Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Don G. Lee"'
Autor:
Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh, Sunhee Hwang, Yu I. Kim, Sang H. Park, Kwang H. Kim, Don G. Lee, Ho S. Oh, Sangeun Lee, Young H. Kim, Beom K. Choi, Byoung S. Kwon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR
Externí odkaz:
https://doaj.org/article/2cb448a0b80d4a85bfbe75a3ddee2e23
Autor:
Eun M. Yu, Eunjung Cho, Rohit Singh, Seon-Hee Kim, Chungyong Han, Seongeun Han, Don G. Lee, Young H. Kim, Byoung S. Kwon, Beom K. Choi
Publikováno v:
Cells, Vol 10, Iss 8, p 2018 (2021)
Adoptive cell therapy (ACT) using tumor-reactive T cells is a promising form of immunotherapy to specifically target cancer. However, the survival and functional maintenance of adoptively transferred T cells remains a challenge, ultimately limiting t
Externí odkaz:
https://doaj.org/article/f64211fdb8e54a23963b4600aa11a84b
Autor:
Don G. Lee, Sang Soo Kim, Dong Hoon Shin, Seon Hee Kim, Eunjung Cho, Hyeon-Woo Lee, Byoung S. Kwon, Beom K. Choi, Hye Jin You, Rohit Singh, Young Ho Kim, Chungyong Han, Yu I. Kim
Publikováno v:
Cellular and Molecular Immunology
The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their clinical development. Here, we aimed to stud
Autor:
Young Ho Kim, Rohit Singh, Seon Hee Kim, Beom K. Choi, Eun Mi Yu, Eunjung Cho, Seongeun Han, Don G. Lee, Chungyong Han, Byoung S. Kwon
Publikováno v:
Cells, Vol 10, Iss 2018, p 2018 (2021)
Cells
Volume 10
Issue 8
Cells
Volume 10
Issue 8
Adoptive cell therapy (ACT) using tumor-reactive T cells is a promising form of immunotherapy to specifically target cancer. However, the survival and functional maintenance of adoptively transferred T cells remains a challenge, ultimately limiting t
Autor:
Ho S Oh, Beom K Choi, Young H Kim, Don G Lee, Sunhee Hwang, Myoung J Lee, Sang H Park, Yong-Soo Bae, Byoung S Kwon
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126765 (2015)
4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily (TNFRSF), is primarily expressed on activated T cells and is known to enhance proliferation of T cells, prevent activation-induced cell death, and promote memory formation of C
Externí odkaz:
https://doaj.org/article/c69734f1d70240f58f4859086a7ab231
Autor:
Beom K. Choi, Yu I. Kim, Ho Lee, Byoung S. Kwon, Chungyong Han, Seon Hee Kim, Ho S. Oh, Don G. Lee, Yoon Hee Jeon, Young Ho Kim
Publikováno v:
European Journal of Immunology. 48:1739-1749
RELT (tumor necrosis factor receptor superfamily member 19-like, TNFRSF19L) is a TNFR superfamily member that is primarily expressed in immune cells and lymphoid tissues, but whose immunological function is not well-defined. Here, we show that RELT i
Autor:
Beom K. Choi, Chungyong Han, Don G. Lee, Young Ho Kim, Ho S. Oh, Byoung S. Kwon, Kwang H. Kim
Publikováno v:
Autophagy. 12:1647-1659
VSIG4/CRIg (V-set and immunoglobulin domain containing 4) is a transmembrane receptor of the immunoglobulin superfamily that is expressed specifically on macrophages and mature dendritic cells. VSIG4 signaling accelerates phagocytosis of C3-opsonized
Autor:
Young Ho Kim, Chungyong Han, Byoung S. Kwon, Ho S. Oh, Don G. Lee, Beom K. Choi, Do Yun Lee, Seon Hee Kim
Publikováno v:
Cellular & Molecular Immunology. 14:748-757
4-1BB (CD137) is a strong enhancer of the proliferation of CD8+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabo
Autor:
Don G. Lee, Su M. Shin, Sang H. Park, Young Ho Kim, Seung Jin Lee, Ho S. Oh, Chang H. Kim, Beom K. Choi, Byoung S. Kwon, Kwang Hyun Kim
Publikováno v:
The Journal of Immunology. 195:4721-4729
The glucocorticoid-induced TNFR family–related protein (GITR, TNFRSF18, CD357) is expressed on effector and regulatory T (Treg) cells. Previous studies demonstrated that GITR triggering by anti-GITR mAb enhanced T and B cell–mediated immune respo
Autor:
Young Ho Kim, Sunhee Hwang, Rohit Singh, Yu I. Kim, Don G. Lee, Beom K. Choi, Byoung S. Kwon, Kwang Hyun Kim, Su-Jung Sim, Sang Eun Lee, Seonhee Kim, Ho S. Oh, Chungyong Han, Sang H. Park
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which are highly expressed on malignant cells but not on T cells. However, when T cells are enginee