Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Don Costa"'
Autor:
Deirdre Murphy, Sudarshan Kapadnis, Bryce Alden Harrison, Hilliary E Van Voorhies, Jean-Francois Blain, Emily A. Freeman, Jeffrey S. Moffit, Scott Nolan, Melody Wen, Lori Hrdlicka, Duane A. Burnett, Matthew Gregory Bursavich, Gerhard Koenig, Don Costa, Holger Patzke, Raksha A. Acharya, Cuyue Tang, Hong Jin
Publikováno v:
Journal of medicinal chemistry. 64(19)
The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f9b0147cc5066edcb7f9badfeea7b3
https://pubmed.ncbi.nlm.nih.gov/34550687
https://pubmed.ncbi.nlm.nih.gov/34550687
Autor:
Holger Patzke, Cuyue Tang, Gerhard Koenig, Hong Jin, Lori Hrdlicka, Duane A. Burnett, Sudarshan Kapadnis, Don Costa, Hilliary Hodgdon, Emily A. Freeman, Jean-Francois Blain, Jeffrey S. Moffit, Melody Wen, Bryce Alden Harrison, Matthew Gregory Bursavich, Raksha A. Acharya, Deirdre A. Murphy, Scott Nolan
Publikováno v:
Journal of medicinal chemistry. 60(6)
Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9482321eb4d1ebfec5e8c96be975c48
https://pubmed.ncbi.nlm.nih.gov/28230986
https://pubmed.ncbi.nlm.nih.gov/28230986
Autor:
Deirdre Murphy, Ting Chen, Dorothy G. Flood, Gerhard Koenig, Devin Franklin Welty, Yi Tao, Xing Chen, Scott Nolan, Sudarshan Kapadnis, Don Costa, Melody Wen, Hilliary Hodgdon, Cuyue Tang
Publikováno v:
Biochemical Pharmacology. 91:543-551
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa77931e039a2c0a620ef685b98b22f
https://doi.org/10.1016/j.bcp.2014.07.023
https://doi.org/10.1016/j.bcp.2014.07.023
Publikováno v:
American Journal of Nephrology. 30:521-526
Background/Aims: Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A1 receptors (A1Rs). We studied the effect of the orally active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9811194416c5ce0e138cb0b0bffabc3a
https://doi.org/10.1159/000248762
https://doi.org/10.1159/000248762
Autor:
Winnie Lee, Gerhard Koenig, Mary Jo Miller, Zhiyong Yang, Hilliary Hodgdon, Daniel Havas, Emily A. Freeman, Veerle Vulsteke, Holger Patzke, Liza Leventhal, Richard Chesworth, Sarah C. Hopp, Faris Albayya, Jean Francois Blain, Zhiming Tu, Michael K. Ahlijanian, Lori Hrdlicka, Louise Scrocchi, Scott Nolan, Melody Wen, Henrik Zetterberg, Dorothy G. Flood, Don Costa, Kevin M. Felsenstein, Erik Portelius, Kathryn Rogers, Gideon Shapiro, Birgit Hutter-Paier, Bart De Strooper, Darcie Spaulding
Publikováno v:
Molecular Neurodegeneration, Vol 7, Iss 1, p 61 (2012)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background A hallmark of Alzheimer’s disease is the presence of senile plaques in human brain primarily containing the amyloid peptides Aβ42 and Aβ40. Many drug discovery efforts have focused on decreasing the production of Aβ42 through γ-secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a88ecbc048653eaeb4fe42e5c0f15
http://www.molecularneurodegeneration.com/content/7/1/61
http://www.molecularneurodegeneration.com/content/7/1/61
Autor:
Ricardo Ramirez, Tom Koperniak, Hilliary Hodgdon, Don Costa, Kathryn Rogers, Emily A. Freeman, Gerhard Koenig, Irena Lovric, Zhiyong Yang, Dorothy G. Flood, Angela Chen, Holger Patzke, Liza Leventhal, Darcie Spaulding, Jean-Francois Blain, Rachelle Driscoll
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f80a809429542fc12ffaeafb22ffa6
https://doi.org/10.1016/j.jalz.2012.05.498
https://doi.org/10.1016/j.jalz.2012.05.498
Autor:
Florentina Catana, Michael K. Ahlijanian, Gerhard Koenig, Thomas Koperniak, Don Costa, Kathryn Rogers, Liza Leventhal, Darcie Spaulding, Mary-Jo Miller, Scott Nolan, Hilliary Hodgdon, Kevin M. Felsenstein, Zhiyong Yang, Lori Hrdlicka, Richard Chesworth, Gideon Shapiro, Winnie Lee, Melody Wen, Sarah C. Hopp
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77adba42ad74699028513476ded43b67
https://doi.org/10.1016/j.jalz.2010.08.082
https://doi.org/10.1016/j.jalz.2010.08.082
Autor:
Irena Zaninovic, Florentina Catana, Kevin M. Felsenstein, Melody Wen, Hilliary Hodgdon, Lori Hrdlicka, Faris Albayya, Scott Nolan, Kathryn Rogers, Holger Patzke, Zhiyong Yang, Michael K. Ahlijanian, Gerhard Koenig, Winnie Lee, Don Costa, Zhiming Tu, Richard Chesworth, Gideon Shapiro, Darcie Spaulding
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0153a2ab84af087c075c7cbec313b23e
https://doi.org/10.1016/j.jalz.2010.05.1795
https://doi.org/10.1016/j.jalz.2010.05.1795
Publikováno v:
American journal of nephrology. 30(6)
Cisplatin (CIS) induces nephrotoxicity partly through renal vasoconstriction and decreased glomerular filtration effects thought to involve adenosine acting on adenosine A(1) receptors (A1Rs). We studied the effect of the orally active, A1R antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54eb2334f605dbe01d3b379df2603c4d
https://pubmed.ncbi.nlm.nih.gov/19828940
https://pubmed.ncbi.nlm.nih.gov/19828940
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3126374871eecbac26f7f9e4564bc112
https://doi.org/10.1096/fasebj.23.1_supplement.754.1
https://doi.org/10.1096/fasebj.23.1_supplement.754.1