS Combinatorial Science
ACS Combinatorial Science
Identifying "druggable" targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f338b85dbbee4a5c01e2929ce5b1b6ef
https://doi.org/10.1021/acscombsci.5b00194
https://doi.org/10.1021/acscombsci.5b00194
Autor:
Mengxi Tian, Alyssa Mullenix, Rishi Savur, Sravani Mangalampalli, Alba Gonzalez, Rowena Martinez, Timothy K. Lu, Dharini Iyer, Chen-Ting Lee, Russell Morrison Gordley, Anissa Benabbas, Don Hong Wang, Archana S. Nagaraja, Christina J. Huynh, Allison Quach, Philip Janmin Lee, Frances D. Liu, Ashita Magal, Carmina C. Blanco, Brian S. Garrison, Daniel O. Frimannsson, Gary Lee, Tiffany A. Truong, Jack T. Lin, Alyssa Perry-McNamara, Ori Maller
Publikováno v:
Cancer Research. 80:4246-4246
While immunotherapies based on single recombinant cytokines such as IL12 and IL21 have shown great promise in preclinical models of solid tumors, clinical translation has proven challenging due to limited mechanisms of action, narrow therapeutic wind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825bed715be764544b102da3cc66a8db
https://doi.org/10.1158/1538-7445.am2020-4246
https://doi.org/10.1158/1538-7445.am2020-4246
Autor:
Bogdan Shevchenko, Mel Campbell, Chie Izumiya, Don Hong Wang, Steve B. Huerta, Kevin Y. Kim, Yoshihiro Izumiya
Publikováno v:
Molecular and cellular biology, vol 35, iss 1
The retinoblastoma protein (pRb/p105) tumor suppressor plays a pivotal role in cell cycle regulation by blockage of the G1-to-S-phase transition. pRb tumor suppressor activity is governed by a variety of posttranslational modifications, most notably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb438f74aaef9397674e845b0f1d3658
https://doi.org/10.1128/mcb.00945-14
https://doi.org/10.1128/mcb.00945-14
Autor:
Don Hong Wang, Steve B. Huerta, Yoshihiro Izumiya, Chie Izumiya, Pei Ching Chang, Bogdan Shevchenko, Kevin Y. Kim, Hsing Jien Kung, Mel Campbell
Publikováno v:
Journal of virology, vol 88, iss 3
Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fb3af2b56e4afad3b4502e3667a3f5
https://doi.org/10.1128/jvi.03251-13
https://doi.org/10.1128/jvi.03251-13
Autor:
Mel Campbell, Steve B. Huerta, Chie Izumiya, Hsing Jien Kung, Anthony Martinez, Bogdan Shevchenko, Don Hong Wang, Kevin Y. Kim, Yoshihiro Izumiya
Publikováno v:
Journal of Virology. 87:6782-6793
Kaposi's sarcoma-associated herpesvirus (KSHV) latent genomes are tethered to host histones to form a minichromosome also known as an “episome.” Histones, which are core components of chromatin, are heavily modified by various histone-targeting e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bf99f8854606519188121678b5935f
https://doi.org/10.1128/jvi.00011-13
https://doi.org/10.1128/jvi.00011-13