Quantifying the effects of four weeks of low-volume high-intensity sprint interval training on V̇O2max through assessment of hemodynamics

Autor: Patrick Swain, Don Keiller, Henry Chung, Viviane Merzbach, Dan Gordon, Marie Gernigon

Publikováno v: The Journal of Sports Medicine and Physical Fitness. 60

BACKGROUND Sprint interval training is a popular workout modality. Studies have eluded to a positive effect on maximal oxygen uptake, however little is known about the mechanistic basis of this adaptation. Therefore, the purpose of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ca2aa569db04ff7da6506f56a7ae7e
https://doi.org/10.23736/s0022-4707.19.09912-2

Re-annotation of 191 developmental and epileptic encephalopathy-associated genes unmasks de novo variants in

Autor: Charles A, Steward, Jolien, Roovers, Marie-Marthe, Suner, Jose M, Gonzalez, Barbara, Uszczynska-Ratajczak, Dmitri, Pervouchine, Stephen, Fitzgerald, Margarida, Viola, Hannah, Stamberger, Fadi F, Hamdan, Berten, Ceulemans, Patricia, Leroy, Caroline, Nava, Anne, Lepine, Electra, Tapanari, Don, Keiller, Stephen, Abbs, Alba, Sanchis-Juan, Detelina, Grozeva, Anthony S, Rogers, Mark, Diekhans, Roderic, Guigó, Robert, Petryszak, Berge A, Minassian, Gianpiero, Cavalleri, Dimitrios, Vitsios, Slavé, Petrovski, Jennifer, Harrow, Paul, Flicek, F, Lucy Raymond, Nicholas J, Lench, Peter De, Jonghe, Jonathan M, Mudge, Sarah, Weckhuysen, Sanjay M, Sisodiya, Adam, Frankish

Publikováno v: NPJ Genomic Medicine

The developmental and epileptic encephalopathies (DEE) are a group of rare, severe neurodevelopmental disorders, where even the most thorough sequencing studies leave 60–65% of patients without a molecular diagnosis. Here, we explore the incomplete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed837732110def8ffe866152d0c3c556
https://pubmed.ncbi.nlm.nih.gov/31814998

Re-annotation of 191 developmental and epileptic encephalopathy-associated genes unmasks de novo variants in SCN1A

Autor: Stephen Abbs, Dimitrios Vitsios, Dmitri D. Pervouchine, Paul Flicek, Hannah Stamberger, Roderic Guigó, Barbara Uszczynska-Ratajczak, F. Lucy Raymond, Margarida Viola, Jennifer Harrow, Adam Frankish, Robert Petryszak, Sarah Weckhuysen, Alba Sanchis-Juan, Caroline Nava, Electra Tapanari, José M. González, Anthony Rogers, Slavé Petrovski, Anne Fabienne Lepine, Patricia Leroy, Detelina Grozeva, Marie Marthe Suner, Mark Diekhans, Gianpiero L. Cavalleri, Don Keiller, Berten Ceulemans, Nicholas Lench, Jonathan M. Mudge, Jolien Roovers, Stephen Fitzgerald, Berge A. Minassian, Charles A. Steward, Peter De Jonghe, Sanjay M. Sisodiya, Fadi F. Hamdan

Publikováno v: Npj genomic medicine
npj Genomic Medicine, Vol 4, Iss 1, Pp 1-11 (2019)
Recercat. Dipósit de la Recerca de Catalunya
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The developmental and epileptic encephalopathies (DEE) are a group of rare, severe neurodevelopmental disorders, where even the most thorough sequencing studies leave 60–65% of patients without a molecular diagnosis. Here, we explore the incomplete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719086b39714e946b1cc05f5c5d1f337
https://hdl.handle.net/10067/1650780151162165141

Prior Knowledge of Trial Number Influences the Incidence of Plateau at VO2max

Autor: Dan Gordon, Oliver Caddy, Viviane Merzbach, Marie Gernigon, James Baker, Adrian Scruton, Don Keiller, Richard Barnes

Publikováno v: Journal of Sports Science and Medicine, Vol 14, Iss 1, Pp 47-53 (2015)

The purpose of this study was to assess the VO2max plateau response at VO2max during a series of pre-determined trials. METHODS: Ten male well-trained athletes (age, 23.0 ± 3.2; height, 183.3 ± 5.5 cm; mass 77.5 ± 11.1 Kg; VO2max 66.5 ± 5.0 ml.kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::5036ddbc43b561400f7a48164737d763
http://www.jssm.org/abstresearcha.php?id=jssm-14-47.xml

Influence of blood donation on the incidence of plateau at $$ \dot{V}{\text{O}} $$ V ˙ O 2max

Autor: James Baker, Oliver Caddy, Dan Gordon, Viviane Merzbach, Andrew Porter, Madeleine Wood, Richard Barnes, Vignesh Vetrivel, Don Keiller, Marie Gernigon

Publikováno v: European Journal of Applied Physiology. 114:21-27

The purpose of this study was to examine the effects of reductions in blood volume and associated oxygen-carrying capacity on the incidence of plateau at $$\dot{V}{\text{O}}$$ 2max. Fifteen well-trained athletes (age 23.3 ± 4.5; mass 77.4 ± 13.1 kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4403f68da5611c782ef71c15beff0491
https://doi.org/10.1007/s00421-013-2743-3