Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids.

Autor: Jørgensen JS; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark., Mood EH; Center for Peptide-Based Antibiotics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Panum Building, 3C Blegdamsvej, DK-2200 Copenhagen N, Denmark., Knap ASH; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark., Nielsen SE; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark., Nielsen PE; Center for Peptide-Based Antibiotics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Panum Building, 3C Blegdamsvej, DK-2200 Copenhagen N, Denmark., Żabicka D; Department of Epidemiology and Clinical Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland., Matias C; Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark., Domraceva I; Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia., Björkling F; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark., Franzyk H; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1370-1383. Date of Electronic Publication: 2024 Jan 03.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties.

Autor: Frederiksen N; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Louka S; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Mudaliar C; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Domraceva I; Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia., Kreicberga A; Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia., Pugovics O; Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia., Żabicka D; Department of Epidemiology and Clinical Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland., Tomczak M; Department of Epidemiology and Clinical Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland., Wygoda W; Department of Epidemiology and Clinical Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland., Björkling F; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark., Franzyk H; Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 30; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 30.

Enhancing Antimicrobial Peptide Activity through Modifications of Charge, Hydrophobicity, and Structure.

Autor: Gagat, Przemysław¹ (AUTHOR) michal.ostrowka2@uwr.edu.pl, Ostrówka, Michał¹ (AUTHOR) pawel.mackiewicz@uwr.edu.pl, Duda-Madej, Anna² (AUTHOR) anna.duda-madej@umw.edu.pl, Mackiewicz, Paweł¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10821. 17p.

Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development.

Autor: Appetecchia, Federico¹ (AUTHOR), Fabbrizi, Emanuele¹ (AUTHOR), Fiorentino, Francesco¹ (AUTHOR), Consalvi, Sara¹ (AUTHOR) federico.appetecchia@uniroma1.it, Biava, Mariangela¹ (AUTHOR), Poce, Giovanna¹ (AUTHOR) giovanna.poce@uniroma1.it, Rotili, Dante¹ (AUTHOR) giovanna.poce@uniroma1.it

Publikováno v: Pharmaceuticals (14248247). Jul2024, Vol. 17 Issue 7, p962. 39p.