Zobrazeno 1 - 10
of 904
pro vyhledávání: '"Don D, Sin"'
Autor:
Won-Dong Kim, Don D. Sin
Publikováno v:
COPD, Vol 21, Iss 1, Pp 1-11 (2024)
AbstractChronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different t
Externí odkaz:
https://doaj.org/article/a73fc2ca4d1947a69109af353104d22a
Autor:
Bryan R. Gorman, Sun-Gou Ji, Michael Francis, Anoop K. Sendamarai, Yunling Shi, Poornima Devineni, Uma Saxena, Elizabeth Partan, Andrea K. DeVito, Jinyoung Byun, Younghun Han, Xiangjun Xiao, Don D. Sin, Wim Timens, Jennifer Moser, Sumitra Muralidhar, Rachel Ramoni, Rayjean J. Hung, James D. McKay, Yohan Bossé, Ryan Sun, Christopher I. Amos, VA Million Veteran Program, Saiju Pyarajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remain
Externí odkaz:
https://doaj.org/article/dac86f32ac504f5bbdb7376d6931934e
Autor:
Don D. Sin
Publikováno v:
Tuberculosis and Respiratory Diseases, Vol 87, Iss 3, Pp 252-260 (2024)
Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endophenotypes, each driven by specific molecular networks and processe
Externí odkaz:
https://doaj.org/article/ac34dd71f099437b982825576b88da93
Autor:
Matthew Moll, Julian Hecker, John Platig, Jingzhou Zhang, Auyon J. Ghosh, Katherine A. Pratte, Rui-Sheng Wang, Davin Hill, Iain R. Konigsberg, Joe W. Chiles, III, Craig P. Hersh, Peter J. Castaldi, Kimberly Glass, Jennifer G. Dy, Don D. Sin, Ruth Tal-Singer, Majd Mouded, Stephen I. Rennard, Gary P. Anderson, Gregory L. Kinney, Russell P. Bowler, Jeffrey L. Curtis, Merry-Lynn McDonald, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105429- (2024)
Summary: Background: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using genetics (polygenic risk score
Externí odkaz:
https://doaj.org/article/a0549eb45ebc4c8e9d1d5f0c4da19d8b
Autor:
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that th
Externí odkaz:
https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048
Autor:
Firoozeh V Gerayeli, Stephen Milne, Chen Xi Yang, Xuan Li, Elizabeth Guinto, Julia Shun-Wei Yang, Chung Yan Cheung, Tara R Stach, Tawimas Shaipanich, Janice M Leung, Don D Sin
Publikováno v:
BioTechniques, Vol 75, Iss 4, Pp 157-167 (2023)
Single-cell RNA sequencing (scRNA-seq) is an important tool for understanding disease pathophysiology, including airway diseases. Currently, the majority of scRNA-seq studies in airway diseases have used invasive methods (airway biopsy, surgical rese
Externí odkaz:
https://doaj.org/article/b9df64f2258148a0955035cd9a90b316
Autor:
Don D. Sin
Publikováno v:
Tuberculosis and Respiratory Diseases, Vol 86, Iss 3, Pp 166-175 (2023)
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the micro
Externí odkaz:
https://doaj.org/article/b71102078eb14ea1ae8af95b01ac188c
Autor:
Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptom
Externí odkaz:
https://doaj.org/article/3bbc99c6afb9461b8675959190300c9f
Autor:
Don D. Sin
Publikováno v:
Tuberculosis and Respiratory Diseases, Vol 86, Iss 2, Pp 71-81 (2023)
Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide. COPD is characterized by significant airflow limitation on spirometry. Most patients with COPD are diagnosed in their fifth or sixth decades of life. However,
Externí odkaz:
https://doaj.org/article/14dfd33af6054f44af92d35a51b0abb4
Autor:
Ana I. Hernandez Cordero, Xuan Li, Julia Yang, Chen Xi Yang, Tawimas Shaipanich, Julie L. MacIsaac, Kristy Dever, Michael S. Kobor, Julio Montaner, Marianne Harris, Silvia Guillemi, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1261 (2024)
Background: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced ep
Externí odkaz:
https://doaj.org/article/f701d3d267eb4a0f96bcf938a909d574