Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila

Autor: Matute, Juan D., Duan, Jinzhi, Flak, Magdalena B., Griebel, Paul, Tascon-Arcila, Jose A., Doms, Shauni, Hanley, Thomas, Antanaviciute, Agne, Gundrum, Jennifer, Mark Welch, Jessica L., Sit, Brandon, Abtahi, Shabnam, Fuhler, Gwenny M., Grootjans, Joep, Tran, Florian, Stengel, Stephanie T., White, James R., Krupka, Niklas, Haller, Dirk, Clare, Simon, Lawley, Trevor D., Kaser, Arthur, Simmons, Alison, Glickman, Jonathan N., Bry, Lynn, Rosenstiel, Philip, Borisy, Gary, Waldor, Matthew K., Baines, John F., Turner, Jerrold R., Blumberg, Richard S.

Publikováno v: The Journal of experimental medicine, 220(1):e20211938. Rockefeller University Press

Intelectin-1 (ITLN1) is a lectin secreted by intestinal epithelial cells (IECs) and upregulated in human ulcerative colitis (UC). We investigated how ITLN1 production is regulated in IECs and the biological effects of ITLN1 at the host-microbiota int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2bd14d98fcafe2be88189e1665e2d8c4
https://www.repository.cam.ac.uk/handle/1810/344772

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Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosaassociated gut microbiome in hybrid mice.

Autor: Doms, Shauni, Fokt, Hanna, Rühlemann, Malte Christoph, Chung, Cecilia J., Kuenstner, Axel, Ibrahim, Saleh M., Franke, Andre, Turner, Leslie M., Baines, John F.

Publikováno v: eLife; 7/19/2022, p1-30, 30p

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Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.

Autor: Matute JD; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Duan J; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Flak MB; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Griebel P; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Tascon-Arcila JA; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Doms S; Guest Group Evolutionary Medicine, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Institute of Experimental Medicine, Kiel University, Kiel, Germany., Hanley T; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Antanaviciute A; Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK., Gundrum J; The Forsyth Institute, Cambridge, MA., Mark Welch JL; Marine Biological Laboratory, Woods Hole, MA., Sit B; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA.; Department of Microbiology, Harvard Medical School, Boston, MA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA.; Howard Hughes Medical Institute, Boston, MA., Abtahi S; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Fuhler GM; Department of Gastroenterology & Hepatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands., Grootjans J; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology and Metabolism & Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, Netherlands., Tran F; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Stengel ST; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., White JR; Resphera Biosciences, Baltimore, MD., Krupka N; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Haller D; Nutrition and Immunology, Technische Universität München, Freising, Germany., Clare S; Wellcome Trust Sanger Institute, Hinxton, UK., Lawley TD; Wellcome Trust Sanger Institute, Hinxton, UK., Kaser A; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, and Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK., Simmons A; Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK., Glickman JN; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Bry L; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Rosenstiel P; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany., Borisy G; The Forsyth Institute, Cambridge, MA., Waldor MK; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA.; Department of Microbiology, Harvard Medical School, Boston, MA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA.; Howard Hughes Medical Institute, Boston, MA., Baines JF; Guest Group Evolutionary Medicine, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Institute of Experimental Medicine, Kiel University, Kiel, Germany., Turner JR; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Blumberg RS; Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Jan 02; Vol. 220 (1). Date of Electronic Publication: 2022 Nov 22.